Nuclear Medicine and Biology
Volume 37, Issue 2 , Pages 149-155 , February 2010

Formulation of 68Ga BAPEN kit for myocardial positron emission tomography imaging and biodistribution study

  • Bo Yeun Yang

      Affiliations

    • Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, 110-744 Seoul, South Korea
    • Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-744, South Korea
    • Department of Radiation Applied Life Science, Seoul National University College of Medicine, Seoul 110-744, South Korea
  • ,
  • Jae Min Jeong

      Affiliations

    • Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, 110-744 Seoul, South Korea
    • Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-744, South Korea
    • Department of Radiation Applied Life Science, Seoul National University College of Medicine, Seoul 110-744, South Korea
    • Corresponding Author InformationCorresponding author. Department of Nuclear Medicine, Seoul National University Hospital, Seoul 110-744, South Korea. Tel.: +82 2 2072 3805; fax: +82 2 745 7690.
  • ,
  • Young Joo Kim

      Affiliations

    • Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, 110-744 Seoul, South Korea
    • Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-744, South Korea
  • ,
  • Jae Yeon Choi

      Affiliations

    • Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, 110-744 Seoul, South Korea
    • Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-744, South Korea
    • Department of Radiation Applied Life Science, Seoul National University College of Medicine, Seoul 110-744, South Korea
  • ,
  • Yun-Sang Lee

      Affiliations

    • Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, 110-744 Seoul, South Korea
  • ,
  • Dong Soo Lee

      Affiliations

    • Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, 110-744 Seoul, South Korea
    • Department of Radiation Applied Life Science, Seoul National University College of Medicine, Seoul 110-744, South Korea
  • ,
  • June-Key Chung

      Affiliations

    • Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, 110-744 Seoul, South Korea
    • Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-744, South Korea
    • Department of Radiation Applied Life Science, Seoul National University College of Medicine, Seoul 110-744, South Korea
  • ,
  • Myung Chul Lee

      Affiliations

    • Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, 110-744 Seoul, South Korea
    • Department of Radiation Applied Life Science, Seoul National University College of Medicine, Seoul 110-744, South Korea

Received 7 May 2009 ,Revised 7 October 2009 ,Accepted 23 October 2009.

