Nuclear Medicine and Biology
Volume 36, Issue 2 , Pages 137-146 , February 2009

Tumor targeting and SPECT imaging properties of an 111In-labeled galectin-3 binding peptide in prostate carcinoma

  • Susan L. Deutscher

      Affiliations

    • Department of Biochemistry, University of Missouri–Columbia School of Medicine, Columbia, MO 65211, USA
    • Research Division, Harry S. Truman Veterans Hospital, Columbia, MO 65201, USA
    • ,
  • Said D. Figueroa

      Affiliations

    • Research Division, Harry S. Truman Veterans Hospital, Columbia, MO 65201, USA
    • ,
  • Senthil R. Kumar

      Affiliations

    • Department of Biochemistry, University of Missouri–Columbia School of Medicine, Columbia, MO 65211, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 573 814 6000x53747; fax: +1 573 882 5635.

Received 19 June 2008 ,Revised 15 October 2008 ,Accepted 27 October 2008.

References 

  1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics. CA Cancer J Clin. 2007;57:43–66
  2. Stetler-Stevenson WG, Aznavoorian S, Liotta LA. Tumor cell interactions with the extracellular matrix during invasion and metastasis. Ann Rev Cell Biol. 1993;9:541–573
  3. Liotta LA. Cancer cell invasion and metastasis. Sci Am. 1992;266:54–63
  4. Inohara H, Raz A. Functional evidence that cell surface galectin-3 mediates homotypic cell adhesion. Cancer Res. 1995;55:3267–3271
  5. Bussemakers MJ, Schalken JA. The role of cell adhesion molecules and proteases in tumor invasion and metastasis. World J Urol. 1996;14:151–156
  6. Barondes SH, Cooper DN, Gitt MA, Leffler H. Galectins. Structure and function of a large family of animal lectins. J Biol Chem. 1994;269:20807–20810
  7. Sato S, Hughes RCJ. Regulation of secretion and surface expression of Mac-2, a galactoside binding protein of macrophages. J Biol Chem. 1994;269:4424–4430
  8. Moutsatsos IK, Wade M, Schindler M, Wang JL. Endogenous lectins from cultured cells: nuclear localization of carbohydrate binding protein 35 in proliferating 3T3 fibroblasts. Proc Natl Acad Sci USA. 1987;84:6452–6456
  9. Perillo NL, Marcus ME, Baum LG. Galectins: versatile modulators of cell adhesion, cell proliferation, and cell death. J Mol Med. 1998;76:402–412
  10. Sato S, Burdett I, Hughes RC. Secretion of the baby hamster kidney 30-kDA galactose binding lectin from polarized and nonpolarized cells: a pathway independent of the endoplasmic reticulum–Golgi complex. Exp Cell Res. 1993;207:8–18
  11. Wang I, Inohara H, Pienta KJ, Raz A. Galectin-3 is a nuclear matrix protein which binds RNA. Biochem Biophys Res Commun. 1995;217:292–303
  12. Raz A, Lotan R. Lectin-like activities associated with human and murine neoplastic cells. Cancer Res. 1981;41:3642–3647
  13. Raz A, Zhu D, Hogan V, Shan N, Raz T, Karkash R, et al. Evidence for the role of 34-kDa galactoside-binding lectin in transformation and metastasis. Int J Cancer. 1990;46:871–877
  14. Inohara H, Akahani S, Koths S, Raz A. Interactions between galectin-3 and Mac-2-binding protein mediate cell–cell adhesion. Cancer Res. 1996;56:4530–4534
  15. Glinsky VV, Glinsky GV, Rittenhouse-Olson K, Huflejt ME, Glinskii OV, Deutscher SL, et al. The role of Thomsen–Friedenreich antigen in adhesion of human breast and prostate cancer cells to the endothelium. Cancer Res. 2001;61:4851–4857
  16. Lehr JE, Pienta KJ. Preferential adhesion of prostate cancer cells to a human bone marrow endothelial cell line. J Natl Cancer Inst. 1998;90:118–123
  17. Glinsky VV, Glinsky GV, Glinskii OV, Huxley VH, Turk JR, Mossine VV, et al. Intravascular metastatic cancer cell homotypic aggregation at the sites of primary attachment to the endothelium. Cancer Res. 2003;63:3805–3811
  18. Nangia-Makker P, Hogan V, Honjo Y, Baccarini S, Tait L, Bresalier R, et al. Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin. J Natl Cancer Inst. 2002;94:1854–1862
  19. Glinsky GV, Price JE, Glinsky VV, Mosine VV, Kiriakova G, Metcalf JB. Inhibition of human breast cancer metastasis in nude mice by synthetic glycoamines. Cancer Res. 1996;56:5319–5324
  20. Zuo J, Glinsky VV, Landon LA, Mathews L, Deutscher SL. Peptides specific to the galectin-3 carbohydrate recognition domain inhibit metastasis-associated cancer cell adhesion. Carcinogenesis. 2005;26:309–318
