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Article Title |
Author(s) |
Type (Status) |
Available Online |
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Ex Vivo and In Vivo Evaluation of the Norepinephrine Transporter Ligand [11C]MRB for Brown Adipose Tissue Imaging
DOI: 10.1016/j.nucmedbio.2012.04.005
Abstract: Introduction: It has been suggested that brown adipose tissue (BAT) in humans may play a role in energy balance and obesity. We conducted ex vivo and in vivo evaluation using [11C]MRB, a hig...
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Shu-fei Lin,
Xiaoning Fan,
Catherine Weikart Yeckel,
David Weinzimmer,
Tim Mulnix,
Jean-Dominique Gallezot,
Richard E. Carson,
Robert S. Sherwin,
Yu-Shin Ding
et al.
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Full-length article
(In Press Corrected Proof)
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18 May 2012 |
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[18F]desmethoxyfallypride as a novel PET radiotracer for quantitative in vivo dopamine D2/D3 receptor imaging in rat models of neurodegenerative diseases
DOI: 10.1016/j.nucmedbio.2012.04.003
Abstract: Introduction: [18F]desmethoxyfallypride ([18F]DMFP) is a promising tracer for longitudinal assessment of striatal dopamine D2/D3-receptor (D2R) availability by positron emission tomography (...
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Máté D. Döbrössy,
Friederike Braun,
Stefanie Klein,
Joanna Garcia,
Karl-Josef Langen,
Wolfgang A. Weber,
Guido Nikkhah,
Philipp T. Meyer
et al.
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Full-length article
(In Press Corrected Proof)
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17 May 2012 |
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Automated GMP Synthesis of [18F]ICMT-11 for In Vivo Imaging of Caspase-3 Activity
DOI: 10.1016/j.nucmedbio.2012.03.004
Abstract: Introduction: Isatin-5-sulfonamide ([18F]ICMT-11) is a sub-nanomolar inhibitor of caspase-3 previously evaluated as an apoptosis imaging agent. Herein, an alternative radiosynthesis of [18F]...
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Robin Fortt,
Graham Smith,
Ramla O. Awais,
Sajinder K. Luthra,
Eric O. Aboagye
et al.
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Full-length article
(In Press Corrected Proof)
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10 May 2012 |
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Synthesis of [18F]-labeled (2-(2-fluoroethoxy)ethyl)tris(4-methoxyphenyl)phosphonium cation as a potential agent for positron emission tomography myocardial imaging
DOI: 10.1016/j.nucmedbio.2012.03.008
Abstract: Introduction: Established radiotracers for positron emission tomography (PET) myocardial perfusion study are commonly labeled with short-lived radio-isotopes that limit their widespread clin...
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Dong-Yeon Kim,
Hee-Jung Kim,
Kook-Hyun Yu,
Jung-Joon Min
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Full-length article
(In Press Corrected Proof)
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10 May 2012 |
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The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH)
DOI: 10.1016/j.nucmedbio.2012.03.011
Abstract: Introduction: Fatty acid amide hydrolase (FAAH) is responsible for the enzymatic degradation of the fatty acid amide family of signaling lipids, including the endogenous cannabinoid (endocan...
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Marc B. Skaddan,
Lei Zhang,
Douglas S. Johnson,
Aijun Zhu,
Kenneth R. Zasadny,
Richard V. Coelho,
Kyle Kuszpit,
Gwen Currier,
Kuo-Hsien Fan,
Elizabeth M. Beck,
Laigao Chen,
Susan E. Drozda,
Gayatri Balan,
Micah Niphakis,
Benjamin F. Cravatt,
Kay Ahn,
Thomas Bocan,
Anabella Villalobos
et al.
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Full-length article
(In Press Corrected Proof)
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09 May 2012 |
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18F-fluorodeoxyglucose positron emission tomography in management of pancreatic cystic tumors
DOI: 10.1016/j.nucmedbio.2012.03.005
Abstract: Objectives: To evaluate the effectiveness of PET in differentiating malignant from benign pancreatic cystic tumors. Methods: Between 2009 and 2010, all patients with pancreatic cystic tumors...
