Nuclear Medicine and Biology
Volume 35, Issue 5 , Pages 529-536 , July 2008

The importance of high specific radioactivity in the performance of 68Ga-labeled peptide

  • Irina Velikyan

      Affiliations

    • Uppsala Applied Science Lab, GEMS PET Systems, GE Healthcare, SE-752 28 Uppsala, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46 18 180917; fax: +46 18 180912.
    • ,
  • Gerd J. Beyer

      Affiliations

    • Cyclotron Unit, Geneva University Hospital, 1211 Geneva, Switzerland
    • ,
  • Elisabeth Bergström-Pettermann

      Affiliations

    • Uppsala Imanet, GE Healthcare, SE-751 09 Uppsala, Sweden
    • ,
  • Pernilla Johansen

      Affiliations

    • Uppsala Imanet, GE Healthcare, SE-751 09 Uppsala, Sweden
    • ,
  • Mats Bergström

      Affiliations

    • Department of Pharmaceutical Biosciences, Uppsala University, Uppsala Biomedical Centre, SE-751 24 Uppsala, Sweden
    • ,
  • Bengt Långström

      Affiliations

    • Uppsala Applied Science Lab, GEMS PET Systems, GE Healthcare, SE-752 28 Uppsala, Sweden
    • Department of Biochemistry and Organic Chemistry, BMC, Uppsala University, Box 599, SE-751 24 Uppsala, Sweden

Received 20 September 2007 ,Revised 14 February 2008 ,Accepted 4 March 2008.

References 

  1. Eary JF. PET imaging for planning cancer therapy. J Nucl Med. 2001;42:770–771
  2. Bernhardt P, Kolby L, Johanson V, Nilsson O, Ahlman H, Forssell-Aronsson E. Biodistribution of 111in-DTPA-D-Phe1-octreotide in tumor-bearing nude mice: influence of amount injected and route of administration. Nucl Med Biol. 2003;30:253–260
  3. de Jong M, Breeman WA, Bernard BF, van Gameren A, de Bruin E, Bakker WH, et al. Tumour uptake of the radiolabelled somatostatin analogue [DOTA0, TYR3]octreotide is dependent on the peptide amount. Eur J Nucl Med. 1999;26:693–698
  4. Green MA, Welch MJ. Gallium radiopharmaceutical chemistry. Nucl Med Biol. 1989;16:435–448
  5. Pearson RG. Hard and soft acids and bases. J Am Chem Soc. 1963;85:3533–3539
  6. Maecke HR, Hofmann M, Haberkorn U. (68)Ga-labeled peptides in tumor imaging. J Nucl Med. 2005;46(Suppl 1):172S–1728S
  7. Velikyan I, Beyer GJ, Langstrom B. Microwave-supported preparation of 68Ga-bioconjugates with high specific radioactivity. Bioconjugate Chem. 2004;15:554–560
  8. Velikyan I, Långström B. Microwave method for preparing radiolabelled gallium complexes. 2004;USA: WO 2004/089425
  9. Velikyan I, Långström B, Beyer G. Method of obtaining gallium-68 and use thereof and device for carrying out said method. 2004;USA: WO 2004/089517
  10. Reubi JC, Schär JC, Waser B, Wenger S, Heppeler A, Schmitt JS, et al. Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use. Eur J Nucl Med Mol Imaging. 2000;27:273–282
  11. Hoz A, Diaz-Ortiz A, Moreno A. Microwaves in organic synthesis. Thermal and non-thermal microwave effects. Chem Soc Rev. 2005;34:164–178
  12. Heppeler A, Froidevaux S, Macke HR, Jermann E, Behe M, Powell P, et al. Radiometal-labelled macrocyclic chelator-derivatised somatostatin analogue with superb tumour-targeting properties and potential for receptor-mediated internal radiotherapy. Chem-Eur J. 1999;5:1974–1981
  13. Kraus KA, Nelson F. Anion exchange studies of the fission products. In: Conference on Peaceful Uses of Atomic Energy. United Nations. 1956;p. 113–125
  14. Prata MI, Santos AC, Geraldes CF, de Lima JJ. Characterisation of 67Ga3+complexes of triaza macrocyclic ligands: biodistribution and clearance studies. Nucl Med Biol. 1999;26:707–710
  15. Eisenwiener KP, Prata MI, Buschmann I, Zhang HW, Santos AC, Wenger S, et al. NODAGATOC, a new chelator-coupled somatostatin analogue labeled with [67/68Ga] and [111In] for SPECT, PET, and targeted therapeutic applications of somatostatin receptor (hsst2) expressing tumors. Bioconjug Chem. 2002;13:530–541
  16. Velikyan I, Maecke H, Langstrom B. Convenient Preparation of (68)Ga-Based PET-Radiopharmaceuticals at Room Temperature. Bioconjug Chem. 2008;
  17. Greenwood NN. The chemistry of gallium. Adv Inorg Chem Radiochem. 1963;5:91–134

PII: S0969-8051(08)00072-3

doi: 10.1016/j.nucmedbio.2008.03.002

Nuclear Medicine and Biology
Volume 35, Issue 5 , Pages 529-536 , July 2008

Article Tools

* Image Usage & Resolution