Nuclear Medicine and Biology
Volume 37, Issue 3 , Pages 357-363 , April 2010

In vivo and in vitro characterization of [18F]-FE-(+)-DTBZ as a tracer for beta-cell mass

  • Olof Eriksson

      Affiliations

    • Division of Radiology, Department of Oncology, Radiology and Clinical Immunology, University Hospital, 751 87 Uppsala, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46 070 903054; fax: +46 18 666879.
    • ,
  • Mahabuba Jahan

      Affiliations

    • Department of Clinical Neuroscience, Karolinska Institute, Section of Psychiatry, Karolinska Hospital, 171 76, Stockholm, Sweden
    • ,
  • Peter Johnström

      Affiliations

    • Department of Clinical Neuroscience, Karolinska Institute, Section of Psychiatry, Karolinska Hospital, 171 76, Stockholm, Sweden
    • CNS & Pain Control, AstraZeneca R&D, 151 36, Södertälje, Sweden
    • ,
  • Olle Korsgren

      Affiliations

    • Department of Oncology, Radiology and Clinical Immunology, Division of Clinical Immunology, University Hospital, 751 87 Uppsala, Sweden
    • ,
  • Anders Sundin

      Affiliations

    • Division of Radiology, Department of Oncology, Radiology and Clinical Immunology, University Hospital, 751 87 Uppsala, Sweden
    • Department of Radiology, Karolinska University Hospital, 171 76, Stockholm, Sweden
    • ,
  • Christer Halldin

      Affiliations

    • Department of Clinical Neuroscience, Karolinska Institute, Section of Psychiatry, Karolinska Hospital, 171 76, Stockholm, Sweden
    • ,
  • Lars Johansson

      Affiliations

    • Division of Radiology, Department of Oncology, Radiology and Clinical Immunology, University Hospital, 751 87 Uppsala, Sweden
    • AstraZeneca R&D, 431 50, Mölndal, Sweden

Received 28 October 2009 ,Revised 3 December 2009 ,Accepted 6 December 2009.

References 

  1. Kahn SE, Carr DB, Faulenbach MV, Utzschneider KM. An examination of beta-cell function measures and their potential use for estimating beta-cell mass. Diabetes Obes Metab. 2008;10(Suppl 4):63–76[Review]
  2. Sweet IR, Cook DL, Lernmark A, Greenbaum CJ, Krohn KA. Non-invasive imaging of beta cell mass: a quantitative analysis. Diabetes Technol Ther. 2004;6(5):652–659
  3. DaSilva JN, Kilbourn MR, Mangner TJ. Synthesis of [11C]tetrabenazine, a vesicular monoamine uptake inhibitor, for PET imaging studies. Appl Radiat Isot. 1993;44(4):673–676
  4. Anlauf M, Eissele R, Schäfer MK, Eiden LE, Arnold R, Pauser U, et al. Expression of the two isoforms of the vesicular monoamine transporter (VMAT1 and VMAT2) in the endocrine pancreas and pancreatic endocrine tumors. J Histochem Cytochem. 2003;51(8):1027–1040
  5. Simpson NR, Souza F, Witkowski P, Maffei A, Raffo A, Herron A, et al. Visualizing pancreatic beta-cell mass with [11C]DTBZ. Nucl Med Biol. 2006;33(7):855–864
  6. Freeby M, Goland R, Ichise M, Maffei A, Leibel R, Harris P. VMAT2 quantitation by PET as a biomarker for beta-cell mass in health and disease. Diabetes Obes Metab. 2008;10(Suppl 4):98–108
  7. Goland R, Freeby M, Parsey R, Saisho Y, Kumar D, Simpson N, et al. 11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls. J Nucl Med. 2009;50(3):382–389[Epub 2009 Feb 17]
  8. Goswami R, Ponde DE, Kung MP, Hou C, Kilbourn MR, Kung HF. Fluoroalkyl derivatives of dihydrotetrabenazine as positron emission tomography imaging agents targeting vesicular monoamine transporters. Nucl Med Biol. 2006;33(6):685–694
  9. Zhang MR, Tsuchiyama A, Haradahira T, Yoshida Y, Furutsuka K, Suzuki K. Development of an automated system for synthesizing 18F-labeled compounds using [18F]fluoroethyl bromide as a synthetic precursor. Appl Radiat Isot. 2002;57(3):335–342
  10. Lammertsma AA, Hume SP. Simplified reference tissue model for PET receptor studies. Neuroimage. 1996;4(3 Pt 1):153–158
  11. Scherman D, Raisman R, Ploska A, Agid Y. [3H]dihydrotetrabenazine, a new in vitro monoaminergic probe for human brain. J Neurochem. 1988;50(4):1131–1136
  12. Lindhe O, Sundin A, Ulin J, Rahman O, Långström B, Sörensen J. [18F]Fluoroacetate is not a functional analogue of [11C]acetate in normal physiology. Eur J Nucl Med Mol Imaging. 2009;36(9):1453–1459[Epub 2009 Apr 22]
  13. Kilbourn MR, Hockley B, Lee L, Hou C, Goswami R, Ponde DE, et al. Pharmacokinetics of [18F]fluoroalkyl derivatives of dihydrotetrabenazine in rat and monkey brain. Nucl Med Biol. 2007;34(3):233–237

PII: S0969-8051(09)00294-7

doi: 10.1016/j.nucmedbio.2009.12.004

Nuclear Medicine and Biology
Volume 37, Issue 3 , Pages 357-363 , April 2010

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