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Yaojun Zhang,
Adam E. Frampton,
Jack L. Martin,
Charis Kyriakides,
Jan Jin Bong,
Nagy A. Habib,
Panagiotis Vlavianos,
Long R. Jiao
et al.
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Full-length article
(In Press Corrected Proof)
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07 May 2012 |
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The effects of 5-fluoruracil treatment on 3′-fluoro-3′-deoxythymidine (FLT) transport and metabolism in proliferating and non-proliferating cultures of human tumor cells
DOI: 10.1016/j.nucmedbio.2012.03.009
Abstract: 3′-Fluoro-3′-deoxythymidine (FLT) positron emission tomography (PET) has been proposed for imaging thymidylate synthase (TS) inhibition. Agents that target TS and shut down de novo synthesis...
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David A. Plotnik,
Lena J. McLaughlin,
Kenneth A. Krohn,
Jeffrey L. Schwartz
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Full-length article
(In Press Corrected Proof)
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07 May 2012 |
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Acute treatment with fluvoxamine elevates rat brain serotonin synthesis in some terminal regions: An autoradiographic study
DOI: 10.1016/j.nucmedbio.2012.04.001
Abstract: Introduction: A considerable body of evidence indicates the involvement of the neurotransmitter serotonin (5-HT) in the pathogenesis and treatment of depression. Methods: The acute effect of...
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Dorotea Muck-Seler,
Nela Pivac,
Mirko Diksic
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Full-length article
(In Press Corrected Proof)
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07 May 2012 |
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Synthesis and evaluation of 18F labeled alanine derivatives as potential tumor imaging agents
DOI: 10.1016/j.nucmedbio.2012.03.007
Abstract: Introduction: This paper reports the synthesis and labeling of 18F alanine derivatives. We also investigate their biological characteristics as potential tumor imaging agents mediated by ala...
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Limin Wang,
Zhihao Zha,
Wenchao Qu,
Hongwen Qiao,
Brian P. Lieberman,
Karl Plössl,
Hank F. Kung
et al.
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Full-length article
(In Press Corrected Proof)
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30 April 2012 |
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Synthesis, in vitro and in vivo characterization of novel 99mTc-‘4+1’-labeled 5-nitroimidazole derivatives as potential agents for imaging hypoxia
DOI: 10.1016/j.nucmedbio.2011.12.012
Abstract: The evaluation of oxygenation status of solid tumors is an important field of radiopharmaceutical research. With the aim to develop new potential 99mTc-radiopharmaceuticals for imaging hypox...
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Javier Giglio,
Soledad Fernández,
Hans-Jürgen Pietzsch,
Sylvia Dematteis,
María Moreno,
José P. Pacheco,
Hugo Cerecetto,
Ana Rey
et al.
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Full-length article
(In Press Corrected Proof)
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25 April 2012 |
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Understanding the in vivo uptake kinetics of a phosphatidylethanolamine-binding agent 99mTc-Duramycin
DOI: 10.1016/j.nucmedbio.2012.02.004
Abstract: Introduction: 99mTc-Duramycin is a peptide-based molecular probe that binds specifically to phosphatidylethanolamine (PE). The goal was to characterize the kinetics of molecular interactions...
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Said Audi,
Zhixin Li,
Joseph Capacete,
Yu Liu,
Wei Fang,
Laura G. Shu,
Ming Zhao
et al.
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Full-length article
(In Press Corrected Proof)
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25 April 2012 |
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Preliminary studies of 99mTc-memantine derivatives for NMDA receptor imaging
DOI: 10.1016/j.nucmedbio.2012.02.008
Abstract: Introduction: Novel technetium-labeled ligands, 99mTc-NCAM and 99mTc-NHAM were developed from the N-methyl-d-aspartate (NMDA) receptor agonist memantine as a lead compound by coupling with N...
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Xingqin Zhou,
Jiankang Zhang,
Chenglong Yan,
Guoxian Cao,
Rongjun Zhang,
Gangming Cai,
Mengjun Jiang,
Songpei Wang
et al.
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Full-length article
(In Press Corrected Proof)
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19 April 2012 |
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A method to predict response of cell populations to cocktails of chemotherapeutics and radiopharmaceuticals: Validation with daunomycin, doxorubicin, and the alpha particle emitter 210Po
DOI: 10.1016/j.nucmedbio.2012.01.011
Abstract: There is considerable interest in the use of α-emitting radionuclides in radioimmunotherapy. However, the high toxicity of α-emitting radionuclides often does not permit administration of hi...
