Nuclear Medicine and Biology
Volume 39, Issue 1 , Pages 15-22 , January 2012

Comparison of therapeutic efficacy and biodistribution of 213Bi- and 211At-labeled monoclonal antibody MX35 in an ovarian cancer model

  • Anna M.E. Gustafsson

      Affiliations

    • Department of Radiation Physics, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46 31 342 97 36.
    • ,
  • Tom Bäck

      Affiliations

    • Department of Radiation Physics, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    • ,
  • Jörgen Elgqvist

      Affiliations

    • Department of Oncology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    • ,
  • Lars Jacobsson

      Affiliations

    • Department of Radiation Physics, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    • ,
  • Ragnar Hultborn

      Affiliations

    • Department of Oncology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    • ,
  • Per Albertsson

      Affiliations

    • Department of Oncology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    • ,
  • Alfred Morgenstern

      Affiliations

    • European Commission, Joint Research Centre, Institute for Transuranium Elements, Karlsruhe, Germany
    • ,
  • Frank Bruchertseifer

      Affiliations

    • European Commission, Joint Research Centre, Institute for Transuranium Elements, Karlsruhe, Germany
    • ,
  • Holger Jensen

      Affiliations

    • PET and Cyclotron Unit, Rigshospitalet, Copenhagen, Denmark
    • ,
  • Sture Lindegren

      Affiliations

    • Department of Radiation Physics, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Received 1 April 2011 ,Revised 23 June 2011 ,Accepted 6 July 2011.

  • Image Result

    White blood cell (WBC) counts before treatment, 5 days after treatment and 14 days after treatment. Each group consisted of five animals. Means and S.E.M. (error bars) are depicted.

    White blood cell (WBC) counts before treatment, 5 days after treatment and 14 days after treatment. Each group consisted of five animals. Means and S.E.M. (error bars) are depicted.

  • Image Result

    Biodistribution of 211At- and 213Bi-labeled monoclonal antibody MX35. Mice were injected with a mixture of 211At-MX35 and 213Bi-MX35, and data were collected 15 min (A), 45 min (B), 90 min (C) and 180

    Biodistribution of 211At- and 213Bi-labeled monoclonal antibody MX35. Mice were injected with a mixture of 211At-MX35 and 213Bi-MX35, and data were collected 15 min (A), 45 min (B), 90 min (C) and 180 min (D) after injection. Four animals were sacrificed at each time point. Tissue concentrations of radioactivity are expressed as the percentages of injected dose per gram (% ID/g). Means and S.E.M. (error bars) are depicted.

☆ This work was carried out with research grants from the Swedish Cancer Society (grant no. 3548), the Swedish Research Council (grant no. K2007-53X-20321-01-3) and the King Gustaf V Jubilee Clinic Research Foundation in Gothenburg, Sweden.

PII: S0969-8051(11)00162-4

doi: 10.1016/j.nucmedbio.2011.07.003

Nuclear Medicine and Biology
Volume 39, Issue 1 , Pages 15-22 , January 2012

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