Nuclear Medicine and Biology
Volume 37, Issue 8 , Pages 935-942 , November 2010

Production of large quantities of 90Y by ion-exchange chromatography using an organic resin and a chelating agent

  • Abmel Xiques Castillo

      Affiliations

    • Centro de Isótopos (CENTIS), Ave. Monumental y Carretera La Rada Km 3 1/2, Guanabacoa, Havana, Cuba
    • Corresponding Author InformationCorresponding author.
    • ,
  • Marylaine Pérez-Malo

      Affiliations

    • Centro de Isótopos (CENTIS), Ave. Monumental y Carretera La Rada Km 3 1/2, Guanabacoa, Havana, Cuba
    • ,
  • Keila Isaac-Olivé

      Affiliations

    • Centro de Isótopos (CENTIS), Ave. Monumental y Carretera La Rada Km 3 1/2, Guanabacoa, Havana, Cuba
    • ,
  • Heyam Mukhallalati

      Affiliations

    • Division of Radiopharmaceuticals, Atomic Energy Commission of Syria, Damascus, Syria
    • Contributed partially to this work during her training as an IAEA fellow related to SYR/2/004 project.
    • ,
  • Edgar Casanova González

      Affiliations

    • Centro de Isótopos (CENTIS), Ave. Monumental y Carretera La Rada Km 3 1/2, Guanabacoa, Havana, Cuba
    • ,
  • Mirta Torres Berdeguez

      Affiliations

    • Centro de Isótopos (CENTIS), Ave. Monumental y Carretera La Rada Km 3 1/2, Guanabacoa, Havana, Cuba
    • ,
  • Néstor Cornejo Díaz

      Affiliations

    • Centro de Protección e Higiene de las Radiaciones, AP: 6195 Habana 6, CP 10600, Havana, Cuba

Received 25 September 2009 ,Revised 5 February 2010 ,Accepted 30 March 2010.

