Nuclear Medicine and Biology
Volume 35, Issue 6 , Pages 673-678 , August 2008

Enhancement of somatostatin-receptor-targeted 177Lu-[DOTA0-Tyr3]-octreotide therapy by gemcitabine pretreatment-mediated receptor uptake, up-regulation and cell cycle modulation

  • Tapan K. Nayak

      Affiliations

    • College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
    • Department of Cell Biology and Physiology, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA
    • Current address: Radiation Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
  • ,
  • Robert W. Atcher

      Affiliations

    • College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
    • Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
  • ,
  • Eric R. Prossnitz

      Affiliations

    • Department of Cell Biology and Physiology, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA
    • Cancer Research and Treatment Center, University of New Mexico, Albuquerque, NM 87131, USA
  • ,
  • Jeffrey P. Norenberg

      Affiliations

    • College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
    • Cancer Research and Treatment Center, University of New Mexico, Albuquerque, NM 87131, USA
    • Corresponding Author InformationCorresponding author. College of Pharmacy, University of New Mexico, Albuquerque, NM 87131 0001, USA.

Received 27 February 2008 ,Revised 30 April 2008 ,Accepted 9 May 2008.

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PII: S0969-8051(08)00110-8

doi: 10.1016/j.nucmedbio.2008.05.003

Nuclear Medicine and Biology
Volume 35, Issue 6 , Pages 673-678 , August 2008