Nuclear Medicine and Biology
Volume 37, Issue 3 , Pages 327-333, April 2010

18F-FDG PET/CT-related metabolic parameters and their value in early prediction of chemotherapy response in a VX2 tumor model☆☆☆

  • Shao-li Song

      Affiliations

    • Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
    • Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine (SJTUSM) & Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, 200025, China
    • ,
  • Chuang Deng

      Affiliations

    • Power Grid Telecom and Automation Center, Sichuan Electric Power Corporation, Chengdu 610041, China
    • ,
  • Ling-feng Wen

      Affiliations

    • Department of PET and Nuclear Medicine, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
    • School of Information Technologies, The University of Sydney, NSW 2006, Sydney, Australia
    • ,
  • Jian-jun Liu

      Affiliations

    • Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
    • Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine (SJTUSM) & Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, 200025, China
    • ,
  • Hui Wang

      Affiliations

    • Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
    • Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine (SJTUSM) & Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, 200025, China
    • ,
  • David Feng

      Affiliations

    • School of Information Technologies, The University of Sydney, NSW 2006, Sydney, Australia
    • ,
  • Ching-yee Oliver Wong

      Affiliations

    • Positron Diagnostic Center and Medical Cyclotron, Department of Nuclear Medicine, William Beaumont Hospital, Royal Oak, MI 48073-6769, USA
    • ,
  • Gang Huang

      Affiliations

    • Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
    • Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine (SJTUSM) & Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, 200025, China
    • Corresponding Author InformationCorresponding author. Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China. Tel.: +86 021 63853125.

Received 20 October 2009; received in revised form 15 November 2009; accepted 2 December 2009. published online 15 January 2010.

Abstract 

Objective

This study acquired fluorine-18-deoxyglucose (FDG) kinetic parameters prior and subsequent to cisplatin chemotherapy so as to define the optimal parameters for early prediction of chemotherapy response.

Methods

A total of 12 non-tumor-bearing rabbits were used to obtain noninvasive input function, five VX2 tumor-bearing rabbits were used for validation and 32 tumor-bearing rabbits underwent 4 mg kg−1 cisplatin chemotherapy. Dynamic FDG PET/CT was performed at pretherapy, Day 0, Day 1, Day 7 and Day 14 after cisplatin administration. With the application of a three-compartment model, influx index (Ki), k1, k2, k3 and k4 were noninvasively obtained.

Results

Sensitive (SG) and insensitive groups (ISG) were defined based on their volume on Day 7. k1, Ki, SUVmean, and SUVmax showed significant decreases in SG vs. ISG at Day 0 (P<.076–0.0001). k1 demonstrated sustained (up to Day 7) differences (P<.028–0.0072), and k2, k3 and k4 showed no significant differences at any time point (P>.05). Soon after cisplatin administration, GLUT-1 expression was greatly decreased in SG vs. ISG.

Conclusions

The parameters of SUVmax, SUVmean, Ki and k1 were valuable for the early prediction of chemotherapy response. k1 had a wider observation window compared to SUVmean, SUVmax and Ki, and k1 also reflected the changes in GLUT-1 expression.

Keywords: 18F-FDG PET/CT, Cisplatin, Chemotherapy, VX2 tumors, FDG kinetic modeling

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☆ There are no potential conflicts of interest to disclose.

☆☆ This work was supported by National Natural Science Foundation of China (no.30830038) and the Shanghai Leading Academic Discipline Project (project no. S30203), Shanghai Science and Technology Commission's international cooperation project fund (nos. 08410702000 and 07JC14039, and grant nos. PY07002, 09XJ21032, YG08PETMS08 and SS08031).

PII: S0969-8051(09)00292-3

doi:10.1016/j.nucmedbio.2009.12.002

Nuclear Medicine and Biology
Volume 37, Issue 3 , Pages 327-333, April 2010

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