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Nuclear Medicine and Biology
Volume 37, Issue 3
, Pages 277-288
, April 2010
Synthesis and evaluation of a technetium-99m labeled cytotoxic bombesin peptide conjugate for targeting bombesin receptor-expressing tumors
References
- . Isolation and structure of bombesin and alytesin, two analogous active peptides from the skin of the European amphibians Bombina and Alytes. Experientia. 1971;27:166–167
- Preclinical comparison of 111In-labeled DTPA- or DOTA-bombesin analogs for receptor targeted scintigraphy and radionuclide therapy. J Nucl Med. 2002;43:1650–1656
- CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung. Proc Natl Acad Sci U S A. 1991;88:10662–10666
- . Radiolabeled bombesin analogs for prostate cancer diagnosis: preclinical studies. Nucl Med Biol. 2008;35:401–411
- . Potent bombesin antagonists with C-terminal Leu-ψ(CH2-N)-Tac-NH2 or its derivatives. Proc Natl Acad Sci U S A. 1994;91:12664–12668
- Identification of key amino acids in the gastrin-releasing peptide receptor (GRPR) responsible for high affinity binding of gastrin-releasing peptide (GRP). Biochem Pharmacol. 2005;69:579–593
- . In vitro and in vivo evaluation of 64Cu-labeled DOTA-linker-bombesin(7–14) analogues containing different amino acid linker moieties. Bioconjug Chem. 2007;18:1110–1117
- . Radiolabeled peptide conjugates for targeting of the bombesin receptor superfamily subtypes. Nucl Med Biol. 2005;32:733–740
- . Gastrin-releasing peptide receptors in normal and neoplastic human uterus: involvement of multiple tissue compartments. J Clin Endocrinol Metab. 2005;90:4722–4729
- . Bombesin receptors in distinct tissue compartments of human pancreatic diseases. Lab Invest. 2000;80:1807–1817
- . Bombesin receptor subtypes in human cancers: detection with the universal radioligand 125I-[D-TYR6-β-ALA11, PHE13, NLE14] bombesin(6-14). Clin Cancer Res. 2002;8:1139–1146
- Evaluation of the pharmacokinetic effects of various linking group using the 111In-DOTA-X-BBN(7–14)NH2 structural paradigm in a prostate cancer model. Bioconjug Chem. 2008;19:1803–1812
- . Synthesis and evaluation of bombesin derivatives on the basis of pan-bombesin peptides with indium-111, leutetium-177, and yttrium-90 for targeting bombesin receptor-expressing tumors. Cancer Res. 2004;64:6707–6715
- . Peptide-based radiopharmaceuticals and cytotoxic conjugates: potential tools against cancer. Cancer Treat Rev. 2008;34:13–26
- . New approaches to treatment of various cancers based on cytotoxic analogs of LHRH, somatostatin and bombesin. Life Sci. 2003;72:2305–2320
- . Cancer chemotherapy based on targeting of cytotoxic peptide conjugates to their receptors on tumors. Eur J Endocrinol. 1999;141:1–14
- . Design, synthesis, and in vitro evaluation of cytotoxic analogs of bombesin-like peptides containing doxorubicin or its intensely potent derivative, 2-pyrrolinodoxorubicin. Proc Natl Acad Sci U S A. 1997;94:652–656
- Nunn A D. 177Lu-AMBA: synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer. J Nucl Med. 2006;47:1144–1152
- Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with other mammalian bombesin receptors. J Biol Chem. 1997;272:26062–26071
- Identification of a unique ligand which has high affinity for all four bombesin receptor subtypes. Eur J Pharmacol. 1998;343:275–287
- . Selective coupling of methotrexate to peptide hormone carriers through a γ-carboxamide linkage of its glutamic acid moiety: benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate activation in salt coupling. Proc Natl Acad Sci. 1993;90:6373–6376
- . Ode to methotrexate. J Clin Oncol. 1993;11:5–14
- . Imaging tumor folate receptors using 111In-DTPA-methotrexate. Cancer Biother Radiopharm. 1998;13:177–184