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John M. Akudugu,
Roger W. Howell
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Full-length article
(In Press Corrected Proof)
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16 April 2012 |
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Microwave-assisted one-pot radiosynthesis of 2′-deoxy-2′-[18F]fluoro-5-methyl-1-β-d-arabinofuranosyluracil ([18F]-FMAU)
DOI: 10.1016/j.nucmedbio.2012.03.003
Abstract: Objectives: [18F]-FMAU is a PET tracer being evaluated for imaging cell proliferation. Current multi-step procedures of [18F]-FMAU synthesis are time-consuming, resulting in low radiochemica...
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Kai Chen,
Zibo Li,
Peter S. Conti
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Full-length article
(In Press Corrected Proof)
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13 April 2012 |
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In vitro characterization of [18F]-florbetaben, an Aβ imaging radiotracer
DOI: 10.1016/j.nucmedbio.2012.03.001
Abstract: Purpose: Amyloid-β (Aβ) plaques are a major pathological hallmark of Alzheimer's disease (AD). The noninvasive detection of Aβ plaques may increase the accuracy of clinical diagnosis as well...
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Michelle T. Fodero-Tavoletti,
Damian Brockschnieder,
Victor L. Villemagne,
Lucas Martin,
Andrea R. Connor,
Andrea Thiele,
Mathias Berndt,
Catriona A. McLean,
Sabine Krause,
Christopher C. Rowe,
Colin L. Masters,
Ludger Dinkelborg,
Thomas Dyrks,
Roberto Cappai
et al.
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Full-length article
(In Press Corrected Proof)
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13 April 2012 |
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Re-evaluation of in vivo selectivity of [11C]SA4503 to σ1 receptors in the brain: Contributions of emopamil binding protein
DOI: 10.1016/j.nucmedbio.2012.03.002
Abstract: Introduction: Carbon-11-labeled 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine ([11C]SA4503) was shown to be a promising PET ligand for mapping σ1 receptors, and was applied t...
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Jun Toyohara,
Muneyuki Sakata,
Kiichi Ishiwata
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Full-length article
(In Press Corrected Proof)
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12 April 2012 |
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A comparison of in vitro methods for determining the membrane receptor expression in cell lines
DOI: 10.1016/j.nucmedbio.2012.02.007
Abstract: Introduction: Determining the number of expressed receptors per cell (NRPC) in cell lines is an important prerequisite for many experimental procedures in biomedical research. This paper foc...
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Zbynek Novy,
Pavel Barta,
Jana Mandikova,
Milan Laznicek,
Frantisek Trejtnar
et al.
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Full-length article
(In Press Corrected Proof)
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12 April 2012 |
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Comparison of 3′-deoxy-3′-[18F]fluorothymidine PET and O-(2-[18F]fluoroethyl)-L-tyrosine PET in patients with newly diagnosed glioma
DOI: 10.1016/j.nucmedbio.2012.02.009
Abstract: Purpose: The purpose of this prospective study was to clarify the value of FLT PET and FET PET for the noninvasive grading and prognosis of newly diagnosed gliomas. Materials and methods: Tw...
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Su Young Jeong,
Sang Moo Lim
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Full-length article
(In Press Corrected Proof)
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09 April 2012 |
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Preliminary studies on 177Lu-labeled sodium pyrophosphate (177Lu-PYP) as a potential bone-seeking radiopharmaceutical for bone pain palliation
DOI: 10.1016/j.nucmedbio.2012.02.001
Abstract: Objective: 99mTc-Sn-PYP (Technetium-99m labeled tin pyrophosphate) has been widely used as a radiopharmaceutical for bone scanning as well as in nuclear cardiology. It is also found in the b...
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Imtiaz Ahmed Abbasi
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Full-length article
(In Press Corrected Proof)
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30 March 2012 |
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[123I]Epidepride neuroimaging of dopamine D2/D3 receptor in chronic MK-801-induced rat schizophrenia model
DOI: 10.1016/j.nucmedbio.2012.01.005
Abstract: Purpose: [123I]Epidepride is a radio-tracer with very high affinity for dopamine D2/D3 receptors in brain. The importance of alteration in dopamine D2/D3 receptor binding condition has been ...
