« Previous
Next »
Nuclear Medicine and Biology
Volume 37, Issue 2
, Pages 117-123
, February 2010
Preliminary studies of 99mTc-BnAO and its analogues: synthesis, radiolabeling and in vitro cell uptake
References
- . Tumour hypoxia: the picture has changed in the 1990s. Int J Radiat Biol. 1994;65:95–102
- . The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol. 1953;26:638–648
- . Hypoxia in head and neck cancer: how much, how important?. Head Neck. 2005;27:622–638
- Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: a pretherapy study of 37 patients. Int J Radiat Oncol Biol Phys. 1996;36:417–428
- Improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin. N Engl J Med. 1997;337:295–300
- . An insight into tumoral hypoxia: the radiomarkers and clinical applications. Oncol Rev. 2009;3:3
- . Imaging and cancer: a review. Mol Oncol. 2008;2:115–152
- . Nuclear medicine's double hazard. Nonprolif Rev. 2008;15:185–208
- . Unparalleled contribution of technetium-99m to medicine over 5 decades. JACC Cardiovasc Imaging. 2009;2:364–368
- . The development of 99mTc-analog of Cu-DTS as an agent for imaging hypoxia. Nucl Med Biol. 2000;27:391–399
- . Technetium-99m-labeled HL91 to identify tumor hypoxia: correlation with fluorine-18-FDG. J Nucl Med. 1998;39:99–103
- . 99mTc-HL91. Effects of low flow and hypoxia on a new ischemia-avid myocardial imaging agent. Circulation. 1997;95:1892–1899
- . Studies of 99mTc-BnAO (HL-91): a non-nitroaromatic compound for hypoxic cell detection. Int J Radiat Oncol, Biol, Phys. 1998;42:737–740
- Preclinical evaluation of the novel hypoxic marker 99mTc-HL91 (Prognox) in murine and xenograft systems in vivo. Int J Radiat Oncol Biol Phys. 1998;42:731–735
- . Towards new transition metal-based hypoxic selective agents for therapy and imaging. J Inorg Biochem. 2001;85:15–22
- . The chemical characterization of the tumour imaging agent 99mTc-HL91. Eur J Nucl Med. 1997;24:943
- . Measuring hypoxia and predicting tumor radioresistance with nuclear medicine assays. Radiother Oncol. 1998;46:229–237
- . The interconversion mechanism between TcO3+ and TcO2+ core of 99mTc labeled amine-oxime (AO) complexes. Theor Chem Acc. 2008;121:271–278
- . Cellular accumulation and retention of the technetium-99m-labelled hypoxia markers BRU59-21 and butylene amine oxime. Nucl Med Biol. 2001;28:949–957
- . Preparation and biological characterization of novel HL91-derivative analog for hypoxic tumor imaging. Eur J Nucl Med Mol Imaging. 2007;34:S202
- . Copper anti-inflammatory drugs in rheumatoid arthritis: Part 4. A potentiometric and spectroscopic study of copper(II) diaminodioxime complexes. J Chem Soc, Dalton Trans. 1996;1373–1377
- . Synthesis of functionalized 3,3,9,9-tetramethyl-4,8-diazaundecane-2,10-dione dioximes (propylene amine oximes, PnAOs). Synth Commun. 1995;25:743–752
- . The correlation of serum protein association and cellular uptake with lipophilicity and polarity of the backbone substituents of the technetium-99m-amine-oxime chelates. J Labelled Compd Radiopharm. 2007;50:91–95
- . Design of hypoxia-targeting radiopharmaceuticals: selective uptake of copper-64 complexes in hypoxic cells in vitro. Eur J Nucl Med. 1998;25:788–792
- . Novel amine-dioxime chelator for technetium-99m: synthesis and evaluation of 2-nitroimidazole-containing analogues as markers for hypoxic cells. Bioconjugate Chem. 2000;11:652–663
- . Targeting hypoxia in tumors using 2-nitroimidazoles with peptidic chelators for technetium-99m: effect of lipophilicity. Bioconjugate Chem. 2000;11:401–407
PII: S0969-8051(09)00241-8
doi: 10.1016/j.nucmedbio.2009.09.003
© 2010 Elsevier Inc. All rights reserved.
« Previous
Next »
Nuclear Medicine and Biology
Volume 37, Issue 2
, Pages 117-123
, February 2010
