Nuclear Medicine and Biology
Volume 37, Issue 1 , Pages 17-20, January 2010

A simple and rapid technique for recovery of 99mTc from low specific activity (n,γ)99Mo based on solid–liquid extraction and column chromatography methodologies☆

Radiopharmaceuticals Laboratory, Board of Radiation and Isotope Technology (BRIT), Variable Energy Cyclotron Centre (VECC), 1/AF, Bidhan Nagar, Kolkata, 700 064, India

Received 25 June 2009; received in revised form 3 August 2009; accepted 28 August 2009. published online 05 October 2009.

Abstract 

A simple and inexpensive method has been developed for the separation of 99mTc from 99Mo produced from the neutron activation of 98Mo by 98Mo(n,γ)99Mo nuclear reaction. The recovery of 99mTc was performed by solid–liquid extraction based on alumina column chromatography. The overall radiochemical yield for the complete separation of 99mTc was 85–97% (n=5). The separated Na[99mTc]TcO4 was of high radionuclidic, radiochemical and chemical purities. The method can be adopted for routine processing and use of 99mTc in radiopharmacy operations.

Keywords: (n,γ)99Mo, 99mTc/99Mo solid–liquid extraction generator, Methyl ethyl ketone, Purification, Alumina column chromatography, Na[99mTc]TcO4

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☆ Presented in part at the 9th Biennial Symposium on Nuclear and Radiochemistry (NUCAR-2009) at Mithibai College, Vile Parle, Mumbai, India, during January 7–10, 2009, and also presented in part at the 56th Annual Meeting, Society of Nuclear Medicine ( SNM) , Toronto, Ontario, Canada, June 13–17, 2009.

PII: S0969-8051(09)00220-0

doi:10.1016/j.nucmedbio.2009.08.009

Nuclear Medicine and Biology
Volume 37, Issue 1 , Pages 17-20, January 2010

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