Current Issue February 2012, Vol. 39, No. 2

Issue Highlights

  • Synthesis and evaluation of [18F]exendin (9–39) as a potential biomarker to measure pancreatic β-cell mass
    February 2012(Vol. 39 | No. 2 | Pages 167-176)

    Yi Wang, Keunpoong Lim, Marc Normandin, Xiaojian Zhao, Gary W. Cline, Yu-Shin Ding

  • Radiolabeled Cu-ATSM as a novel indicator of overreduced intracellular state due to mitochondrial dysfunction: studies with mitochondrial DNA-less ρ0 cells and cybrids carrying MELAS mitochondrial DNA mutation
    February 2012(Vol. 39 | No. 2 | Pages 177-185)

    Yukie Yoshii, Makoto Yoneda, Masamichi Ikawa, Takako Furukawa, Yasushi Kiyono, Tetsuya Mori, Hiroshi Yoshii, Nobuyuki Oyama, Hidehiko Okazawa, Tsuneo Saga, Yasuhisa Fujibayashi

  • Evaluation of copper-64-labeled somatostatin agonists and antagonist in SSTr2-transfected cell lines that are positive and negative for p53: implications for cancer therapy
    February 2012(Vol. 39 | No. 2 | Pages 187-197)

    Kim Nguyen, Jesse J. Parry, Buck E. Rogers, Carolyn J. Anderson

  • Radiation dosimetry of the translocator protein ligands [18F]PBR111 and [18F]PBR102
    02 February 2012

    Jordan D. Verschuer, Jocelyn Towson, Stefan Eberl, Andrew Katsifis, David Henderson, Peter Lam, Lingfeng Wen, Christian Loc'h, Filomena Mattner, Sally Thomson, Armin Mohamed, Michael J. Fulham

  • A fast chemoenzymatic synthesis of [11C]-N5,N10-methylenetetrahydrofolate as a potential PET tracer for proliferating cells
    02 February 2012

    Muhammad Saeed, Timothy J. Tewson, Colbin E. Erdahl, Amnon Kohen

  • Evaluation of 68Ga-labeled tracers for PET imaging of myocardial perfusion in pigs
    20 January 2012

    Miikka Tarkia, Antti Saraste, Tiina Saanijoki, Vesa Oikonen, Tommi Vähäsilta, Marjatta Strandberg, Christoffer Stark, Tuula Tolvanen, Mika Teräs, Timo Savunen, Mark A. Green, Juhani Knuuti, Anne Roivainen

  • Quantification of regional cerebral blood flow in rats using an arteriovenous shunt and micro-PET
    20 January 2012

    Takayuki Ose, Hiroshi Watabe, Takuya Hayashi, Nobuyuki Kudomi, Masaaki Hikake, Hajime Fukuda, Noboru Teramoto, Yasuyoshi Watanabe, Hirotaka Onoe, Hidehiro Iida

  • A historical perspective on the specific activity of radiopharmaceuticals: what have we learned in the 35 years of the ISRC?
    20 January 2012

    Suzanne E. Lapi, Michael J. Welch

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About Nuclear Medicine and Biology

Nuclear Medicine and Biology publishes original research covering all aspects of radiopharmaceutical chemistry: synthesis, radiopharmacy, in vitro and ex vivo testing, and in vivo evaluation of molecular probes for PET, SPECT, planar imaging, and autoradiography. These multidisciplinary studies should demonstrate the mechanism of localization whether the radioactive substance is based on receptor, enzyme, tumor antigen, or other well-defined biochemistry. The study should also address the sensitivity of the probe to changes in biochemistry, although studies of mechanism alone are acceptable. Contributions on the subject of therapeutic radiopharmaceuticals also are appropriate provided that the specificity of labeled compound localization and therapeutic effect have been addressed. If the synthesis of a new radiopharmaceutical is submitted alone, then the uniqueness of the chemistry must be emphasized. Papers that describe instrumentation important to molecular imaging as well as papers describing translational clinical research and the issues of extending preclinical research to clinical studies are also welcome.

Society of Radiopharmaceutical Sciences

Society of Radiopharmaceutical Sciences is a multidisciplinary professional organization dedicated to the advancement of excellence in education and research in radiopharmaceutical chemistry and in the study and use of radiopharmaceuticals. The organization has been formed to foster meetings for the purpose of communicating and discussing information about radiopharmaceuticals as they apply to the better understanding and control of biological phenomena, both normal and pathological; to disseminate information concerning radiopharmaceutical sciences by sponsoring scientific and professional publications; and strive to improve the welfare of mankind by maintaining and advancing the highest possible standards of education, research, and the practice of radiopharmaceutical sciences.