Nuclear Medicine and Biology
Volume 36, Issue 1 , Pages 65-71 , January 2009

Uptake of 99mTc-labeled chondroitin sulfate by chondrocytes and cartilage: a promising agent for imaging of cartilage degeneration?

  • Grazyna Sobal

      Affiliations

    • Department of Nuclear Medicine, Medical University of Vienna, Vienna 1090, Austria
    • Corresponding Author InformationCorresponding author. Tel.: +43 1 40400 5558; fax: +43 1 40400 5552.
    • ,
  • Johannes Menzel

      Affiliations

    • Institute of Immunology, Medical University of Vienna, Vienna 1090, Austria
    • ,
  • Helmut Sinzinger

      Affiliations

    • Department of Nuclear Medicine, Medical University of Vienna, Vienna 1090, Austria

Received 28 August 2008 ,Revised 20 October 2008 ,Accepted 25 October 2008.

References 

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  3. Bourgeois P, Chales G, Dehais J, Delcambre B, Kuntz JL, Rozenberg S. Efficacy and tolerability of chondroitin sulfate 1200 mg per day vs. 3×400 mg per day vs. placebo. Osteoarthritis Cartilage. 1998;6:25–30
  4. Ronca F, Palmieri L, Pinicucci P, Ronca G. Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis Cartilage. 1998;6SA:14–21
  5. Uebelhart D, Thonar EJMA, Delmas PD, Chantraine A, Vignon E. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis, a pilot study. Osteoarthritis Cartilage. 1998;6:39–46
  6. Uebelhart D, Thonar EJMA, Zhang J, Williams JM. Protective effect of exogenous chondroitin 4,6-sulfate in the acute degradation of articular cartilage in the rabbit. Osteoarthritis Cartilage. 1998;6:6–13
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  11. Sobal G, Menzel EJ, Sinzinger H. Radiolabeling procedure, quality control and stability of (99m)Tc-labeled chondroitin sulfate: A new approach of targeting osteoarthritis. Appl Radiat Isot. 2008;66:415–420
  12. Sobal G, Sinzinger H. Binding studies with (99mTc) chondroitin sulfate on chondrocytes as compared to binding of modified (125I) LDL on macrophages. J Recept Signal Transduct Res. 2002;22:459–470
  13. Camejo G, Rosengren B, Olson U, Lopez F, Olofson SO, Westerlund C, et al. Molecular basis of the association of arterial proteoglycans with low density lipoproteins. Its effect on the structure of the lipoprotein particle. Eur Heart J. 1990;11(Suppl. E):164–173
  14. Kaplan M, Aviram M. Macrophage plasma membrane chondroitin sulfate proteoglycan binds oxidized low-density lipoprotein. Atherosclerosis. 2000;149:5–17
  15. Fujimoto T, Kawashima H, Tanaka T, Hirose M, Toyama-Sorimachi N, Matsuzawa Y, et al. CD44 binds a chondroitin sulfate proteoglycan, aggrecan. Int Immunol. 2001;13:359–366
  16. Blanco FJ, Guitian R, Vazquez-Martul E, de Toro FJ, Galdo F. Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology. Arthritis Rheum. 1998;41:259–284
  17. Hashimoto S, Takahashi K, Amiel D, Coutts RD, Lotz M. Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis. Arthritis Rheum. 1998;41:1266–1274
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PII: S0969-8051(08)00233-3

doi: 10.1016/j.nucmedbio.2008.10.013

Nuclear Medicine and Biology
Volume 36, Issue 1 , Pages 65-71 , January 2009

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