Nuclear Medicine and Biology
Volume 36, Issue 1 , Pages 73-79 , January 2009

Evaluation of 99mTc(CO)5I as a potential lung perfusion agent

  • Alexander E. Miroslavov

      Affiliations

    • Division of Radiochemical Research, Khlopin Radium Institute, 2nd Murinskii pr. 28, 194021, St Petersburg, Russia
    • ,
  • Nikolay I. Gorshkov

      Affiliations

    • Division of Radiochemical Research, Khlopin Radium Institute, 2nd Murinskii pr. 28, 194021, St Petersburg, Russia
    • ,
  • Alexander L. Lumpov

      Affiliations

    • Division of Radiochemical Research, Khlopin Radium Institute, 2nd Murinskii pr. 28, 194021, St Petersburg, Russia
    • ,
  • Anatoly N. Yalfimov

      Affiliations

    • Nuclear Medicine Department, Central Research Institute of Roentgenology and Radiology, Leningradskaya str. 70/4, 197000, St Petersburg, Russia
    • ,
  • Dmitrii N. Suglobov

      Affiliations

    • Division of Radiochemical Research, Khlopin Radium Institute, 2nd Murinskii pr. 28, 194021, St Petersburg, Russia
    • ,
  • Beverley L. Ellis

      Affiliations

    • Department of Nuclear Medicine, Manchester Royal Infirmary, M13 9WL Manchester, UK
    • Corresponding Author InformationCorresponding author. Tel.: +441612768759; fax: +441612768023.
    • ,
  • Rattana Braddock

      Affiliations

    • Imaging Science and Biomedical Engineering, School of Cancer and Imaging Science, Stopford Building, The University of Manchester, Oxford Road, Manchester M13 9PT
    • ,
  • Anne-Marie Smith

      Affiliations

    • Imaging Science and Biomedical Engineering, School of Cancer and Imaging Science, Stopford Building, The University of Manchester, Oxford Road, Manchester M13 9PT
    • ,
  • Mary C. Prescott

      Affiliations

    • Department of Nuclear Medicine, Manchester Royal Infirmary, M13 9WL Manchester, UK
    • ,
  • Richard S. Lawson

      Affiliations

    • Department of Nuclear Medicine, Manchester Royal Infirmary, M13 9WL Manchester, UK
    • ,
  • Harbans L. Sharma

      Affiliations

    • Imaging Science and Biomedical Engineering, School of Cancer and Imaging Science, Stopford Building, The University of Manchester, Oxford Road, Manchester M13 9PT

Received 22 April 2008 ,Revised 15 October 2008 ,Accepted 27 October 2008.

References 

  1. Parker JA, Coleman RE, Hilson AJW, Royal HD, Siegel BA, Sostman HD. Society of Nuclear Medicine Procedure Guideline for Lung Scintigraphy. Version 3.0, 2004 http://interactive.snm.org/docs/Lung%20scintigraphy_v3.0.pdf
  2. Worsley DF, Alavi A. Radionuclide imaging of acute pulmonary embolism. Semin Nucl Med. 2003;33:259–278
  3. Kowalsky RJ, Falen SW. Radiopharmaceuticals in nuclear pharmacy and nuclear medicine. 2nd ed.. Washington: American Pharmacists Association; 2004;
  4. Alberto R, Pak JK, Van Staveren D, Mundwiler S, Benny P. Mono-, bi-, or tridentate ligands? The labeling of peptides with 99mTc-carbonyls. Biopolymers (Peptide Science). 2004;76:324–333
  5. Alberto R, Ortner K, Wheatley N, Shibli R, Schubiger AP. Synthesis and properties of boranocarbonate: a convenient in situ CO source of the aqueous preparation of [99mTc(OH2)3(CO3)]+. J Amer Chem Soc. 2001;123:3135–3136
  6. Schwochau K. Technetium. Chemistry and radiopharmaceutical application. New York: Wiley; 2000;
  7. Hileman JC, Higgins DK, Kaesz HD. Derivative of technetium carbonyl. Synthesis and properties of the carbonyl halides and the pentacarbonyl hydride. Inorg Chem. 1962;1(4):933–938
  8. Gorshkov NI, Lumpov AA, Miroslavov AE, Suglobov DN. Procedure for preparing water-soluble carbonyl complexes of short-lived Technetium(I) and Rhenium(I). 1999;[RF Patent no. 2125017]
  9. Miroslavov AE, Lumpov AA, Sidorenko GV, Levitskaya EM, Gorshkov NI, Suglobov DN, et al. Complexes of technetium(I) (99Tc, 99mTc) pentacarbonyl core with π-acceptor ligands (tert-butyl isocyanide and triphenylphosphine): Crystal structures of [Tc(CO)5(PPh3)OTf and [Tc(CO)5(CNC(CH3)3]ClO4. J Organomet Chem. 2008;693:4–10
  10. Suglobov DN, Miroslavov AE, Levitskaya EM, Gorshkov NI, Lumpov AA, Sidorenko GV. High pressure synthesis of higher technetium-99m carbonyls as potential precursors for development of new radiopharmaceuticals. In:  Mazzi U editors. Technetium, rhenium and other metals in chemistry and nuclear medicine. Padova: SGEditorial; 2006;p. 503–505
  11. Kotel’nikova AS, Suglobov DN, Tsarenko AF, Legin EK, Miroslavov AE, Sidorenko GV. Procedure for preparing technetium pentacarbonyl halides, USSR inventor’s certificate no 1512003 (priority June 11, 1987, registered June 1, 1989).
  12. Grigor'ev MS, Miroslavov AE, Sidorenko GV, Suglobov DN. Crystal and molecular structure of 99Tc(CO)5I. Radiochemistry. 1997;38:204–206
  13. British Nuclear Medicine Society Clinical Procedure Guidelines . Ventilation/perfusion imaging for pulmonary embolic disease. London: British Nuclear Medicine Society; 2003;http://www.bnmsonline.co.uk
  14. Whinnery JE, Young JT. Granulomatous interstitial pneumonia in a miniature swine associated with repeated intravenous injections of Tc-99m human serum albumin: concise communication. J Nucl Med. 1980;21:207–210
  15. Perkins AC, Frier M. Bad blood and biologicals; the need for new radiopharmaceutical source materials. Nucl Med Commun. 1999;20:1–3
  16. Borisova IV, Miroslavov AE, Sidorenko GV, Suglobov DN. Tensiometric study of technetium carbonyl compounds. Radiokhimiya. 1991;33:9–13
  17. European Pharmacopeia . 5th ed.. Strasbourg: European Directorate for the Quality of Medicines; 2005;

☆ This work was also partially funded by the British Heart Foundation (Grant No. PG/03/011/15027).

PII: S0969-8051(08)00238-2

doi: 10.1016/j.nucmedbio.2008.10.017

Nuclear Medicine and Biology
Volume 36, Issue 1 , Pages 73-79 , January 2009

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