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Yuan-Ruei Huang,
Jun-Ming Shih,
Kang-Wei Chang,
Chieh Huang,
Yu-Lung Wu,
Chia-Chieh Chen
et al.
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Full-length article
(In Press Corrected Proof)
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30 March 2012 |
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A preclinical investigation of the saturation and dosimetry of 153Sm-DOTMP as a bone-seeking radiopharmaceutical
DOI: 10.1016/j.nucmedbio.2011.12.015
Abstract: Introduction: The therapeutic potential of the bone-seeking radiopharmaceutical 153Sm-labeled 1,4,7,10-tetraazacyclododecanetetramethylenephosphonic acid (153Sm-DOTMP) was assessed by measur...
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Jaime Simón,
R. Keith Frank,
Druce K. Crump,
William D. Erwin,
Naoto T. Ueno,
Richard E. Wendt
et al.
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Full-length article
(In Press Corrected Proof)
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29 March 2012 |
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Nephrotoxicity profiles and threshold dose values for [177Lu]-DOTATATE in nude mice
DOI: 10.1016/j.nucmedbio.2012.02.003
Abstract: Introduction: In peptide receptor radionuclide therapy for neuroendocrine tumors the main dose-limiting tissue is found in the kidneys because of tubular reabsorption and retention of radioa...
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Johanna Svensson,
Johan Mölne,
Eva Forssell-Aronsson,
Mark Konijnenberg,
Peter Bernhardt
et al.
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Full-length article
(In Press Corrected Proof)
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27 March 2012 |
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Novel synthesis and preclinical evaluation of folic acid derivatives labeled with 18F-[FDG] for PET imaging of folate receptor-positive tumors
DOI: 10.1016/j.nucmedbio.2012.02.005
Abstract: There is a need to develop more potent radiofluorinated folic acid conjugates for a better visualization of folate receptors that overexpress on many human cancers. Due to the clinical impor...
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I. Al Jammaz,
B. Al-Otaibi,
S. Amer,
N. Al-Hokbany,
S. Okarvi
et al.
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Full-length article
(In Press Corrected Proof)
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27 March 2012 |
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In vivo evaluation of [18F]FEAnGA-Me: a PET tracer for imaging β-glucuronidase (β-GUS) activity in a tumor/inflammation rodent model
DOI: 10.1016/j.nucmedbio.2012.02.002
Abstract: Introduction: The PET tracer, 1-O-(4-(2-fluoroethyl-carbamoyloxymethyl)-2-nitrophenyl)-O-β-d-glucopyronuronate ([18F]FEAnGA), was recently developed for PET imaging of extracellular β-glucur...
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Inês F. Antunes,
Hidde J. Haisma,
Philip H. Elsinga,
Jurgen W.A. Sijbesma,
Aren van Waarde,
Antoon T.M. Willemsen,
Rudi A. Dierckx,
Erik F.J. de Vries
et al.
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Full-length article
(In Press Corrected Proof)
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27 March 2012 |
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68Ga-NODAGA-RGD is a suitable substitute for 18F-Galacto-RGD and can be produced with high specific activity in a cGMP/GRP compliant automated process
DOI: 10.1016/j.nucmedbio.2012.02.006
Abstract: Introduction: 18F-Galacto-cyclo(RGDfK) is a well investigated tracer for imaging of ανβ3 expression in vivo, but suffers from the drawback of a time consuming multistep synthesis that can ha...
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Karolin Pohle,
Johannes Notni,
Johanna Bussemer,
Horst Kessler,
Markus Schwaiger,
Ambros J. Beer
et al.
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Full-length article
(In Press Corrected Proof)
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23 March 2012 |
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Tryptophan metabolism in breast cancers: molecular imaging and immunohistochemistry studies
DOI: 10.1016/j.nucmedbio.2012.01.010
Abstract: Introduction: Tryptophan oxidation via the kynurenine pathway is an important mechanism of tumoral immunoresistance. Increased tryptophan metabolism via the serotonin pathway has been linked...
