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Nuclear Medicine and Biology
Volume 37, Issue 5
, Pages 577-586
, July 2010
FlipADAM: a potential new SPECT imaging agent for the serotonin transporter
References
- . Selectivity of antidepressants: from the monoamine hypothesis of depression to the SSRI revolution and beyond. J Clin Psychiatry. 2004;4:5–10
- . The burden of severe depression: a review of diagnostic challenges and treatment alternatives. J Psychiatr Res. 2006;
- . Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat Struct Mol Biol. 2009;16:652–657
- Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [11C]DASB PET imaging study. Am J Psychiatry. 2001;158:1843–1849
- . [11C]-DASB, a tool for in vivo measurement of SSRI-induced occupancy of the serotonin transporter: PET characterization and evaluation in cats. Synapse. 2003;47:123–133
- Synthesis and in vivo evaluation of [O-methyl-11C](2R,4R)-4-hydroxy-2-[2-[2-[2-(3-methoxy)phenyl]ethyl]phenoxy]ethyl-1-methylpyrrolidine as a 5-HT2A receptor PET ligand. Nucl Med Biol. 2006;33:565–574
- Imaging the serotonin transporter using (123)I-ADAM in the human brain. Psychiatry Res. 2009;172:38–43
- Brain serotonin transporter binding of [123I]ADAM: within-subject variation between summer and winter data. Chronobiol Int. 2008;25:657–665
- [I-123] ADAM and SPECT in patients with borderline personality disorder and healthy control subjects. J. Psychiatry Neurosci. 2007;32:234–240
- Increased serotonin transporter availability in the brainstem of migraineurs. J Neurol. 2007;254:789–796
- . Association between serotonin transporter availability and hostility scores in healthy volunteers - a single photon emission computed tomography study with [(123)I] ADAM. Psychiatry Res. 2007;154:281–284
- Serotonin transporter occupancy induced by paroxetine in patients with major depression disorder: a 123I-ADAM SPECT study. Psychopharmacology (Berl). 2006;189:145–153
- Effects of citalopram infusion on the serotonin transporter binding of [11C]DASB in healthy controls. J Cereb Blood Flow Metab. 2008;28:1478–1490
- PET [11C]DASB imaging of serotonin transporters in patients with alcoholism. Alcohol Clin Exp Res. 2007;31:28–32
- Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: reproducibility and comparison of methods. J Nucl Med. 2006;47:815–826
- . Synthesis and biological evaluation of one novel technetium-99m-labeled nitroquipazine derivative as an imaging agent for serotonin transporter. Appl Radiat Isot. 2008;66:1804–1809
- Synthesis of a fluorine-18-labelled derivative of 6-nitroquipazine, as a radioligand for the In vivo serotonin transporter imaging with PET. Bioorg Med Chem. 2002;10:2611–2623
- . Autoradiographic imaging of the serotonin transporter in the brain of rats and pigs using S-([18F]fluoromethyl)-(+)-McN5652. Eur Neuropsychopharmacol. 2003;13:387–397
- . Effects of aging on serotonin transporter availability and its response to fluvoxamine in the living brain: PET study with [(11)C](+)McN5652 and [(11)C](-)McN5652 in conscious monkeys. Synapse. 2001;40:170–179
- . Serotonin transporter binding with [123I]beta-CIT SPECT in major depressive disorder versus controls: effect of season and gender. Eur J Nucl Med Mol Imaging. 2009;36:841–849
- Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3′-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. J Med Chem. 2008;51:7788–7799
- Reduced midbrain serotonin transporter availability in drug-naive patients with depression measured by SERT-specific [(123)I] nor-beta-CIT SPECT imaging. Psychiatry Res. 2007;154:125–131
- . In vivo characterization of a series of 18F-diaryl sulfides (18F-2-(2′-((dimethylamino)methyl)-4′-(fluoroalkoxy)phenylthio)benzenamine) for PET imaging of the serotonin transporter. J Nucl Med. 2009;50:1509–1517
- . 2-(2′-((Dimethylamino)methyl)-4′-(3-[(18)F]fluoropropoxy)-phenylthio)benze namine for positron emission tomography imaging of serotonin transporters. Nucl Med Biol. 2008;35:447–458
- . 2-(2′-((Dimethylamino)methyl)-4′-(fluoroalkoxy)-phenylthio)benzenamine Derivatives as Serotonin Transporter Imaging Agents. J Med Chem. 2007;50:6673–6684
- Docking study, synthesis, and in vitro evaluation of fluoro-MADAM derivatives as SERT ligands for PET imaging. Bioorg Med Chem. 2008;16:9050–9055
- The new PET imaging agent [11C]AFE is a selective serotonin transporter ligand with fast brain uptake kinetics. Nucl Med Biol. 2004;31:983–994
- A PET imaging agent with fast kinetics: synthesis and in vivo evaluation of the serotonin transporter ligand [11C]2-[2-dimethylaminomethylphenylthio)]-5-fluorophenylamine ([11C]AFA). Nucl Med Biol. 2004;31:727–738
