Nuclear Medicine and Biology
Volume 36, Issue 5 , Pages 561-568 , July 2009

170Tm-EDTMP: a potential cost-effective alternative to 89SrCl2 for bone pain palliation

  • Tapas Das

      Affiliations

    • Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085, India
    • ,
  • Sudipta Chakraborty

      Affiliations

    • Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085, India
    • ,
  • Haladhar D. Sarma

      Affiliations

    • Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400085, India
    • ,
  • Pankaj Tandon

      Affiliations

    • Radiological Safety Division, Atomic Energy Regulatory Board, Mumbai 400094, India
    • ,
  • Sharmila Banerjee

      Affiliations

    • Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085, India
    • ,
  • Meera Venkatesh

      Affiliations

    • Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085, India
    • Corresponding Author InformationCorresponding author. Tel.: +91 22 2559 3676; fax: +91 22 2550 5151.
    • ,
  • Maroor R.A. Pillai

      Affiliations

    • Industrial Applications and Chemistry Section, International Atomic Energy Agency, A-1400 Vienna, Austria

Received 14 August 2008 ,Revised 15 January 2009 ,Accepted 18 February 2009.

References 

  1. Goeckler WF, Edwards B, Volkert WA, Holmes RA, Simon J, Wilson D. Skeletal localization of samarium-153 chelates: potential therapeutic bone agents. J Nucl Med. 1987;28:495–504
  2. Maini CL, Bergomi S, Romano L, Sciuoto R. 153Sm-EDTMP for bone pain palliation in skeletal metastasis. Eur J Nucl Med Mol Imaging. 2004;31(Suppl 1):S171–S178
  3. Trycross RG, Fairfield S. Pain in advanced cancer. Pain. 1982;14:303–310
  4. Pandit-Taskar N, Batraki M, Divgi CR. Radiopharmaceutical therapy for palliation of bone pain from osseous metastases. J Nucl Med. 2004;45:1358–1365
  5. Lewington VJ. Cancer therapy using bone-seeking isotopes. Phys Med Biol. 1996;41:2027–2042
  6. Hoskin PJ. Bisphosphonates and radiation therapy for palliation of metastatic bone disease. Cancer Treat Rev. 2003;29:321–327
  7. Lewington VJ. Bone-seeking radionuclides for therapy. J Nucl Med. 2005;46:38S–47S
  8. Volkert WA, Hoffman TJ. Therapeutic radiopharmaceuticals. Chem Rev. 1999;99:2269–2292
  9. Hosain F, Spencer RP. Radiopharmaceuticals for palliation of metastatic osseous lesions: biologic and physical background. Semin Nucl Med. 1992;22:11–16
  10. Atkins HL. Overview of nuclides for bone pain palliation. Appl Radiat Isot. 1998;49:277–283
  11. Ercan MT, Caglar M. Therapeutic radiopharmaceuticals. Curr Pharm Design. 2000;6:1085–1121
  12. Srivastava S, Dadachova E. Recent advances in radionuclide therapy. Semin Nucl Med. 2001;31:330–341
  13. Bishayee A, Rao DV, Srivastava SC, Bouchet LG, Bolch WE, Howell RW. Marrow-sparing effects of 117mSn(4+)diethylenetriamine-pentaacetic acid for radionuclide therapy of bone cancer. J Nucl Med. 2000;41:2043–2050
  14. Lam MGEH, de Klerk JMH, van Rijk PP, Zonnenberg BA. Bone seeking radiopharmaceuticals for palliation of pain in cancer patients with osseous metastases. Anticancer Agents Med Chem. 2007;7:381–397
  15. McEwan AJB. Use of radionuclides for the palliation of bone metastases. Semin Radiat Oncol. 2000;10:103–114
  16. Serafini AN. Therapy of metastatic bone pain. J Nucl Med. 2001;42:895–906