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Csaba Juhász,
Zeina Nahleh,
Ian Zitron,
Diane C. Chugani,
Majid Z. Janabi,
Sudeshna Bandyopadhyay,
Rouba Ali-Fehmi,
Thomas J. Mangner,
Pulak K. Chakraborty,
Sandeep Mittal,
Otto Muzik
et al.
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Full-length article
(In Press Corrected Proof)
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23 March 2012 |
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Whole-body distribution and radiation dosimetry of [11C]telmisartan as a biomarker for hepatic organic anion transporting polypeptide (OATP) 1B3
DOI: 10.1016/j.nucmedbio.2012.01.008
Abstract: Introduction: Telmisartan, a nonpeptide angiotensin II AT1 receptor antagonist used as an antihypertensive drug, is specifically taken up by the liver through the OATP1B3. PET imaging with [...
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Keiji Shimizu,
Tadayuki Takashima,
Tomohiko Yamane,
Masahiro Sasaki,
Hiromitsu Kageyama,
Yoshinobu Hashizume,
Kazuya Maeda,
Yuichi Sugiyama,
Yasuyoshi Watanabe,
Michio Senda
et al.
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Full-length article
(In Press Corrected Proof)
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15 March 2012 |
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In vivo and in vitro evaluation of Cy5.5 conjugated epidermal growth factor receptor binding peptide
DOI: 10.1016/j.nucmedbio.2012.01.001
Abstract: The epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor and plays an important role in carcinogenesis. In this study, the epidermal growth factor receptor binding peptide (...
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Min-Hee Jeong,
Kisu Kim,
Eun-Mi Kim,
Su-Jin Cheong,
Chang-Moon Lee,
Hwan-Jeong Jeong,
Dong Wook Kim,
Seok Tae Lim,
Myung-Hee Sohn,
Junho Chung
et al.
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Full-length article
(In Press Corrected Proof)
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15 March 2012 |
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Evaluation of the angiogenesis inhibitor KR-31831 in SKOV-3 tumor-bearing mice using 64Cu-DOTA-VEGF121 and microPET
DOI: 10.1016/j.nucmedbio.2012.01.007
Abstract: KR-31831 ((2R,3R,4S)-6-amino-4-[N-(4-chloropheyl)-N-(1H-imidazol-2ylmethyl)amino]-3-hydroxyl-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran), an angiogenesis inhibitor, was evaluated...
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Iljung Lee,
Kwang Yup Yoon,
Choong Mo Kang,
Xin Lin,
Xiaoyuan Chen,
Jung Young Kim,
Sung-Min Kim,
Eun Kyoung Ryu,
Yearn Seong Choe
et al.
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Full-length article
(In Press Corrected Proof)
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14 March 2012 |
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Repeatability of FDG quantification in tumor imaging: averaged SUVs are superior to SUVmax
DOI: 10.1016/j.nucmedbio.2011.11.002
Abstract: Purpose: Reliable 18F-fluorodeoxyglucose (FDG) uptake quantification is crucial for cancer treatment monitoring. While interobserver variability has been found to be lower for a maximum stan...
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Irene A. Burger,
Dominic M. Huser,
Cyrill Burger,
Gustav K. von Schulthess,
Alfred Buck
et al.
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Full-length article
(In Press Corrected Proof)
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02 March 2012 |
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Preparation and evaluation of bombesin peptide derivatives as potential tumor imaging agents: effects of structure and composition of amino acid sequence on in vitro and in vivo characteristics
DOI: 10.1016/j.nucmedbio.2012.01.002
Abstract: Objectives: Among the many clinically relevant peptide receptor systems, bombesin (BN) receptors have attracted enormous attraction due to their overexpression in various frequently occurrin...
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Subhani M. Okarvi,
Ibrahim A. Jammaz
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Full-length article
(In Press Corrected Proof)
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02 March 2012 |
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11C-5-hydroxytryptophan positron emission tomography after radiofrequency ablation of neuroendocrine tumor liver metastases
DOI: 10.1016/j.nucmedbio.2011.12.013
Abstract: Aim: The aim was to assess the feasibility of 11C-5-hydroxy-tryptophan positron emission tomography (11C-5-HTP-PET) in the follow-up after radiofrequency ablation (RFA) of liver metastases f...
