Nuclear Medicine and Biology
Volume 37, Issue 1 , Pages 29-34 , January 2010

Apoptotic abscess imaging with 99mTc-HYNIC-rh-Annexin-V

Received 13 July 2009 ,Revised 11 August 2009 ,Accepted 25 August 2009.

References 

  1. Akgul C, Moulding DA, Edwards SW. Molecular control of neutrophil apoptosis. FEBS Lett. 2001;487:318–322
  2. Luo HR, Loison F. Constitutive neutrophil apoptosis: mechanisms and regulation. Am J Hematol. 2008;83:288–295
  3. Salamone G, Giordano M, Trevani AS, Gamberale R, Vermeulen M, Schettinni J, et al. Promotion of neutrophil apoptosis by TNF-alpha. J Immunol. 2001;166:3476–3483
  4. Scheel-Toellner D, Wang KQ, Webb PR, Wong SH, Craddock R, Assi LK, et al. Early events in spontaneous neutrophil apoptosis. Biochem Soc Trans. 2004;32:461–464
  5. Lauber K, Blumenthal SG, Waibel M, Wesselborg S. Clearance of apoptotic cells: getting rid of the corpses. Mol Cell. 2004;14:277–287
  6. Liu G, Wang J, Park YJ, Tsuruta Y, Lorne EF, Zhao X, et al. High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine. J Immunol. 2008;181:4240–4246
  7. Bratton DL, Fadok VA, Richter DA, Kailey JM, Guthrie LA, Henson PM. Appearance of phosphatidylserine on apoptotic cells requires calcium-mediated nonspecific flip-flop and is enhanced by loss of the aminophospholipid translocase. J Biol Chem. 1997;272:26159–26165
  8. Fadeel B, Ahlin A, Henter JI, Orrenius S, Hampton MB. Involvement of caspases in neutrophil apoptosis: regulation by reactive oxygen species. Blood. 1998;92:4808–4818
  9. Kagan VE, Fabisiak JP, Shvedova AA, Tyurina YY, Tyurin VA, Schor NF, et al. Oxidative signaling pathway for externalization of plasma membrane phosphatidylserine during apoptosis. FEBS Lett. 2000;477:1–7
  10. Tokita N, Hasegawa S, Maruyama K, Izumi T, Blankenberg FG, Tait JF, et al. 99mTc-Hynic-annexin V imaging to evaluate inflammation and apoptosis in rats with autoimmune myocarditis. Eur J Nucl Med Mol Imaging. 2003;30:232–238
  11. Blankenberg FG, Kalinyak J, Liu L, Koike M, Cheng D, Goris ML, et al. 99mTc-HYNIC-annexin V SPECT imaging of acute stroke and its response to neuroprotective therapy with anti-Fas ligand antibody. Eur J Nucl Med Mol Imaging. 2006;33:566–574
  12. Rao PS, Pallela VR, Vassileva-Belnikolovska D, Jungkind D, Thakur ML. A receptor-specific peptide for imaging infection and inflammation. Nucl Med Commun. 2000;21:1063–1070
  13. Brewer S, McPherson M, Fujiwara D, Turovskaya O, Ziring D, Chen L, et al. Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro-d-glucose and positron emission tomography. Gastroenterology. 2008;135:744–755
  14. Harari OA, Al-Nahhas A, Jawad A. 18F-Fluorodeoxyglucose-positron emission tomography imaging in idiopathic inflammatory myositis. Nucl Med Commun. 2008;29:838–840
  15. Bleeker-Rovers CP, Rennen HJ, Boerman OC, Wymenga AB, Visser EP, Bakker JH, et al. 99mTc-labeled interleukin 8 for the scintigraphic detection of infection and inflammation: first clinical evaluation. [See comment]. J Nucl Med. 2007;48:337–343
  16. Cao Q, Cai W, Li ZB, Chen K, He L, Li HC, et al. PET imaging of acute and chronic inflammation in living mice. Eur J Nucl Med Mol Imaging. 2007;34:1832–1842
  17. Fanning NF, Manning BJ, Buckley J, Redmond HP. Iodinated contrast media induce neutrophil apoptosis through a mitochondrial and caspase mediated pathway. Br J Radiol. 2002;75:861–873
  18. Lorberboym M, Feldbrin Z, Hendel D, Blankenberg FG, Schachter P. The use of 99mTc-recombinant human annexin V imaging for differential diagnosis of aseptic loosening and low-grade infection in hip and knee prostheses. J Nucl Med. 2009;50:534–537
  19. Penn DL, Zhang K, Mukherjee A, Devadhas D, Thakur ML. Apoptotic abscess imaging with 99m-Tc-HYNIC-Annexin V. J Nucl Med. 2009;50:261P
  20. Goldsmith SJ, Vallabhajosula S. Clinically proven radiopharmaceuticals for infection imaging: mechanisms and applications. Semin Nucl Med. 2009;39:2–10
  21. Palestro CJ. Radionuclide imaging of infection: in search of the grail. J Nucl Med. 2009;50:671–673
  22. Kemerink GJ, Liu X, Kieffer D, Ceyssens S, Mortelmans L, Verbruggen AM, et al. Safety, biodistribution, and dosimetry of 99mTc-HYNIC-annexin V, a novel human recombinant annexin V for human application. J Nucl Med. 2003;44:947–952
  23. Lu YQ, Huang WD, Cai XJ, Gu LH, Mou HZ. Hypertonic saline resuscitation reduces apoptosis of intestinal mucosa in a rat model of hemorrhagic shock. J Zhejiang Univ Sci B. 2008;9:879–884
  24. Qiu J, Gao CL, Zhang M, Chen RH, Chi X, Liu F, et al. LYRM1, a novel gene promotes proliferation and inhibits apoptosis of preadipocytes. Eur J Endocrinol. 2009;160:177–184
  25. Sarda-Mantel L, Hervatin F, Michel JB, Louedec L, Martet G, Rouzet F, et al. Myocardial uptake of 99mTc-annexin-V and 111In-antimyosin-antibodies after ischemia-reperfusion in rats. Eur J Nucl Med Mol Imaging. 2008;35:158–165

PII: S0969-8051(09)00223-6

doi: 10.1016/j.nucmedbio.2009.08.011

Nuclear Medicine and Biology
Volume 37, Issue 1 , Pages 29-34 , January 2010