Nuclear Medicine and Biology
Volume 37, Issue 1 , Pages 67-72 , January 2010

Ultrafast LC method for purification and metabolite analysis of PET probes

  • Ryuji Nakao

      Affiliations

    • Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263-8555, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 43 206 4680; fax: +81 43 206 3261.
    • ,
  • Takehito Ito

      Affiliations

    • Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263-8555, Japan
    • Sumitomo Accelerator Service, Tokyo 141-8686, Japan
    • ,
  • Kazutaka Hayashi

      Affiliations

    • Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263-8555, Japan
    • ,
  • Toshimitsu Fukumura

      Affiliations

    • Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263-8555, Japan
    • ,
  • Kazutoshi Suzuki

      Affiliations

    • Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263-8555, Japan

Received 8 July 2009 ,Revised 5 August 2009 ,Accepted 8 August 2009.

References 

  1. Allard M, Fouquet E, James D, Szlosek-Pinaud M. State of art in 11C labelled radiotracers synthesis. Curr Med Chem. 2008;15:235–277
  2. Miller PW, Long NJ, Vilar R, Gee AD. Synthesis of 11C, 18F, 15O, and 13N radiolabels for positron emission tomography. Angew Chem Int Ed Engl. 2008;47:8998–9033
  3. Arkadij ME. Microreactors for radiopharmaceutical synthesis.. Lab Chip. 2009;9:1326–1333
  4. MacNair JE, Lewis KC, Jorgenson JW. Ultrahigh-pressure reversed-phase liquid chromatography in packed capillary columns. Anal Chem. 1997;69:983–989
  5. Plumb RS, Granger JH, Stumpf CL, Johnson KA, Smith BW, Gaulitz S, et al. A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: application to age, gender and diurnal variation in normal/Zucker obese rats and black, white and nude mice. Analyst. 2005;130:844–849
  6. Dejaegher B, Heyden YV. Ruggedness and robustness testing. J Chromatogr A. 2007;1158:138–157
  7. Wilson ID, Plumb R, Granger J, Major H, Williams R, Lenz EM. HPLC-MS–based methods for the study of metabonomics. J Chromatogr B. 2005;817:67–76
  8. Amitani M, Zhang MR, Noguchi J, Kumata K, Ito T, Takai N, et al. Blood flow dependence of the intratumoral distribution of peripheral benzodiazepine receptor binding in intact mouse fibrosarcoma. Nucl Med Biol. 2006;33:971–975
  9. Zhang MR, Kumata K, Maeda J, Yanamoto K, Hatori A, Okada M, et al. 11C-AC-5216: a novel PET ligand for peripheral benzodiazepine receptors in the primate brain. J Nucl Med. 2007;48:1853–1861
  10. Fukumura T, Suzuki H, Mukai K, Zhang MR, Yoshida Y, Nemoto K, et al. Development of versatile synthesis equipment for multiple production of PET radiopharmaceuticals. J Labelled Compd Radiopharm. 2007;50:S202
  11. Takei M, Kida T, Suzuki K. Sensitive measurement of positron emitters eluted from HPLC. Appl Radiat Isot. 2001;55:229–234
  12. Nakao R, Okada M, Inoue O, Fukumura T, Suzuki K. Combining high-performance liquid chromatography-positron detection and on-line microdialysis for animal metabolism study of positron emission tomography probes. J Chromatogr A. 2008;1203:193–197
  13. Dolle F, Bottlaender M, Demphel S, Emond P, Fuseau C, Coulon C, et al. Highly efficient synthesis of [11C]PE2I, a selective radioligand for the quantification of the dopamine transporter using PET. J Labelled Compd Radiopharm. 2000;43:997–1004
  14. Wilson AA, Houle S. Radiosynthesis of carbon-11 labelled N-methyl-2-(arylthio)benzylamines: potential radiotracers for the serotonin reuptake receptor. J Labelled Compd Radiopharm. 1999;42:1277–1288
  15. Halldin C, Stone-Elander S, Farde L, Ehrin E, Fasth KJ, Långström B, et al. Preparation of 11C-labelled SCH 23390 for the in vivo study of dopamine D-1 receptors using positron emission tomography. Int J Appl Radiat Isot. 1986;37:1039–1043

PII: S0969-8051(09)00212-1

doi: 10.1016/j.nucmedbio.2009.08.002

Nuclear Medicine and Biology
Volume 37, Issue 1 , Pages 67-72 , January 2010

Article Tools

* Image Usage & Resolution