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Olov Norlén,
Anders Nilsson,
Johan Krause,
Peter Stålberg,
Per Hellman,
Anders Sundin
et al.
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Full-length article
(In Press Corrected Proof)
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02 March 2012 |
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High molecular mass radioimmunoconjugates are promising for intraperitoneal α-emitter immunotherapy due to prolonged retention in the peritoneum
DOI: 10.1016/j.nucmedbio.2011.12.005
Abstract: Introduction: Therapeutic efficacy of intraperitoneal radioimmunotherapy is dependent on the time of retention of the radioimmunoconjugates within the peritoneal cavity. Therefore, the aim o...
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Christian Rauch,
Christof Seidl,
Martin Schlapschy,
Arne Skerra,
Alfred Morgenstern,
Frank Bruchertseifer,
Reingard Senekowitsch-Schmidtke
et al.
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Full-length article
(In Press Corrected Proof)
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02 March 2012 |
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RGD conjugates of the H2dedpa scaffold: synthesis, labeling and imaging with 68Ga
DOI: 10.1016/j.nucmedbio.2012.01.003
Abstract: Introduction: The rekindled interest in the 68Ga generator as an attractive positron emission tomography generator system has led us and others to investigate novel chelate systems for 68Ga....
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Eszter Boros,
Cara L. Ferreira,
Donald T.T. Yapp,
Rajanvir K. Gill,
Eric W. Price,
Michael J. Adam,
Chris Orvig
et al.
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Full-length article
(In Press Corrected Proof)
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02 March 2012 |
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Radiolabelling and evaluation of novel haloethylsulfoxides as PET imaging agents for tumor hypoxia
DOI: 10.1016/j.nucmedbio.2012.01.004
Abstract: The significance of imaging hypoxia with the PET ligand [18F]FMISO has been demonstrated in a variety of cancers. However, the slow kinetics of [18F]FMISO require a 2-h delay between tracer ...
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Evelyn Laurens,
Shinn Dee Yeoh,
Angela Rigopoulos,
Diana Cao,
Glenn A. Cartwright,
Graeme J. O'Keefe,
Henri J. Tochon-Danguy,
Jonathan M. White,
Andrew M. Scott,
Uwe Ackermann
et al.
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Full-length article
(In Press Corrected Proof)
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16 February 2012 |
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Robust labeling and comparative preclinical characterization of DOTA-TOC and DOTA-TATE
DOI: 10.1016/j.nucmedbio.2011.12.010
Abstract: Objectives: Various radionuclide-labeled somatostatin analogues are used currently for diagnosis and therapy of neuroendocrine tumors. In particular, [68Ga]Ga-DOTA-TOC is commonly used for d...
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Irina Velikyan,
Hui Xu,
Manoj Nair,
Håkan Hall
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Full-length article
(In Press Corrected Proof)
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16 February 2012 |
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Synthesis of ApoSense compound [18F]2-(5-(dimethylamino)naphthalene-1-sulfonamido)-2-(fluoromethyl)butanoic acid ([18F]NST732) by nucleophilic ring opening of an aziridine precursor
DOI: 10.1016/j.nucmedbio.2011.12.008
Abstract: Introduction: The small molecule 2-(5-(dimethylamino)naphthalene-1-sulfonamido)-2-(fluoromethyl)butanoic acid (NST732) is a member of the ApoSense family of compounds, capable of selective t...
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Falguni Basuli,
Haitao Wu,
Zhen-Dan Shi,
Bao Teng,
Changhui Li,
Agnieszka Sulima,
Aaron Bate,
Philip Young,
Mathew McMillan,
Gary L. Griffiths
et al.
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Full-length article
(In Press Corrected Proof)
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16 February 2012 |
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A multimodality reporter gene for monitoring transplanted stem cells
DOI: 10.1016/j.nucmedbio.2011.12.014
Abstract: Introduction: The aim of this study is to explore the feasibility of a triple-fused reporter gene, termed TGF [herpes simplex virus type 1 thymidine kinase (HSV1-tk), enhanced green fluoresc...
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Zhijun Pei,
Xiaoli Lan,
Zhen Cheng,
Chunxia Qin,
Peng Wang,
Yong He,
Tzu-Chen Yen,
Yueli Tian,
Fabian Pius Mghanga,
Yongxue Zhang
et al.
