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Volume 38, Issue 1 , Pages 13-17 , January 2011

The stability of methyl-, ethyl- and fluoroethylesters against carboxylesterases in vitro: there is no difference

Lukas Nics
- Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
- Department of Nutritional Sciences, University of Vienna, A-1090 Vienna, Austria
Daniela Haeusler
- Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
- Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, A-1090 Vienna, Austria
Wolfgang Wadsak
- Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
- Department of Inorganic Chemistry, University of Vienna, A-1090 Vienna, Austria
Karl-Heinz Wagner
- Department of Nutritional Sciences, University of Vienna, A-1090 Vienna, Austria
Robert Dudczak
- Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
Kurt Kletter
- Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
Markus Mitterhauser
- Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
- Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, A-1090 Vienna, Austria
- Hospital Pharmacy of the General Hospital of Vienna, A-1090 Vienna, Austria
- Corresponding author. Department of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria. Tel.: +43 1 40400 1557; fax: +43 1 40400 1559.

Received 31 May 2010 ,Revised 29 June 2010 ,Accepted 1 July 2010.

References

Satoh T, Hosokawa M. The mammalian carboxylesterases: from molecules to functions. Annu Rev Pharmacol Toxicol. 1998;38:257–288
- MEDLINE
- CrossRef
Satoh T, Hosokawa M. Structure, function and regulation of carboxylesterases. Chem Biol Interact. 2006;162(3):195–211
- MEDLINE
- CrossRef
Stoops JK, Hamilton SE, Zerner B. Carboxylesterases (EC 3.1.1). A comparison of some kinetic properties of horse, sheep, chicken, pig, and ox liver carboxylesterases. Can J Biochem. 1975;53(5):565–573
- MEDLINE
Mentlein R, Heiland S, Heymann E. Simultaneous purification and comparative characterization of six serine hydrolases from rat liver microsomes. Arch Biochem Biophys. 1980;200(2):547–559
- MEDLINE
- CrossRef
Ettlinger DE, Wadsak W, Mien LK, Machek M, Wabnegger L, Rendl G, et al. [¹⁸F]FETO: metabolic considerations. Eur J Nucl Med Mol Imaging. 2006;33(8):928–931
- MEDLINE
Ettlinger DE, Haeusler D, Wadsak W, Girschele F, Sindelar KM, Mien LK, et al. Metabolism and autoradiographic evaluation of [¹⁸F]FE@CIT: a comparison with [¹²³I]beta-CIT and [¹²³I]FP-CIT. Nucl Med Biol. 2008;35(4):475–479
Haeusler D, Nics L, Mien LK, Ungersboeck J, Lanzenberger RR, Shanab K, et al. [¹⁸F]FE@SUPPY and [¹⁸F]FE@SUPPY:2 metabolic considerations. Nucl Med Biol. 2010;37(4):421–426
Nics L, Haeusler D, Mien LK, Wadsak W, Ettlinger DE, El-Samahi H, et al. On the stability of radiolabelled esters: a carboxylesterase assay. [abstract] Eur J Nucl Med Mol Imaging. 2009;36(suppl.2):S395
Shanab K, Wadsak W, Mien LK, Mitterhauser M, Holzer W, Polster V, et al. Synthesis of in vivo metabolites of the new adenosine A3 receptor PET-radiotracer [¹⁸F]FE@SUPPY. Heterocycles. 2008;75(2):339–356
Theodoridis G. Novel applications of alkyl fluorides in organic synthesis: versatile nitrogen protecting groups. Tetrahedron Lett. 1998;39(51):9365–9368
- CrossRef
Wadsak W, Mien LK, Ettlinger DE, Eidherr H, Haeusler D, Sindelar KM, et al. ¹⁸F fluoroethylations: different strategies for the rapid translation of ¹¹C-methylated radiotracers. Nucl Med Biol. 2007;34(8):1019–1028