Nuclear Medicine and Biology
Volume 36, Issue 6 , Pages 651-658 , August 2009

Comparison of radiolabeled isatin analogs for imaging apoptosis with positron emission tomography

  • Delphine L. Chen

      Affiliations

    • Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA
    • Corresponding Author InformationCorresponding author. Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • ,
  • Dong Zhou

      Affiliations

    • Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA
  • ,
  • Wenhua Chu

      Affiliations

    • Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA
  • ,
  • Phillip E. Herrbrich

      Affiliations

    • Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA
  • ,
  • Lynne A. Jones

      Affiliations

    • Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA
  • ,
  • Justin M. Rothfuss

      Affiliations

    • Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA
  • ,
  • Jacquelyn T. Engle

      Affiliations

    • Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA
  • ,
  • Marco Geraci

      Affiliations

    • Faculty of Medical and Human Sciences, University of Manchester, Manchester, M27 4HA United Kingdom
  • ,
  • Michael J. Welch

      Affiliations

    • Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA
  • ,
  • Robert H. Mach

      Affiliations

    • Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA

Received 15 November 2008 ,Revised 2 March 2009 ,Accepted 16 March 2009.

References 

  1. Mach RH. Functional imaging of cellular death. In:  Schuster DP,  Blackwell TJ editor. Molecular Imaging of the Lungs. Boca Raton: Taylor and Francis Group; 2005;p. 327–348
  2. Yanga Q, Underwooda MJ, Hsina MK, Liub XC, He GW. Dysfunction of pulmonary vascular endothelium in chronic obstructive pulmonary disease: basic considerations for future drug development. Curr Drug Metab. 2008;9(7):661–667
  3. Aneja A, Tang WH, Bansilal S, Garcia MJ, Farkouh ME. Diabetic cardiomyopathy: insights into pathogenesis, diagnostic challenges, and therapeutic options. Am J Med. 2008;121(9):748–757
  4. Cook MC. B cell biology, apoptosis, and autoantibodies to phospholipids. Thromb Res. 2004;114(5-6):307–319
  5. Friedlander RM. Apoptosis and caspases in neurodegenerative diseases. N Engl J Med. 2003;348(14):1365–1375
  6. Reed JC. Apoptosis mechanisms: implications for cancer drug discovery. Oncology (Williston Park). 2004;18(13 Suppl 10):11–20
  7. Zeitlin BD, Zeitlin IJ, Nor JE. Expanding circle of inhibition: small-molecule inhibitors of Bcl-2 as anticancer cell and antiangiogenic agents. J Clin Oncol. 2008;26(25):4180–4188
  8. Green DR. Apoptotic pathways: ten minutes to dead. Cell. 2005;121(5):671–674
  9. Thornberry NA, Lazebnik Y. Caspases: enemies within. Science. 1998;281(5381):1312–1316
  10. Broker LE, Kruyt FA, Giaccone G. Cell death independent of caspases: a review. Clin Cancer Res. 2005;11(9):3155–3162
  11. Kitanaka C, Kuchino Y. Caspase-independent programmed cell death with necrotic morphology. Cell Death Differ. 1999;6(6):508–515
  12. Salvesen GS, Dixit VM. Caspases: intracellular signaling by proteolysis. Cell. 1997;91(4):443–446
  13. Vaux DL, Strasser A. The molecular biology of apoptosis. Proc Natl Acad Sci U S A. 1996;93(6):2239–2244
  14. Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol. 2007;35(4):495–516
  15. Chapman JG, Magee WP, Stukenbrok HA, Beckius GE, Milici AJ, Tracey WR. A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury. Eur J Pharmacol. 2002;456(1-3):59–68
  16. Lee D, Long SA, Adams JL, Chan G, Vaidya KS, Francis TA, et al. Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality. J Biol Chem. 2000;275(21):16007–16014
  17. Zhou D, Chu W, Rothfuss J, Zeng C, Xu J, Jones L, et al. Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis. Bioorg Med Chem Lett. 2006;16(19):5041–5046
  18. Faust A, Wagner S, Law MP, Hermann S, Schnockel U, Keul P, et al. The nonpeptidyl caspase binding radioligand (S)-1-(4-(2-[18F]fluoroethoxy)-benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin ([18F]CbR) as potential positron emission tomography-compatible apoptosis imaging agent. Q J Nucl Med Mol Imaging. 2007;51(1):67–73
  19. Zhou D, Chu W, Chen DL, Wang Q, Reichert DE, Rothfuss JM, et al [18F] and [11C]N-benzyl-isatin sulfonamide analogues as PET tracers for apoptosis: synthesis, radiolableing mechanism, and in vivo imaging study of apoptosis in Fas-treated mice using [11C]WC-98. Org Biomol Chem. 2009;7(7):1337–1348
  20. Faa G, Ledda-Columbano GM, Ambu R, Congiu T, Coni P, Riva A, et al. An electron microscopic study of apoptosis induced by cycloheximide in rat liver. Liver. 1994;14(5):270–278
  21. Ledda-Columbano GM, Coni P, Faa G, Manenti G, Columbano A. Rapid induction of apoptosis in rat liver by cycloheximide. Am J Pathol. 1992;140(3):545–549
  22. Kumar S. Measurement of caspase activity in cells undergoing apoptosis. In:  Brady HJM editors. Apoptosis Methods and Protocols. Totowa: Humana Press, Inc.; 2004;p. 19–30
  23. Holm S. A simple sequentially rejective Bonferroni test procedure. Scand Stat Theory Appl. 1979;6:65–70
  24. Blankenberg FG, Katsikis PD, Tait JF, Davis RE, Naumovski L, Ohtsuki K, et al. In vivo detection and imaging of phosphatidylserine expression during programmed cell death. Proc Natl Acad Sci U S A. 1998;95(11):6349–6354
  25. Yagle KJ, Eary JF, Tait JF, Grierson JR, Link JM, Lewellen B, et al. Evaluation of 18F-annexin V as a PET imaging agent in an animal model of apoptosis. J Nucl Med. 2005;46(4):658–666
  26. Zeng W, Yao ML, Townsend D, Kabalka G, Wall J, Le Puil M, et al. Synthesis, biological evaluation and radiochemical labeling of a dansylhydrazone derivative as a potential imaging agent for apoptosis. Bioorg Med Chem Lett. 2008;18(12):3573–3577

 This work was funded by NIH HL13851 and EB006702.

PII: S0969-8051(09)00085-7

doi: 10.1016/j.nucmedbio.2009.03.008

Nuclear Medicine and Biology
Volume 36, Issue 6 , Pages 651-658 , August 2009