Nuclear Medicine and Biology
Volume 37, Issue 2 , Pages 189-196 , February 2010

Stimulation of 125I-3-iodo-α-methyl-l-tyrosine uptake in Chinese hamster ovary (CHO-K1) cells by tyrosine esters

  • Naoto Shikano

      Affiliations

    • Department of Radiological Sciences, Center for Medical Sciences and Center for Humanities and Sciences, Ibaraki Prefectural University of Health Sciences, Inashiki-gun, Ibaraki, Japan
    • Corresponding Author InformationCorresponding author. Department of Radiological Sciences, Ibaraki Prefectural University of Health Sciences, Inashiki-gun, Ibaraki 300-0394, Japan. Tel.: +81 298 40 2217; fax: +81 298 40 2317.
    • Current address: Division of Health Science, Graduate School of Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa 9200-942, Japan.
    • ,
  • Masato Ogura

      Affiliations

    • Department of Radiological Sciences, Center for Medical Sciences and Center for Humanities and Sciences, Ibaraki Prefectural University of Health Sciences, Inashiki-gun, Ibaraki, Japan
    • ,
  • Jun-ichi Sagara

      Affiliations

    • Department of Radiological Sciences, Center for Medical Sciences and Center for Humanities and Sciences, Ibaraki Prefectural University of Health Sciences, Inashiki-gun, Ibaraki, Japan
    • ,
  • Syuichi Nakajima

      Affiliations

    • Department of Radiological Sciences, Center for Medical Sciences and Center for Humanities and Sciences, Ibaraki Prefectural University of Health Sciences, Inashiki-gun, Ibaraki, Japan
    • ,
  • Masato Kobayashi

      Affiliations

    • Division of Health Science, Graduate School of Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan
    • ,
  • Takeshi Baba

      Affiliations

    • Department of Radiological Sciences, Center for Medical Sciences and Center for Humanities and Sciences, Ibaraki Prefectural University of Health Sciences, Inashiki-gun, Ibaraki, Japan
    • ,
  • Naoto Yamaguchi

      Affiliations

    • Department of Radiological Sciences, Center for Medical Sciences and Center for Humanities and Sciences, Ibaraki Prefectural University of Health Sciences, Inashiki-gun, Ibaraki, Japan
    • ,
  • Yukio Iwamura

      Affiliations

    • Department of Radiological Sciences, Center for Medical Sciences and Center for Humanities and Sciences, Ibaraki Prefectural University of Health Sciences, Inashiki-gun, Ibaraki, Japan
    • ,
  • Nobuo Kubota

      Affiliations

    • Department of Radiological Sciences, Center for Medical Sciences and Center for Humanities and Sciences, Ibaraki Prefectural University of Health Sciences, Inashiki-gun, Ibaraki, Japan
    • ,
  • Keiichi Kawai

      Affiliations

    • Division of Health Science, Graduate School of Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan

Received 24 March 2009 ,Revised 17 September 2009 ,Accepted 2 October 2009.