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Full-length article
(In Press Corrected Proof)
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16 February 2012 |
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Use of gated 13N-NH3 micro-PET to examine left ventricular function in rats
DOI: 10.1016/j.nucmedbio.2011.12.009
Abstract: Introduction: Myocardial perfusion gating techniques offer the possibility of measurement of left ventricular end-systolic (ESV) and end-diastolic volume (EDV) and left ventricular ejection ...
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Mariusz K. Szymanski,
Silvana Kruizinga,
René A. Tio,
Antoon T.M. Willemsen,
Michael A. Schäfers,
Lars Stegger,
Rudi A. Dierckx,
Hans L. Hillege,
Riemer H.J.A. Slart
et al.
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Full-length article
(In Press Corrected Proof)
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16 February 2012 |
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Pd2(dba)3/P(MeNCH2CH2)3N·HCl-mediated Stille cross-coupling of [1-11C]acetyl chloride with aryl and heteroaryl stannanes
DOI: 10.1016/j.nucmedbio.2011.12.011
Abstract: Introduction: Developments in the Stille cross-coupling of [1-11C]acetyl chloride with tributylphenylstannane mediated by the Pd2(dba)3/P(MeNCH2CH2)3N·HClsystem are reported. Methods: The re...
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Takuya Arai
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Full-length article
(In Press Corrected Proof)
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16 February 2012 |
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Synthesis and evaluation of nucleoside radiotracers for imaging proliferation
DOI: 10.1016/j.nucmedbio.2011.12.002
Abstract: Introduction: Uncontrolled proliferation is a fundamental characteristic of cancer, and consequently, imaging of tumor proliferative status finds interest clinically both as a diagnostic too...
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Graham Smith,
Roberta Sala,
Laurence Carroll,
Kevin Behan,
Matthias Glaser,
Edward Robins,
Quang-Dé Nguyen,
Eric O. Aboagye
et al.
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Full-length article
(In Press Corrected Proof)
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10 February 2012 |
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Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody
DOI: 10.1016/j.nucmedbio.2011.12.001
Abstract: Introduction: We previously demonstrated MORF/cMORF pretargeting of human islets and betalox 5 cells (a human beta cell line) transplanted subcutaneously in mice with the anti-human islet an...
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Guozheng Liu,
Shuping Dou,
Ali Akalin,
Mary Rusckowski,
Philip R. Streeter,
Leonard D. Shultz,
Dale L. Greiner
et al.
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Full-length article
(In Press Corrected Proof)
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10 February 2012 |
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Radiolabeled Zn-DPA as a potential infection imaging agent
DOI: 10.1016/j.nucmedbio.2011.12.006
Abstract: Introduction: A zinc-dipicolylamine analog (Zn-DPA) conjugated with a fluorophore (PSVue®794) has been shown to image bacterial infections in mice. However, radiolabeled Zn-DPA has not previ...
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Xinrong Liu,
Dengfeng Cheng,
Brian D. Gray,
Yuzhen Wang,
Ali Akalin,
Mary Rusckowski,
Koon Y. Pak,
Donald J. Hnatowich
et al.
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Full-length article
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10 February 2012 |
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Radiation dosimetry of the translocator protein ligands [18F]PBR111 and [18F]PBR102
DOI: 10.1016/j.nucmedbio.2011.11.003
Abstract: Introduction: The translocator protein (TSPO) ligands [18F]PBR111 and [18F]PBR102 show promise for imaging neuroinflammation. Our aim was to estimate the radiation dose to humans from primat...
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Jordan D. Verschuer,
Jocelyn Towson,
Stefan Eberl,
Andrew Katsifis,
David Henderson,
Peter Lam,
Lingfeng Wen,
Christian Loc'h,
Filomena Mattner,
Sally Thomson,
Armin Mohamed,
Michael J. Fulham
et al.
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Full-length article
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02 February 2012 |
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A fast chemoenzymatic synthesis of [11C]-N5,N10-methylenetetrahydrofolate as a potential PET tracer for proliferating cells
DOI: 10.1016/j.nucmedbio.2011.12.003
Abstract: Introduction: Thymidylate synthase and folate receptors are well-developed targets of cancer therapy. Discovery of a simple and fast method for the conversion of 11CH3Ito[11C]-formaldehyde (...