References 

  1. Kampen WU, Voth M, Pinkert J, Krause A. Therapeutic status of radiosynoviorthesis of the knee with yttrium [90Y] colloid in rheumatoid arthritis and related indications. Rheumatology (Oxford). 2007;46:16
  2. Gulec SA, Mesoloras G, Dezarn WA, McNeillie P, Kennedy AS. Safety and efficacy of Y-90 microsphere treatment in patients with primary and metastatic liver cancer: the tumor selectivity of the treatment as a function of the tumor to liver flow ratio. J Transl Med. 2007;5:15
  3. Paganelli G, Bartolomei M, Grana C, Ferrari M, Rocca P, Chinol M. Radioimmunotherapy of brain tumour. Neurol Res. 2006;28:518
  4. Witzig TE, Molina A, Gordon LI, Emmanouilides C, Schilder RJ, Flinn IW, et al. Long-term responses in patients with recurring or refractory B-cell non-Hodgkin lymphoma treated with yttrium 90 ibritumomab tiuxetan. Cancer. 2007;109:1804
  5. Davies AJ. Radioimmunotherapy for B-cell lymphoma: Y-90 ibritumomab tiuxetan and I-131 tositumomab. Oncogene. 2007;26:3614
  6. Grillo-Lopez AJ. Zevalin: the first radioimmunotherapy approved for the treatment of lymphoma. Expert Rev Anticancer Ther. 2002;2:485
  7. Sylvester P. Novel ion exchange materials for the separation of 90Y from 90Sr. U.S. Patent Application 20030231994. 2003;
  8. Dash A, Bhattacharyya PK. Preparation of a 90Sr–90Y generator using zirconium antimonate. Appl Radiat Isot. 1993;45:415
  9. Chinol M, Hnatowich DJ. Generator produced yttrium-90 for radioimmunotherapy. J Nucl Med. 1987;28:1465
  10. Skraba WJ, Arino H, Kramer HH. A new 90Sr/90Y radioisotope generator. Int J Appl Radiat Isot. 1978;29:91
  11. Chinol M, Francceschini R, Paganelli G. Process for producing yttrium-90-labelled protein substrate. U.S. Patent 5902566. 1999;
  12. Doering RF, Tucker WD. A simple device for milking high purity 90Y from 90Sr. J Nucl Med. 1963;4:54
  13. Suzuki Y. Preparation of carrier-free 90Y from 90Sr with ion-exchange. Int J Appl Radiat Isot. 1964;15:599
  14. Malja S, Schomacker K, Malja E. Preparation of 90Y by the 90Sr–90Y generator for medical purpose. J Radioanal Nucl Chem. 2000;245:403
  15. Kanapilly GM, Newton GJ. A new method for the separation of multicurie quantities of 90Y from 90Sr. Int J Appl Radiat Isot. 1970;22:567
  16. Wike JS, Guyer CE, Ramey DW, Phillips BP. Chemistry for commercial scale production of yttrium-90 for medical research. Appl Radiat Isot. 1990;41:861
  17. Kodina GE. Production of high-purity 90Y on specially developed centrifugal semicounterflow extractors. Radiochemistry. 2002;44:61
  18. Chakravarty R, Pandey U, Manolkar RB, Dash A, Venkatesh M, Pillai MRA. Development of an electrochemical 90Sr–90Y generator for separation of 90Y suitable for targeted therapy. Nucl Med Biol. 2008;35:245
  19. Wester DW, Steele RT, Rinehart DE, Des Chane JR, Carson KJ, Rapko BM, et al. Large-scale purification of 90Sr from nuclear waste materials for production of 90Y, a therapeutic medical radioisotope. Appl Radiat Isot. 2003;59:35
  20. Bray LA. Method for separating and purifying Yttrium-90 from Strontium-90. WO 2006/025975. World Intellectual Property Organization; 2006;
  21. Dietz LM, Horwitz EP. Improved chemistry for production of yttrium-90 for medical applications. Appl Radiat Isot. 1992;43:1093
  22. Boll RA, Malkemus D, Mirzadeh S. Production of actinium-225 for alpha particle mediated radioimmunotherapy. Appl Radiat Isot. 2005;62:667
  23. L'Annunziata MF. Liquid scintillation analysis: principles and practice. Multiple radionuclide analysis. In: Handbook of radioactivity analysis. 2nd ed.. London, Great Britain: Academic Press; 2003;p. 418
  24. L'Annunziata MF. Liquid scintillation analysis: principles and practice. Radionuclide standardization. In: Handbook of radioactivity analysis. 2nd ed.. London, Great Britain: Academic Press; 2003;p. 445
  25. Nowack B, Kari FG, Hilger SU, Sigg L. Determination of dissolved and adsorbed EDTA species in water and sediments by HPLC. Anal Chem. 1996;68:561
  26. Xiques CA, Isaac-Olive K, Casanova GE, Beckford D, Leyva MR, Montero AA, et al. An adapted purification procedure to improve the quality of 90Y for clinical use. Radiochim Acta. 2009;97:739
  27. Cross WG, Freedman NO, Wong PY. Table of beta-ray dose distribution in water. Atomic Energy of Canada AECL-Report 10521. 1992;
  28. Briesmeister JF. MCNP — a general Monte Carlo N-particle transport code, version 4C. CCC-700. Los Alamos, New Mexico.: Los Alamos National Laboratory; 2000;
  29. Simpkin DJ, Mackie TR. EGS4 Monte Carlo determination of the beta dose kernel in water. Med Phys. 1990;17:179
  30. Bhattacharyya SN, Kurdu KP. X-Irradiation of aqueous solutions of ethylenediaminetetraacetic acid (EDTA). J Radioanal Nucl Chem. 1972;4:31
  31. Höbel B, Sonntag C. OH-Radical induced degradation of ethylenediaminetetraacetic acid (EDTA) in aqueous solution: a pulse radiolysis study. J Chem Soc Perkin Trans. 1998;2:509
  32. Toste AP. Gamma radiolysis of EDTA in a simulated, mixed nuclear waste. J Radioanal Nucl Chem. 1998;235:213
  33. USP monographs: yttrium Y-90 ibritumomab tiuxetan injection. http://www.pharmacopeia.cn/v29240/usp29nf24s0_m89430.html
  34. Pillay KKS. A review of the radiation stability of ion exchange materials. J Radioanal Nucl Chem. 1986;102:247
  35. Van Loon LR, Hummel W. The radiolytic and chemical degradation of organic ion exchange resins under alkaline conditions. Paul Scherrer Institute, Technical Report. Würenlingen and Villigen 1995, p.6.
  36. Frizon F, Cau-dit-Coumes C. Cementation of ILW ion exchange resins: impact of sulfate ions released by radiolysis on hydrated matrix. J Nucl Mat. 2006;359:162
  37. Marhol M. In: Ion exchangers in analytical chemistry. Prague: Academia Praga; 1982;p. 25

PII: S0969-8051(10)00317-3

doi: 10.1016/j.nucmedbio.2010.03.017

Nuclear Medicine and Biology
Volume 37, Issue 8 , Pages 935-942 , November 2010

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