- . Candidates for peptide receptor radiotherapy today and in the future. J Nucl Med. 2005;46:67S–75S
- . Synthetic peptides. New York: Oxford University Press; 2002;
- . Synthesis, radiolabeling and in vitro and in vivo characterization of a technetium-99m-labeled alpha-M2 peptide as a tumor imaging agent. J Peptide Res. 2004;63:460–468
- . Comparison of the stability of technetium-labeled peptides to challenge with cysteine. Bioconjug Chem. 1999;10:130–136
- a new chelator-coupled somatostatin analogue labeled with [67/68Ga] and [111In] for SPECT, PET, and targeted therapeutic applications of somatostatin receptor (hsst2) expressing tumors. Bioconjug Chem. 2002;13:530–541
- . Preparation and in vitro and in vivo evaluation of technetium-99-labeled folate and methotrexate conjugates as tumor imaging agents. Cancer Biother Radiopharm. 2006;21:49–60
- . Development and validation of a liquid chromatographic method for the analysis of positron emission tomography radiopharmaceuticals with Ru(bpy)32+-KMnO4. Anal Sci. 2007;23:151–155
- . Sensitive determination of specific radioactivity of positron emission tomography radiopharmaceuticals by radio high-performance liquid chromatography with fluorescence detection. Nucl Med Biol. 2008;35:733–740
- Potential of [11C]DASB for measuring endogenous serotonin with PET: binding studies. Nucl Med Biol. 2005;32:129–136
- Characterization of receptors for α-melanocyte-stimulating hormone on human melanoma cells. Cancer Res. 1989;49:6352–6358
- Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press; 1996;
- . In: Technetium-99m labelled hybrid receptor-binding peptides. Technetium and rhenium in chemistry and nuclear medicine. Padova (Italy): SG Editoriali; 1995;p. 491–497
- In: Technetium-99m chelate-containing receptor-binding peptides. Technetium and rhenium in chemistry and nuclear medicine. Padova (Italy): SG Editoriali; 1995;p. 269–274
- . Comparative in vitro and in vivo evaluation of two 64Cu-labeled bombesin analogs in a mouse model of human prostate adenocarcinoma. Nucl Med Biol. 2006;33:371–380
- . True radiotracers: Cu-64 targeting vectors based upon bombesin peptide. Nucl Med Biol. 2009;36:579–585
- . Characterization of bombesin/gastrin-releasing peptide receptors in human breast cancer and their relationship to steroid receptor expression. Cancer Res. 1995;55:280–287
- Characterization, in some human breast cancer cell lines, of gastrin-releasing peptide-like receptors which are absent in normal breast epithelial cells. Int J Cancer. 1990;46:293–298
- . Characterization of high-affinity receptors for bombesin/gastrin releasing peptide on the human prostate cancer cell lines PC-3 and DU-145: internalization of receptor bound 125I-(Tyr4) bombesin by tumor cells. Prostate. 1994;25:29–38
- . Transport of methotrexate into PC-3 human prostate cancer cells. Arch Biochem Biophys. 2001;394:39–44
- . Role of the membrane-associated folate binding protein (folate receptor) in methotrexate transport by human KB cells. Arch Biochem Biophys. 1989;274:327–337
- Novel series of 111In-labeled bombesin analogs as potential radiopharmaceuticals for specific targeting of gastrin-releasing peptide receptors expressed on human prostate cancer cells. J Nucl Med. 2003;44:823–831
- . Molecular imaging and therapy of cancer using radiolabelled peptides. EJHP. 2005;01:20–21
- . Safe and effective inhibition of renal uptake of radiolabelled octreotide by a combination of lysine and arginine. Eur J Nucl Med. 2003;30:9–15
PII: S0969-8051(09)00296-0
doi: 10.1016/j.nucmedbio.2009.12.006
© 2010 Elsevier Inc. All rights reserved.
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Nuclear Medicine and Biology
Volume 37, Issue 3
, Pages 277-288
, April 2010