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Muhammad Saeed,
Timothy J. Tewson,
Colbin E. Erdahl,
Amnon Kohen
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Full-length article
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02 February 2012 |
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Evaluation of 68Ga-labeled tracers for PET imaging of myocardial perfusion in pigs
DOI: 10.1016/j.nucmedbio.2011.11.007
Abstract: Purpose: We evaluated four potential gallium-68 (68Ga)-labeled tracers for positron emission tomography (PET) imaging of myocardial perfusion in comparison with oxygen-15-labeled water ([15O...
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Miikka Tarkia,
Antti Saraste,
Tiina Saanijoki,
Vesa Oikonen,
Tommi Vähäsilta,
Marjatta Strandberg,
Christoffer Stark,
Tuula Tolvanen,
Mika Teräs,
Timo Savunen,
Mark A. Green,
Juhani Knuuti,
Anne Roivainen
et al.
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20 January 2012 |
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Quantification of regional cerebral blood flow in rats using an arteriovenous shunt and micro-PET
DOI: 10.1016/j.nucmedbio.2011.11.004
Abstract: Introduction: Measurement of regional cerebral blood flow (rCBF) in rodents can provide knowledge of pathophysiology of the cerebral circulation, but generally requires blood sampling for an...
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Takayuki Ose,
Hiroshi Watabe,
Takuya Hayashi,
Nobuyuki Kudomi,
Masaaki Hikake,
Hajime Fukuda,
Noboru Teramoto,
Yasuyoshi Watanabe,
Hirotaka Onoe,
Hidehiro Iida
et al.
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20 January 2012 |
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A historical perspective on the specific activity of radiopharmaceuticals: what have we learned in the 35 years of the ISRC?
DOI: 10.1016/j.nucmedbio.2011.11.005
Abstract: Specific activity (SA), defined as the amount of radioactivity per unit mass of a compound, is arguably one of the most important parameters in radiopharmaceutical development, particularly ...
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Suzanne E. Lapi,
Michael J. Welch
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Review article
(In Press Corrected Proof)
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20 January 2012 |
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In vitro and in vivo evaluation of a 64Cu-labeled NOTA-Bn-SCN-Aoc-bombesin analogue in gastrin-releasing peptide receptor expressing prostate cancer
DOI: 10.1016/j.nucmedbio.2011.12.004
Abstract: Introduction: Bombesin (BN) is an amphibian peptide that binds to the gastrin-releasing peptide receptor (GRPR). It has been demonstrated that BN analogues can be radiolabeled for potential ...
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Jeffrey M. Craft,
Ravindra A. De Silva,
Kimberly A. Lears,
Rebecca Andrews,
Kexian Liang,
Samuel Achilefu,
Buck E. Rogers
et al.
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Full-length article
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20 January 2012 |
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Varenicline increases in vivo striatal dopamine D2/3 receptor binding: an ultra-high-resolution pinhole [123I]IBZM SPECT study in rats
DOI: 10.1016/j.nucmedbio.2011.11.006
Abstract: Introduction: Ex vivo storage phosphor imaging rat studies reported increased brain dopamine D2/3 receptor (DRD2/3) availability following treatment with varenicline, a nicotinergic drug. Ho...
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Cleo L. Crunelle,
Tim C. de Wit,
Kora de Bruin,
Ruud M. Ramakers,
Frans van der Have,
Freek J. Beekman,
Wim van den Brink,
Jan Booij
et al.
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Full-length article
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20 January 2012 |
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Evaluation of the relationship between [18F]FDG and P-glycoprotein expression: an experimental study
DOI: 10.1016/j.nucmedbio.2011.12.007
Abstract: Introduction: P-glycoprotein (P-gp) is a cell-membrane-associated protein that transports a variety of drug substrates. We sought to evaluate the relationship between 2-[18F]fluoro-2-deoxy-d...
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Chunjing Yu,
Weixing Wan,
Bin Zhang,
Shengming Deng,
Tzu-Chen Yen,
Yiwei Wu
et al.
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Full-length article
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20 January 2012 |