Nuclear Medicine and Biology
Volume 35, Issue 6 , Pages 707-712 , August 2008

In vitro evaluation of canine leukocytes radiolabeled in whole blood with 99mTc stannous colloid

  • Mohamed H. Abushhiwa

      Affiliations

    • Faculty of Veterinary Science, The University of Melbourne, Werribee, Victoria 3030, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61 3 9731 2060; fax: +61 3 9731 2246.
  • ,
  • Nouria S. Salehi

      Affiliations

    • Department of Nuclear Medicine, Royal Melbourne Hospital, Parkville, Victoria 3052, Australia
  • ,
  • Robert C. Whitton

      Affiliations

    • Faculty of Veterinary Science, The University of Melbourne, Werribee, Victoria 3030, Australia
  • ,
  • Jennifer A. Charles

      Affiliations

    • Faculty of Veterinary Science, The University of Melbourne, Werribee, Victoria 3030, Australia
  • ,
  • Peter J. Finnin

      Affiliations

    • Faculty of Veterinary Science, The University of Melbourne, Werribee, Victoria 3030, Australia
  • ,
  • Peter M. Lording

      Affiliations

    • Faculty of Veterinary Science, The University of Melbourne, Werribee, Victoria 3030, Australia
  • ,
  • Ivan W. Caple

      Affiliations

    • Faculty of Veterinary Science, The University of Melbourne, Werribee, Victoria 3030, Australia
  • ,
  • Bruce W. Parry

      Affiliations

    • Faculty of Veterinary Science, The University of Melbourne, Werribee, Victoria 3030, Australia

Received 8 April 2008 ,Accepted 29 April 2008.