- N,N-dimethyl-2-(2-amino-4-(18)F-fluorophenylthio)-benzylamine (4-(18)F-ADAM): an improved PET radioligand for serotonin transporters. J Nucl Med. 2003;44:1890–1897
- . New PET Imaging Agent for the Serotonin Transporter: [18F]ACF (2-[(2-Amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine). J Med Chem. 2002;45:4716–4723
- . Quantification of 11C-MADAM binding to the serotonin transporter in the human brain. J Nucl Med. 2005;46:1505–1515
- Synthesis and characterization of EADAM: a selective radioligand for mapping the brain serotonin transporters by positron emission tomography. Nucl Med Biol. 2005;32:75–86
- Carbon-11 HOMADAM: a novel PET radiotracer for imaging serotonin transporters. Nucl Med Biol. 2005;32:211–224
- . Characterization of [123I]IDAM as a novel single-photon emission tomography tracer for serotonin transporters. Eur J Nucl Med. 1999;26:844–853
- Selective in vitro and in vivo binding of [(125)I]ADAM to serotonin transporters in rat brain. Synapse. 2000;38:403–412
- 2-(2-(dimethylaminomethyl)phenoxy)-5-iodophenylamine: an improved serotonin transporter imaging agent. J Med Chem. 2004;47:5258–5264
- . Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of 11C-labeled 2-(phenylthio)araalkylamines. J Med Chem. 2000;43:3103–3110
- Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands. Bioorg Med Chem Lett. 2006;16:1297–1300
- . Brust P, et al. [11C]SMe-ADAM, an imaging agent for the brain serotonin transporter: synthesis, pharmacological characterization and microPET studies in rats. Nucl Med Biol. 2006;33:53–63
- . A new single-photon emission computed tomography imaging agent for serotonin transporters: [123I] IDAM, 5-Iodo-2-((2-((dimethylamino)methyl)phenyl)thio)benzyl alcohol. J Med Chem. 1999;42:333–335
- 2-((2-((Dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter ligand. Nucl Med Biol. 2000;27:249–254
- . Brain kinetics of the new selective serotonin transporter tracer [(123)I]ADAM in healthy young adults. Nucl Med Biol. 2006;33:185–191
- Brain SPECT imaging and whole-body biodistribution with [(123)I]ADAM — a serotonin transporter radiotracer in healthy human subjects. Nucl Med Biol. 2006;33:193–202
- Biodistribution and imaging with (123)I-ADAM: a serotonin transporter imaging agent. J Nucl Med. 2004;45:834–841
- Binding kinetics of 123 I[ADAM] in healthy controls: a selective SERT radioligand. Int J Neuropsychopharmacol. 2006;1–8
- SPECT of serotonin transporters using 123I-ADAM: optimal imaging time after bolus injection and long-term test-retest in healthy volunteers. J Nucl Med. 2005;46:1301–1309
- 123I-ADAM binding to serotonin transporters in patients with major depression and healthy controls: a preliminary study. J Nucl Med. 2005;46:973–977
- Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT study. Psychopharmacology (Berl). 2007;191:333–339
- Serotonin transporter binding of [123I]ADAM in bulimic women, their healthy twin sisters, and healthy women: a SPET study. BMC psychiatry. 2007;7:19
- . 123I-ADAM SPECT imaging of serotonin transporter binding in patients with night eating syndrome: a preliminary report. Psychiatry Res. 2008;162:214–220
- [123I] ADAM brainstem binding correlates with the loudness dependence of auditory evoked potentials. Eur Arch Psychiatry Clin Neurosci. 2008;258:40–47
- Dual-isotope single-photon emission computed tomography for dopamine and serotonin transporters in normal and Parkinsonian monkey brains. Nucl Med Biol. 2009;36:605–611
- Measuring SSRI occupancy of SERT using the novel tracer [123I]ADAM: a SPECT validation study. Eur J Nucl Med Mol Imaging. 2005;32:1329–1336
- Comparative evaluation in nonhuman primates of five PET radiotracers for imaging the serotonin transporters: [11C]McN 5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM. J Cereb Blood Flow Metab. 2002;22:1377–1398
- . 5-Chloro-2-(2′-((dimethylamino)methyl)-4′-iodophenylthio)benzenamine: a new serotonin transporter ligand. Nucl Med Biol. 2007;34:129–139
- Characterization of the binding sites for 123I-ADAM and the relationship to the serotonin transporter in rat and mouse brains using quantitative autoradiography. J Nucl Med. 2004;45:673–681
- Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines. Neuropsychopharmacology. 2006;31:2639–2651
- . Pharmacology and distribution of norepinephrine transporters in the human locus coeruleus and raphe nuclei. J Neurosci. 1997;17:1710–1719
☆ Financial support: This work was supported by a grant awarded from the National Institutes of Health (ROI-MH068782, H.F.K.).
PII: S0969-8051(10)00035-1
doi: 10.1016/j.nucmedbio.2010.02.010
© 2010 Elsevier Inc. All rights reserved.
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Nuclear Medicine and Biology
Volume 37, Issue 5
, Pages 577-586
, July 2010