References 

  1. Biersack HJ, Coenen HH, Stoecklin G, Reichmann K, Bockische A, Oehr P, et al. Imaging of brain tumors with l-3-[I-123]iodo-α-methyl tyrosine and SPECT. J Nucl Med. 1989;30:110–112
  2. Kuwert T, Woesler B, Morgenroth C, Lerch H, Schafers M, Palkovic S, et al. Diagnosis of recurrent glioma with SPECT and iodine-123-α-methyl tyrosine. J Nucl Med. 1998;39:23–27
  3. Jager PL, Franssen EJF, Kool W, Szabo BG, Hoeckstra HJ, Groen HJM, et al. Feasibility of tumor imaging using l-3-[iodine-123]-iodo-alpha-methyl-tyrosine in extracranial tumors. J Nucl Med. 1998;39:1736–1743
  4. Langen KJ, Pauleit D, Coenen HH. 3-[123I]Iodo-α-methyl-l-tyrosine: uptake mechanisms and clinical applications. Nucl Med Biol. 2002;29:625–631
  5. Langen KJ, Muhlensiepen H, Holschibach M, Hautzel H, Jansen P, Coenen HH. Transport mechanisms of 3-[123I]iodo-α-methyl-l-tyrosine in a human glioma cell line: comparison with [3H-methyl]-l-methionine. J Nucl Med. 2004;41:1250–1255
  6. Kawai K, Fujibayashi Y, Saji H, Yonekura Y, Konishi J, Kubodera A, et al. A strategy for study of cerebral amino acid transport using iodine-123-labeled amino acid radiopharmaceutical: 3-iodo-alpha-methyl-l-tyrosine. J Nucl Med. 1991;32:819–824
  7. Kawai K, Fujibayashi Y, Yonekura Y, Konishi J, Saji H, Kubodera A, et al. An artificial amino acid radiopharmaceutical for single photon emission computed tomographic study of pancreatic amino acid transports 123I-3-iodo-alpha-methyl-l-tyrosine. Ann Nucl Med. 1992;6:169–175
  8. Kawai K, Fujibayashi Y, Yonekura Y, Tanaka K, Saji H, Konishi J, et al. Canine SPECT studies for cerebral amino acid transport by means of 123I-3-iodo-α-methyl-l-tyrosine and preliminary kinetic analysis. Ann Nucl Med. 1995;9:47–50
  9. Christensen HN. Role of amino acid transport and counter-transport in nutrition and metabolism. Physiol Rev. 1990;70:43–77
  10. Palacin M, Kanai Y. The ancillary proteins of HATs: SLC3 family of amino acid transporters. Pflugers Arch. 2004;447:490–494
  11. Kanai Y, Hediger MA. The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects. Pflugers Arch. 2004;447:469–479
  12. Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y. CATs and HATs: the SLC7 family of amino acid transporters. Pflugers Arch. 2004;447:532–542
  13. Weissbach L, Handlogten ME, Christensen HN, Kilberg MS. Evidence of two Na-independent neutral amino acid transport systems in primary cultures of rat hepatocytes. J Biol Chem. 1982;256:12006–12011
  14. Kanai Y, Segawa H, Miyamoto K, Uchino H, Takeda E, Endou H. Expression cloning and characterization of a transporter for large neutral amino acids activated by heavy chain of 4F2 antigen (CD98). J Biol Chem. 1998;273:23629–23632
  15. Yanagida O, Kanai Y, Chairoungdua A, Kim DK, Segawa H, Nii T. Human l-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. Biochim Biophys Acta. 2001;1514:291–302
  16. Reimann B, Stoegbauer F, Kopka K, Halffer H, Lasic M, Schirmachr A, et al. Kinetics of 3-[123I]iodo-l-α-methyl tyrosine transport in rat C6 glioma cells. Eur J Nucl Med. 1999;26:1274–1278
  17. Riemann B, Kopka K, Stogbauer F, Halfter H, Ketterler S, Vu Phan TQ, et al. Kinetic parameters of 3-[123I]iodo-l-α-methyl tyrosine ([123I]IMT) transport in human GOS3 glioma cells. Nucl Med Biol. 2001;28:293–297
  18. Franzius C, Kopka K, Valen F, Eckervogt V, Riemann B, Sciuk J. Characterization of 3-[123I]iodo-l-α-methyl tyrosine transport ([123I]IMT) transport into human Ewing's sarcoma cells in vitro. Nucl Med Biol. 2001;28:123–128
  19. Lahoutte T, Caveliers V, Dierickx L, Vekeman M, Everaert H, Mertens J, et al. In vitro characterization of the influx of 3-[125I]iodo-l-α-methyl tyrosine and 2-[125I]iodo-l-tyrosine into U266 human myeloma cells: evidence for system T transport. Nucl Med Biol. 2001;28:129–134
  20. Prante O, Deichen JT, Hocke C, Kuwert T. Characterization of uptake of 3-[131I]iodo-alpha-methyl-l-tyrosine in human monocyte-macrophages. Nucl Med Biol. 2004;3:365–372
  21. Shotwell MA, Jayme DW, Kilberg MS, Oxender DL. Neutral amino acid transport systems in Chinese hamster ovary cells. J Biol Chem. 1981;256:5422–5427
  22. Hayer M, Bonisch H, Bruss M. Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1). Ann Hum Genet. 1999;63:473–482
  23. Fukumoto M, Kurohara A, Yoshimura N, Yoshida D, Akagi N, Yoshida S. Relationship between ATP synthesis and 201Tl uptake in transformed and non-transformed cell lines. Nucl Med Commun. 1998;19:1169–1175
  24. Trinchieri G, De Marchi M. Antibody-dependent cell-mediated cytotoxicity in humans. II. Energy requirement. J Immunol. 1975;115:256–260
  25. Shikano N, Kawai K, Nakajima S, Nishii R, Flores LG, Kubodera A, et al. Renal accumulation and excretion of radioiodinated 3-iodo-α-methyl-l-tyrosine. Ann Nucl Med. 2004;18:225–232
  26. Sagara J, Sugita Y. Characterization of cytosolic glutathione S-transferase in cultured astrocytes. Brain Res. 2002;902:190–197
  27. Kobayashi K, Ohnishi A, Promsuk J, Shimizu S, Kanai Y, Shiokawa Y, et al. Enhanced tumor growth elicited by l-type amino acid transporter 1 in human malignant glioma cells. Neurosurgery. 2008;62:493–503
  28. Kondoh N, Imazeki N, Arai M, Hada A, Hatsuse K, Matsuo H, et al. Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues. Int J Oncol. 2007;31:81–87
  29. Shikano N, Kanai Y, Kawai K, Ishikawa N, Endou H. Characterization of 3-[125I]iodo-α-methyl-l-tyrosine transport via human l-type amino acid transporter 1. Nucl Med Biol. 2003;30:31–37
  30. Shikano N, Kanai Y, Kawai K, Inatomi J, Kim do K, Ishikawa N, et al. Isoform selectivity of 3-125I-iodo-alpha-methyl-l-tyrosine membrane transport in human l-type amino acid transporters. J Nucl Med. 2003;44:244–246
  31. Eriksson B, Bergstrom M, Orlefors H, Sundin A, Langstrom B. Use of PET in neuroendocrine tumors: in vivo applications and in vitro studies. Q J Nucl Med. 2000;44:68–76
  32. Lahoutte T, Caveliers V, Franken PR, Bossuyt A, Mertens J, Everaert H. Increased tumor uptake of 3-123I-iodo-l-alpha-methyltyrosine after preloading with amino acids: an in vivo animal imaging study. J Nucl Med. 2002;43:1201–1206
  33. Nakajima S, Shikano N, Kotani T, Ogura M, Nishii R, Yoshimoto M, et al. Pharmacokinetics of 3-[125I]iodo-α-methyl-l-tyrosine, a tumor imaging agent, after probenecid loading in mice implanted with colon cancer DLD-1 cells. Nucl Med Biol. 2007;34:1003–1008

PII: S0969-8051(09)00243-1

doi: 10.1016/j.nucmedbio.2009.10.003

Nuclear Medicine and Biology
Volume 37, Issue 2 , Pages 189-196 , February 2010

Article Tools

* Image Usage & Resolution