References 

  1. Van der Laken CJ, Boerman OC, Oyen WJG, Van de Ven MTP, Van der Meer JWM, Corstens FHM. Scintigraphic detection of infection and inflammation: new developments with special emphasis on receptor interaction. Eur J Nucl Med. 1998;25:535–546
  2. Rennen HJJM, Boerman OC, Oyen WJG, Corstens FHM. Imaging infection/inflammation in the new millennium. Eur J Nucl Med. 2001;28:241–252
  3. Becker W, Bair J, Behr T, Repp R, Steckenbach H, Beck H, et al. Detection of soft-tissue infection and osteomyelitis using a technetium-99m-labeled anti-granulocyte monoclonal antibody fragment. J Nucl Med. 1994;35:1436–1443
  4. Becker W, Palestro CJ, Winship J, Feld T, Pinsky CM, Wolf F, et al. Rapid imaging of infection with a monoclonal antibody fragment (Leukoscan). Clin Orthop. 1996;329:263–272
  5. Fischman AJ, Pike MC, Kroon D, Fucello AJ, Rexinger D, Kate C, et al. Imaging focal sites of bacterial infection in rats with indium-111-labeled chemotactic peptide analogs. J Nucl Med. 1991;32:483–491
  6. Van der Laken CJ, Boerman OC, Oyen WJG, Van de Ven MTP, Claessens RAMJ, Van der Meer JWM, et al. Specific targeting of infectious foci with radioiodinated human recombinant interleukin-1 in an experimental model. Eur J Nucl Med. 1995;22:1249–1255
  7. Signore A, Chianelli M, Toscano A, Monetinil L, Ronga G, Nimmon CC, et al. A radiopharmaceutical for imaging areas of lymphocytic infiltration, 123I-interleukin-2 labeling procedure and animal studies. Nucl Med Commun. 1992;13:713–722
  8. Moyer BR, Vallabhajosula S, Lister-James J, Bush LR, Cyr JE, Snow DA, et al. Technetium-99m-white blood cell-specific imaging agent developed from platelet factor 4 to detect infection. J Nucl Med. 1996;37:673–679
  9. Schroth HJ, Oberhausen E, Berberich R. Cell labelling with colloidal substances in whole blood. Eur J Nucl Med. 1981;6:469–472
  10. Hughes DK. Nuclear medicine and infection detection: the relative effectiveness of imaging with 111In-oxine-, 99mTc-HMPAO-, and 99mTc-stannous fluoride colloid-labelled leucocytes and with 67Ga-citrate. J Nucl Med. 2003;31:196–201
  11. Hanna R, Braun T, Levendel A, Lomas F. Radiochemistry and biostability of autologous leucocytes labelled with 99mTc-stannous colloid in whole blood. Eur J Nucl Med. 1984;9:216–219
  12. Hanna RW, Lomas F. Identification of factors affecting technetium-99m leucocyte labelling by phagocytic engulfment and development of an optimal technique. Eur J Nucl Med. 1986;12:159–162
  13. Southee AE, Lee KJ, Mclaughlin AF, Borham PW, Bautovich GJ, Morris JG. Tc-99m white cell scintigraphy in suspected acute infection. Clin Nucl Med. 1990;15:71–75
  14. Boyd SJ, Nour R, Quinn RJ, McKay E, Butler SP. Evaluation of white cell scintigraphy using indium-111 and technetium-99m labelled leukocytes. Eur J Nucl Med. 1993;20:201–206
  15. Ramsay SC, Labrooy J, Norton R, Webb B. Demonstration of different patterns of musculoskeletal, soft tissue and visceral involvement in melioidosis using 99mTc stannous colloid white cell scanning. Nucl Med Commun. 2001;22:1193–1199
  16. Peacock K, Porn U, Howman-Giles R, O'Loughlin E, Uren R, Gaskin K. 99mTc-stannous colloid white cell scintigraphy in childhood inflammatory bowel disease. J Nucl Med. 2004;45:261–265
  17. Tsopelas C. The radiopharmaceutical chemistry of 99mTc-tin fluoride colloid-labelled-leucocytes. Q J Nucl Med Imaging. 2005;49:319–324
  18. Puncher MP, Blower PJ. Labelling of leucocytes with colloid technetium-99m-SnF2: an investigation of the labelling process by autoradiography. Eur J Nucl Med. 1995;22:101–107
  19. Mock BH, English D. Leucocyte labeling with technetium-99m tin colloid. J Nucl Med. 1987;28:1471–1477
  20. Gallagher H, Ramsay SC, Barnes J, Magges J, Cassidy N, Ketheesan N. Neutrophil labeling with [99mTc]-technetium stannous colloid is complement receptor 3-mediated and increases the neutrophil priming response to lipopolysaccharide. Nucl Med Biol. 2006;33:433–439
  21. Pullman WE, Sullivan PJ, Barratt PJ, Lising J, Booth JA, Doe WF. Assessment of inflammatory bowel disease activity by technetium 99m phagocyte scanning. Gastroenterology. 1988;95:989–996
  22. Gibson P, Lichtenstein M, Salehi N, Hebbard G, Andrews J. Value of positive technetium-99m leucocyte scans in predicting intestinal inflammation. Gut. 1991;32:1502–1507
  23. Carter NJ, Eustance CN, Barrington SF. Imaging of abdominal infection using 99mTc stannous fluoride colloid labelled leukocytes. Nucl Med Commun. 2002;23:153–160
  24. Abushhiwa M, Salehi N, Slocombe R, Finnin P, Caple I, Lording P, et al. Tc-99m tin fluoride colloid: efficiency of labelling equine and canine leucocytes and effect on cell viability. ANZ Nucl Med. 2006;37:1–3
  25. Hirsch JI, Tatum JL, Fratkin MJ, Apostolides DL, Quint RI. Preparation and evaluation of a Tc-99m SnF2 colloid kit for leucocyte labeling. J Nucl Med. 1989;30:1257–1263
  26. McClelland CM, Onuegbulem E, Carter NJ, Leahy M, O'Doherty MJ, Pooly FD, et al. 99mTc-SnF colloid ‘LLK’: particle size, morphology and leucocyte labelling behaviour. Nucl Med Commun. 2003;24:191–202
  27. Capriotti G, D'Alessandria C, Garin E, Weber E, Devillers A, Lehmann K, et al. An in vitro study to compare 99mTc-stannous colloid and 99mTc-HMPAO for labelling human leucocytes. Q J Nucl Med. 2004;48:229–236
  28. Tucker RL, Daniel GB, Daniel SL, Buckman T. In vitro evaluation of canine granulocytes labeled with 99mTc-hexamethylpropyleneamine oxime: a comparison with 111Indium oxine. Vet Radiol Ultrasound. 1992;33:241–246

PII: S0969-8051(08)00106-6

doi: 10.1016/j.nucmedbio.2008.04.009

Nuclear Medicine and Biology
Volume 35, Issue 6 , Pages 707-712 , August 2008