  17. McEwan AJB. Palliation of bone pain. In:  Murray IPC,  Ell PJ editor. Nuclear medicine in clinical diagnosis and treatment. London: Churchill Livingstone; 1998;p. 1083–1099
  18. Ramamoorthy N, Saraswathy P, Das MK, Mehra KS, Ananthakrishnan M. Production logistics and radionuclidic purity aspects of 153Sm for radionuclide therapy. Nucl Med Commun. 2002;23:83–89
  19. Ando A, Ando I, Tonami N, Kinuya S, Kazuma K, Kataiwa A, et al. 177Lu-EDTMP: a potential therapeutic bone agent. Nucl Med Commun. 1998;19:587–591
  20. Sola GAR, Arguelles MG, Bottazzini DL, Furnari JC, Parada IG, Rojo A, et al. Lutetium-177-EDTMP for bone pain palliation. Preparation, biodistribution and preclinical studies. Radiochim Acta. 2000;88:157–161
  21. Chakraborty S, Das T, Unni PR, Sarma HD, Samuel G, Banerjee S, et al. 177Lu-labeled polyaminophosphonates as potential agents for bone pain palliation. Nucl Med Commun. 2002;23:67–74
  22. Das T, Chakraborty S, Unni PR, Banerjee S, Samuel G, Sarma HD, et al. 177Lu labeled cyclic polyaminophosphonates as potential agents for bone pain palliation. Appl Radiat Isot. 2002;57:177–184
  23. Das T, Chakraborty S, Sarma HD Banerjee S. 177Lu-DOTMP: a viable agent for palliative radiotherapy of painful bone metastasis. Radiochim Acta. 2008;96:55–61
  24. Chakraborty S, Das T, Banerjee S, Balogh L, Chaudhari PR, Sarma HD, et al. 177Lu-EDTMP: a viable bone pain palliative in skeletal metastasis. Cancer Biother Radiopharm. 2008;23:202–213
  25. Firestone R. In:  Shirley VS editors. 8th ed.. Table of isotopes. New York: John Wiley and Sons; 1996;p. 1982–1983
  26. Chakraborty S, Das T, Banerjee S, Chaudhari PR, Sarma HD, Venkatesh M, et al. Preparation and biological evaluation of 153Sm-DOTMP as a potential agent for bone pain palliation. Nucl Med Commun. 2004;25:1169–1176
  27. Awasthi V, Meinken G, Springer K, Srivastava SC, Freimuth P. Biodistribution of radioiodinated adenovirus fiber protein knob domain after intravenous injection in mice. J Virol. 2004;78:6431–6438
  28. Panagi Z, Beletsi A, Evangelatos G, Livaniou E, Jthakissos DS, Avagoustakis K. Effect of dose on the biodistribution and pharmacokinetics of PLGA and PLGA-mPEG nanoparticles. Int J Pharm. 2001;221:143–152
  29. Das T, Chakraborty S, Banerjee S, Sarma HD, Samuel G, Venkatesh M. 177Lu labeled metronidazole for possible use in targeting tumor hypoxia. Radiochim Acta. 2006;94:375–380
  30. Singh A, Holmes RA, Farhangi M, Volkert WA, Williams A, Stringham LM, et al. Human pharmacokinetics of samarium-153-EDTMP in metastatic cancer. J Nucl Med. 1989;30:1814–1818
  31. Knapp FF, Mirzadeh S, Garland MA. The continuing important role of high flux research reactors for production of therapeutic radioisotopes. In: Proc. of International Symposium on Trends in Radiopharmaceuticals — 2005. Vienna, Austria: IAEA; 2007;p. 301–321
  32. http://www.iaea.org/worldatom/rrdb.
  33. Appelbaum F, Brown P, Sandmaier B, Badger C, Schuening F, Graham T, et al. Antibody-radionuclide conjugates as part of a myeloablative preparative regimen for marrow transplantation. Blood. 1989;73:2202–2208

PII: S0969-8051(09)00076-6

doi: 10.1016/j.nucmedbio.2009.02.002

Nuclear Medicine and Biology
Volume 36, Issue 5 , Pages 561-568 , July 2009

Article Tools

* Image Usage & Resolution