Nuclear Medicine and Biology
Volume 37, Issue 1 , Pages 51-55, January 2010

Influence of chemoresistance and p53 status on fluoro-2-deoxy-d-glucose incorporation in cancer

School of Medical Sciences (Biomedical Physics), University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK

Received 19 August 2009; received in revised form 26 August 2009; accepted 27 August 2009. published online 05 October 2009.

Abstract 

Both mutant p53 and chemoresistance are poor prognostic factors in cancer. Many studies have examined the influence of these factors on fluoro-2-deoxy-d-glucose (FDG) incorporation. Whilst mutant p53 is associated with increased FDG incorporation, chemoresistance, especially when associated with P-glycoprotein, is associated with decreased FDG incorporation.

Keywords: Fluoro-2-deoxy-d-glucose, Chemoresistance, PET, p53

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PII: S0969-8051(09)00217-0

doi:10.1016/j.nucmedbio.2009.08.007

Nuclear Medicine and Biology
Volume 37, Issue 1 , Pages 51-55, January 2010

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