Nuclear Medicine and Biology
Volume 37, Issue 4 , Pages 433-438, May 2010

Investigation of the pharmacokinetics of 3′-deoxy-3′-[18F]fluorothymidine uptake in the bone marrow before and early after initiation of chemoradiation therapy in head and neck cancer☆

  • Yusuf Menda

      Affiliations

    • Division of Nuclear Medicine, Department of Radiology, University of Iowa Hospitals and Clinics Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 319 356 3214; fax: +1 319 356 2220.
    • ,
  • Laura L. Boles Ponto

      Affiliations

    • Division of Nuclear Medicine, Department of Radiology, University of Iowa Hospitals and Clinics Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • ,
  • Kenneth J. Dornfeld

      Affiliations

    • Department of Radiation Oncology, University of Iowa Hospitals and Clinics Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • ,
  • Timothy J. Tewson

      Affiliations

    • Division of Nuclear Medicine, Department of Radiology, University of Iowa Hospitals and Clinics Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • ,
  • G. Leonard Watkins

      Affiliations

    • Division of Nuclear Medicine, Department of Radiology, University of Iowa Hospitals and Clinics Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • ,
  • Anjali K. Gupta

      Affiliations

    • Department of Radiation Oncology, University of Iowa Hospitals and Clinics Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • ,
  • Carryn Anderson

      Affiliations

    • Department of Radiation Oncology, University of Iowa Hospitals and Clinics Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • ,
  • Sarah McGuire

      Affiliations

    • Department of Radiation Oncology, University of Iowa Hospitals and Clinics Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • ,
  • Michael K. Schultz

      Affiliations

    • Division of Nuclear Medicine, Department of Radiology, University of Iowa Hospitals and Clinics Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • ,
  • John J. Sunderland

      Affiliations

    • Division of Nuclear Medicine, Department of Radiology, University of Iowa Hospitals and Clinics Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • ,
  • Michael M. Graham

      Affiliations

    • Division of Nuclear Medicine, Department of Radiology, University of Iowa Hospitals and Clinics Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    • ,
  • John M. Buatti

      Affiliations

    • Department of Radiation Oncology, University of Iowa Hospitals and Clinics Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA

Received 5 November 2009; received in revised form 20 February 2010; accepted 28 February 2010.

Abstract 

Introduction

The kinetics of the bone marrow uptake of 3′-deoxy-3′-[18F]fluorothymidine (FLT) before and early after initiation of chemoradiation therapy was investigated in patients with head and neck cancer.

Methods

Fourteen subjects with head and neck cancer underwent FLT positron emission tomography (PET) at baseline and after 10 Gy of radiation therapy. Thirteen subjects also received one cycle of platinum-based chemotherapy before the second FLT PET. Kinetic parameters, including the flux constant based on compartmental analysis (KFLT) and the Patlak constant (KPatlak) for cervical marrow, were calculated. Standardized uptake values (SUVs) for the cervical marrow (inside the radiation field) and lumbar spine marrow (outside the radiation field) were also determined.

Results

There was a significant drop in FLT uptake in the bone marrow inside the radiation field. Mean pretreatment uptake values for the cervical spine were SUV=3.08±0.66, KFLT=0.045±0.016 min−1 and KPatlak=0.039±0.013 min−1. After treatment, these values were SUV=0.74±0.19, KFLT=0.011±0.005 min−1 and KPatlak=0.005±0.002 min−1. Compartmental analysis revealed a significant drop in k3 in irradiated cervical marrow. FLT uptake in the bone marrow outside the radiation field exhibited a significantly smaller decrease.

Conclusions

There is a marked decrease in FLT uptake in irradiated bone marrow after 10 Gy of radiation therapy to the head and neck. The drop in FLT uptake in irradiated marrow is due to a significant decrease in the net phosphorylation rate of FLT.

Keywords: 3′-Deoxy-3′-[18F]fluorothymidine, FLT, Bone marrow, Chemoradiation

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☆ Part of this study was presented at the Academy of Molecular Imaging/Society for Molecular Imaging Joint Molecular Imaging Conference 2007 in Providence, RI, and at the Society of Nuclear Medicine 2009 Annual Meeting in Toronto, Ontario, Canada.

PII: S0969-8051(10)00030-2

doi:10.1016/j.nucmedbio.2010.02.005

Nuclear Medicine and Biology
Volume 37, Issue 4 , Pages 433-438, May 2010

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