  21. Kumar SR, Quinn T, Deutscher SL. Evaluation of 111In-radiolabeled peptide as a targeting and imaging agent for ErbB-2 receptor-expressing breast carcinomas. Clin Cancer Res. 2007;20:6070–6079
  22. Kumar SR, Deutscher SL. 111In-labeled galectin-3-targeting peptide as a SPECT agent for imaging breast tumors. J Nucl Med. 2008;49:796–803
  23. Iurisci I, Tinari N, Natoli C, Angelucci D, Cianchetti E, Iacobelli S. Concentrations of galectin-3 in the sera of normal controls and cancer patients. Clin Cancer Res. 2000;6:1389–1393
  24. Ahemed H, Banerjee PP, Vasta GR. Differential expression of galectins in normal, benign and malignant prostate epithelial cells: silencing of galectin-3 expression in prostate cancer by its promoter methylation. Biochem Biophys Res Commun. 2007;358:241–246
  25. Pacis RA, Pilat MJ, Pienta KJ, Wojno K, Raz A, Hogan V, et al. Decreased galectin-3 expression in prostate cancer. Prostate. 2000;44:118–123
  26. Schubiger PA, Alberto A, Smith A. Vehicles, chelators, and radionuclides: choosing the building blocks of an effective therapeutic radioimmunoconjugate. Bioconj Chem. 1996;7:165–179
  27. Furtak V, Hatcher F, Ochieng J. Galectin-3 mediates the endocytosis of beta-1 integrins by breast carcinoma cells. Biochem Biophy Res Commun. 2001;289:845–850
  28. Zhu WQ, Ocheing J. Rapid release of intracellular galectin-3 from breast carcinoma cells by fetuin. Cancer Res. 2001;61:1869–1873
  29. Mørgenson CE, Sølling K. Studies on renal tubular protein re-absorption: partial and near complete inhibition by certain amino acids. Scand J Clin Lab Invest. 1977;37:477–486
  30. Silbernagl S. The renal handling of amino acids and oligopeptides. Physiol Rev. 1988;68:912–986
  31. Maack T, Johnson V, Kan ST, Figueiredo J, Sigulem D. Renal filtration, transport, and metabolism of low molecular weight proteins: a review. Kidney Int. 1979;16:251–270
  32. Miao Y, Owen NK, Whitener D, Gallazzi F, Hoffman T, Quinn TP. In vivo evaluation of 188Re labeled alpha-melanocyte hormone stimulating hormone peptide analogs for melanoma therapy. Int J cancer. 2002;101:480–487
  33. Behr TM, Starkey RM, Juweid ME, Blumenthal RD, Dunn RM, Griffiths GL, et al. Reduction of the renal uptake of radiolabeled monoclonal antibody fragments by cationic amino acids and their derivatives. Cancer Res. 1995;55:3825–3834
  34. Rolleman EJ, Valkema R, de Jong M, Kooij PPM, Krenning EP. Safe and effective inhibition of renal uptake of radiolabelled octreotide by a combination of lysine and arginine. Eur J Nucl Med Mol Imaging. 2003;30:9–15
  35. Perik PJ, Lub-De Hooge MN, Gietema JA, van der Graaf WTA, Alexander de Korte M, Jonkman S, et al. Indium-111-labeled trastuzumab scintigraphy in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer. J Clin Oncol. 2006;24:2276–2281
  36. van Eerd JEM, Vegt E, Wetzels JFM, Russel FGM, Masereeuw R, Corstens FHM, et al. Gelatin-based plasma expander effectively reduces renal uptake of 111In-octreotide in mice and rats. J Nucl Med. 2006;47:528–533
  37. Vegt E, Wetzels JFM, Russell FGM, Masereeuw R, Boerman OC, van Eerd JE, et al. Renal uptake of radiolabeled octreotide in human subjects is efficiently inhibited by succinylated gelatin. J Nucl Med. 2006;47:432–436
  38. Tolmachev V, Orlova A, Pehrson R, Galli J, Baastrup B, Andersson K, et al. Radionuclide therapy of HER2-specific affibody molecule. Cancer Res. 2007;67:2773–2782
  39. Sehgal I, Foster TP, Francis J. Prostate cancer cells show elevated urokinase receptor in a mouse model of metastasis. Cancer Cell Int. 2006;6:21
  40. Foster BA, Kaplan PJ, Greenburg NM. Peptide growth factors and prostate cancer: new models, new opportunities. Cancer Metastasis Rev. 1999;17:317–324
  41. Hurwitz AA, Foster BA, Allison JP, Greenberg NM, Kwon ED. The TRAMP mouse as a model for prostate cancer. Curr Protoc Immunol. 2001;[Chapter 20: Unit 20.5]
  42. Arap W, Kolonin MG, Trepel M, Lahdenranta J, Cardó-Vila M, Giordano RJ, et al. Steps toward mapping the human vasculature by phage display. Nat Med. 2002;8:121–127

PII: S0969-8051(08)00239-4

doi: 10.1016/j.nucmedbio.2008.10.015

Nuclear Medicine and Biology
Volume 36, Issue 2 , Pages 137-146 , February 2009

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