Nuclear Medicine and Biology
Volume 37, Issue 5 , Pages 557-564, July 2010

Synthesis and biological evaluation of a 99mTc-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase IX expression in tumor hypoxia

  • Vamsidhar Akurathi

      Affiliations

    • Laboratory for Radiopharmacy, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    • ,
  • Ludwig Dubois

      Affiliations

    • Department of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, University of Maastricht, 6200 Maastricht, The Netherland
    • ,
  • Natasja G. Lieuwes

      Affiliations

    • Department of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, University of Maastricht, 6200 Maastricht, The Netherland
    • ,
  • Satish K. Chitneni

      Affiliations

    • Department of Radiology, Duke University Medical Centre, Durham, NC 27710, USA
    • ,
  • Bernard J. Cleynhens

      Affiliations

    • Laboratory for Radiopharmacy, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    • ,
  • Daniela Vullo

      Affiliations

    • Universita degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, 50019 Sesto Fiorentino, Florence, Italy
    • ,
  • Claudiu T. Supuran

      Affiliations

    • Universita degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, 50019 Sesto Fiorentino, Florence, Italy
    • ,
  • Alfons M. Verbruggen

      Affiliations

    • Laboratory for Radiopharmacy, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    • ,
  • Philippe Lambin

      Affiliations

    • Department of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, University of Maastricht, 6200 Maastricht, The Netherland
    • ,
  • Guy M. Bormans

      Affiliations

    • Laboratory for Radiopharmacy, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    • Corresponding Author InformationCorresponding author. Post box 821, O&N2, Herestraat 49, BE-3000 Leuven, Belgium. Tel.: +32 0 16 330447; fax: +32 0 16 330449.

Received 26 October 2009; received in revised form 23 February 2010; accepted 28 February 2010. published online 26 April 2010.

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PII: S0969-8051(10)00031-4

doi:10.1016/j.nucmedbio.2010.02.006

Nuclear Medicine and Biology
Volume 37, Issue 5 , Pages 557-564, July 2010

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