Metabolic comparison of radiolabeled aniline- and phenol-phthaleins with 131I

Avcıbaşı, Uğur; Avcıbaşı, Nesibe; Ünak, Turan; Ünak, Perihan; Müftüler, Fazilet Zümrüt; Yıldırım, Yeliz; Dinçalp, Haluk; Gümüşer, Fikriye Gül; Dursun, Ebru Rükşen

doi:10.1016/j.nucmedbio.2008.02.003

« Previous Next »Nuclear Medicine and Biology
Volume 35, Issue 4 , Pages 481-492, May 2008

Metabolic comparison of radiolabeled aniline- and phenol-phthaleins with ¹³¹I

Uğur Avcıbaşı
- Department of Chemistry, Faculty of Art and Science, Celal Bayar University, 45030 Manisa, Turkey
- Corresponding author. Tel.: +90 236 2412151 158; fax: +90 236 2412158.
Nesibe Avcıbaşı
- Ege Vocational Training School, Ege University, Bornova, 35100 Izmir, Turkey
Turan Ünak
- Division of Nuclear Chemistry, Department of Chemistry, Ege University, Faculty of Science, Bornova, 35100 Izmir, Turkey
Perihan Ünak
- Department of Nuclear Applications, Ege University, Institute of Nuclear Sciences, Bornova, 35100 Izmir, Turkey
Fazilet Zümrüt Müftüler
- Department of Nuclear Applications, Ege University, Institute of Nuclear Sciences, Bornova, 35100 Izmir, Turkey
Yeliz Yıldırım
- Division of Nuclear Chemistry, Department of Chemistry, Ege University, Faculty of Science, Bornova, 35100 Izmir, Turkey
Haluk Dinçalp
- Department of Chemistry, Faculty of Art and Science, Celal Bayar University, 45030 Manisa, Turkey
Fikriye Gül Gümüşer
- Department of Nuclear Medicine, Celal Bayar University, School of Medicine, 45030 Manisa, Turkey
Ebru Rükşen Dursun
- Department of Nuclear Medicine, Celal Bayar University, School of Medicine, 45030 Manisa, Turkey

Received 11 May 2007; received in revised form 7 February 2008; accepted 14 February 2008.

Abstract

The metabolic comparison of aniline- and phenol-phthaleins radiolabeled with ¹³¹I (¹³¹I-APH and ¹³¹I-PPH, respectively) has been investigated in this study. To compare the metabolic behavior of these phthaleins and their glucuronide conjugates radiolabeled with ¹³¹I, scintigraphic and biodistributional techniques were applied using male Albino rabbits. The results obtained have shown that these compounds were successfully radioiodinated with a radioiodination yield of about 100%. Maximum uptakes of ¹³¹I-APH and ¹³¹I-PPH, which were metabolized as N- and O-glucuronides, were observed within 2 h in the bladder and in the small intestine, respectively. In the case of verification of considerably up taking of these compounds also by tumors developed in the small intestine and in the bladder tissues, these results can be expected to be encouraging to test these compounds, which will be radiolabeled with other radioiodines such as ¹²⁵I, ¹²³I and ¹²⁴I as imaging and therapeutic agents in nuclear medical applications.

Keywords: Aniline-phthalein, Phenol-phthalein, ¹³¹I, Scintigraphy, Glucuronidation, Bladder, Intestine