Nuclear Medicine and Biology
Volume 35, Issue 8 , Pages 901-909 , November 2008

PET scanning of macrophages in patients with scleroderma fibrosing alveolitis

  • Howard M. Branley

      Affiliations

    • Imperial College London, Hammersmith Campus, London, UK
    • Corresponding Author InformationCorresponding author. Department of Respiratory Medicine, The Whittington Hospital, Magdala Avenue, N19 5NF London, UK. Tel.: +44 20 7288 5272; fax: +44 20 7288 5060.
    • ,
  • Roland M. du Bois

      Affiliations

    • Royal Brompton Hospital, London, UK
    • ,
  • Athol U. Wells

      Affiliations

    • Royal Brompton Hospital, London, UK
    • ,
  • Hazel A. Jones

      Affiliations

    • Imperial College London, Hammersmith Campus, London, UK

Received 8 April 2008 ,Revised 11 August 2008 ,Accepted 1 October 2008.

References 

  1. Zavala F, Lenfant M. Benzodiazepines and PK 11195 exert immunomodulating activities by binding on a specific receptor on macrophages. Ann NY Acad Sci. 1987;496:240–249
  2. Ramsay SC, Weiller C, Myers R, Cremer JE, Luthra SK, Lammertsma AA, et al. Monitoring by PET of macrophage accumulation in brain after ischaemic stroke. Lancet. 1992;339(8800):1054–1055
  3. Mak JC, Barnes PJ. Peripheral type benzodiazepine receptors in human and guinea pig lung: characterization and autoradiographic mapping. J Pharmacol ExpTher. 1990;252(2):880–885
  4. Jones HA, Valind SO, Clark IC, Bolden GE, Krausz T, Schofield JB, et al. Kinetics of lung macrophages monitored in vivo following particulate challenge in rabbits. Toxicol Appl Pharmacol. 2002;183(1):46–54
  5. Jones HA, Clark RJ, Rhodes CG, Schofield JB, Krausz T, Haslett C. In vivo measurement of neutrophil activity in experimental lung inflammation. Am J Respir Crit Care Med. 1994;149(6):1635–1639
  6. Jones HA, Sriskandan S, Peters AM, Pride NB, Krausz T, Boobis AR, et al. Dissociation of neutrophil emigration and metabolic activity in lobar pneumonia and bronchiectasis. Eur Respir J. 1997;10(4):795–803
  7. Hardwick MJ, Chen MK, Baidoo K, Pomper MG, Guilarte TR. In vivo imaging of peripheral benzodiazepine receptors in mouse lungs: a biomarker of inflammation. Mol Imaging. 2005;4(4):432–438
  8. Jones HA, Branley HM, Boobis AR, du Bois RM. Macrophage imaging in patients with fibrosing alveolitis. Am J Respir Crit Care Med. 2000;161:A824
  9. Silver RM, Miller KS, Kinsella MB, Smith EA, Schabel SI. Evaluation and management of scleroderma lung disease using bronchoalveolar lavage. Am J Med. 1990;88(5):470–476
  10. Audi SH, Dawson CA, Ahlf SB, Roerig DL. Lung tissue mitochondrial benzodiazepine receptors increase in a model of pulmonary inflammation. Lung. 2002;180(5):241–250
  11. Branley HM, du Bois RM, Wells AU, Jones HA. Peripheral-type benzodiazepine receptors in bronchoalveolar lavage cells of patients with interstitial lung disease. Nucl Med Biol. 2007;34(5):553–558
  12. Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria C. Preliminary criteria for the classification of systemic sclerosis (scleroderma). 1980;581–90
  13. Jones HA, Marino PS, Shakur BH, Morrell NW. In vivo assessment of lung inflammatory cell activity in patients with COPD and asthma. Eur Respir J. 2003;21(4):567–573
  14. Brudin LH, Rhodes CG, Valind SO, Wollmer P, Hughes JM. Regional lung density and blood volume in nonsmoking and smoking subjects measured by PET. J Appl Physiol. 1987;63(4):1324–1334
  15. Robb RA, Hanson DP. A software system for interactive and quantitative visualization of multidimensional biomedical images. Australas Phys Eng Sci Med. 1991;14(1):9–30
  16. Rhodes CG, Wollmer P, Fazio F, Jones T. Quantitative measurement of regional extravascular lung density using positron emission and transmission tomography. J Comput Assist Tomogr. 1981;5(6):783–791
  17. Lentner C. Geigy scientific tables. 8th ed. Basle: Ciba-Geigy; 1984;
  18. Jones JG, Minty BD, Royston D. The physiology of leaky lungs. Br J Anaesth. 1982;54(7):705–721
  19. Kon OM, Daniil Z, Black CM, du Bois RM. Clearance of inhaled technetium-99m-DTPA as a clinical index of pulmonary vascular disease in systemic sclerosis. Eur Respir J. 1999;13(1):133–136
  20. Harrison NK, Glanville AR, Strickland B, Haslam PL, Corrin B, Addis BJ, et al. Pulmonary involvement in systemic sclerosis: the detection of early changes by thin section CT scan, bronchoalveolar lavage and 99mTc-DTPA clearance. Respir Med. 1989;83(5):403–414
  21. Mintun MA, Raichle ME, Kilbourn MR, Wooten GF, Welch MJ. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol. 1984;15(3):217–227
  22. Cohen GM. Caspases: the executioners of apoptosis. Biochem.J. 1997;326(Pt 1):1–16
  23. Hirsch T, Decaudin D, Susin SA, Marchetti P, Larochette N, Resche-Rigon M, et al. PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection. Exp Cell Res. 1998;241(2):426–434
  24. Carayon P, Portier M, Dussossoy D, Bord A, Petitpretre G, Canat X, et al. Involvement of peripheral benzodiazepine receptors in the protection of hematopoietic cells against oxygen radical damage. Blood. 1996;87(8):3170–3178
  25. Momosaki S, Hosoi R, Takai N, Gee A, Inoue O. The apparent positive cooperativity of in vivo [3H]PK-11195 binding in mouse fibrosarcoma. Nucl Med Biol. 2006;33(6):797–800
  26. Amitani M, Zhang MR, Noguchi J, Kumata K, Ito T, Takai N, et al. Blood flow dependence of the intratumoral distribution of peripheral benzodiazepine receptor binding in intact mouse fibrosarcoma. Nucl Med Biol. 2006;33(8):971–975
  27. Wollmer P, Rhodes CG, Hughes JM. Regional extravascular density and fractional blood volume of the lung in interstitial disease. Thorax. 1984;39(4):286–293

☆ This work was funded by the Raynaud's and Scleroderma Association of the United Kingdom.

PII: S0969-8051(08)00200-X

doi: 10.1016/j.nucmedbio.2008.10.001

Nuclear Medicine and Biology
Volume 35, Issue 8 , Pages 901-909 , November 2008

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