References 

  1. Cagnolini A, Whitener D, Jurisson S. Comparison of the kit performance of three 99mTc myocardial perfusion agents. Nucl Med Biol. 1998;25:435–439
  2. Gerson M, Deutsch E, Nishiyama H, Libson K, Adolph R, Grossman L. Myocardial perfusion imaging with 99mTc-DMPE in man. Eur J Nucl Med. 1983;8:371–374
  3. Higley B, Smith FW, Smith T, Gemmell HG, Gupta PD, Gvozdanovic DV, et al. Technetium-99m-1,2-bis[bis(2-ethoxyethyl)phosphino)ethane: human biodistribution, dosimetry and safety of a new myocardial perfusion imaging agent. J Nucl Med. 1993;34:30–38
  4. Jeong JM, Lee Y-S, Kim YJ, Lee DS, Chung J-K, Suh Y-G, et al. Cationic complex: 99mTc-N,N′-dimethyldiaminedithiol. Nucl Med Biol. 2002;29:711–717
  5. Paeng JC, Lim I, Kim KB, Lee DS. Consideration of normal variation of perfusion measurements in the quantitative analysis of myocardial perfusion SPECT: usefulness in assessment of viable myocardium. Nucl Med Mol Imaging. 2008;42:285–291
  6. Kitsiou AN, Bacharach SL, Bartless ML, Srinivasan G, Summers RM, Quyyumi AA, et al. 13N-ammonia myocardial blood flow and uptake. J Am Coll Cardiol. 1999;33:678–686
  7. Kong E-J, Cho I-H, Chun K-A, Won K-C, Lee H-W, Park J-S, et al. Comparison of clinical usefulness between N-13 ammonia PET/CT and Tc-99m sestamibi SPECT in coronary artery disease. Nucl Med Mol Imaging. 2008;42:354–361
  8. Asti M, Pietri GD, Fraternali A, Grassi E, Sghedoni R, Fioroni F, et al. Validation of 68Ge/68Ga generator processing by chemical purification for routine clinical application of 68Ga-DOTATOC. Nucl Med Biol. 2008;35:721–724
  9. Azhdarinia A, Yang DJ, Chao C, Mourtada F. Infrared-based module for the synthesis of 68Ga-labeled radiotracers. Nuclear Medicine and Biology. 2007;34:121–127
  10. Jeong JM, Kim YJ, Lee Y-S, Lee DS, Chung J-K, Lee MC. Radiolabeling of NOTA and DOTA with positron emitting 68Ga and investigation of in vitro properties. Nucl Med Mol Imaging. 2009;43:330–336
  11. McElvany KD, Hopkins KT, Welch MJ. Comparison of 68Ge/68Ga generator systems for radiopharmaceutical production. Int J Appl Radiat Isot. 1984;35:521–524
  12. Nakayama M, Haratake M, Koiso T, Ishibashi O, Harada K, Nakayama H, et al. Separation of 68Ga from 68Ge using a macroporous organic polymer containing N-methylglucamine groups. Anal Chim Acta. 2002;453:135–141
  13. Green MA, Mathias CJ, Neumann WL, Fanwick PE, Janik M, Deutsch EA. Potential gallium-68 tracers for imaging the heart with PET: evaluation of four gallium complexes with functionalized tripodal tris(salicylaldimine) ligands. J Nucl Med. 1993;34:228–233
  14. Green MA, Welch MJ, Huffman JC. Synthesis and crystallographic characterization of a gallium salicylaldimine complex of radiopharmaceutical interest. J Am Chem Soc. 1984;106:3689–3691
  15. Green MA, Welch MJ, Mathias CJ, Fox KAA, Knabb RM, Huffman JC. Gallium-68 1,1,1-tris(5-methoxysalicyaldiminomethyl)ethane: a potential tracer for evaluation of regional myocardial blood flow. J Nucl Med. 1985;26:170–180
  16. Kung HF, Liu BL, Mankoff D, Kung MP, Billings JJ, Francesconi L, et al. A new myocardial imaging agent: synthesis, characterization, and biodistribution of gallium-68-BAT-TECH. J Nucl Med. 1990;31:1635–1640
  17. Plossl K, Chandra R, Qu W, lieberman BP, Kung M-P, Zhou R, et al. A novel gallium bisaminothiolate complex as a myocardial perfusion imaging agent. Nucl Med Biol. 2008;35:83–90
  18. Tsang BW, Mathias CJ, Fanwick PE, Green MA. Structure-distribution relationships for metal-labeled myocardial imaging agents: comparison of a series cationic gallium(III) complexes with hexadentate bis(salicylaldimine) ligands. J Med Chem. 1994;37:4400–4406
  19. Tsang BW, Mathias CJ, Green MA. A gallium-68 radiopharmaceutical that is retained in myocardium: 68Ga[(4,6-MeO2sal)2BAPEN]+. J Nucl Med. 1993;34:1127–1131
  20. Eckelman WC, Richards P, Hauser W, Atkins HL. 99mTc-DTPA preparations. J Nucl Med. 1971;12:699
  21. Geoffrey A, Scott M. Determination of product shelf life and activation energy for five drugs of abuse. Clin Chem. 1991;37:398–402
  22. In: Expiration dating and stability testing for human drug products. U.S. Food and Drug Administration; 1985;p. 41
  23. Magari RT, Murphy KP, Fernandex T. Accelerated stability model for predicting shelf-life. J Clin Lab Anal. 2002;16:221–226
  24. Hsiao Y-M, Mathias CJ, Wey SP, Fanwick PE, Green MA. Synthesis and biodistribution of lipophilic and monocationic gallium radiopharmaceuticals derived from N,N′-bis(3-aminopropyl)-N,N′-dimethylethylenediamine: potential agents for PET myocardial imaging with 68Ga. Nucl Med Biol. 2009;36:39–45
  25. Kulprathipanja S, Hnatowich D. A method for determining the pH stability range of gallium radiopharmaceuticals. Int J Appl Radiat Isot. 1977;28:229–233
  26. Kulprathipanja S, Hnatowich D, Evans G. The effect of pH on the in vitro and in vivo behavior of complex-free 68Ga and 113Inm. Nucl Med Biol. 1978;5:140–144
  27. Carvalho PA, Chiu ML, Kronauge JF, Kawamura M, Jones AG, Holman BL, et al. Subcellular distribution and analysis of technetium-99m-MIBI in isolated perfused rat hearts. J Nucl Med. 1992;33:1516–1522
  28. Crane P, Laliberte R, Heminway S, Thoolen M, Orlandi C. Effect of mitochondrial viability and metabolism on technetium-99m-sestamibi myocardial retention. Eur J Nucl Med Mol Imaging. 1992;20:20–25
  29. Wang J, Yang C-T, Kim Y-S, Sreerama SG, Cao Q, Li Z-B, et al. 64Cu-labeled triphenylphosphonium and triphenylarsonium cations as highly tumor-selective imaging agents. J Med Chem. 2007;50:5057–5069

PII: S0969-8051(09)00258-3

doi: 10.1016/j.nucmedbio.2009.10.010

Nuclear Medicine and Biology
Volume 37, Issue 2 , Pages 149-155 , February 2010