Nuclear Medicine and Biology
Volume 35, Issue 4 , Pages 475-479 , May 2008

Metabolism and autoradiographic evaluation of [18F]FE@CIT: a Comparison with [123I]β-CIT and [123I]FP-CIT

  • Dagmar E. Ettlinger

      Affiliations

    • Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
    • ,
  • Daniela Häusler

      Affiliations

    • Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
    • Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
    • ,
  • Wolfgang Wadsak

      Affiliations

    • Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
    • Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
    • ,
  • Friedrich Girschele

      Affiliations

    • Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
    • ,
  • Karoline M. Sindelar

      Affiliations

    • Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
    • ,
  • Leonhard-Key Mien

      Affiliations

    • Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
    • Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
    • Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
    • ,
  • Johanna Ungersböck

      Affiliations

    • Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
    • Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
    • ,
  • Helmut Viernstein

      Affiliations

    • Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
    • ,
  • Kurt Kletter

      Affiliations

    • Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
    • ,
  • Robert Dudczak

      Affiliations

    • Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
    • ,
  • Markus Mitterhauser

      Affiliations

    • Corresponding Author InformationCorresponding author. Department of Nuclear Medicine, AKH Wien, Waehringer Guertel 18-20, A-1090 Vienna, Austria. Tel.: +43 1 40400 1557; fax: +43 1 40400 1559.
    • Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
    • Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
    • Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria

Received 12 December 2007 ,Revised 18 February 2008 ,Accepted 28 February 2008.

References 

  1. Shetty HU, Zoghbi SS, Liow JS, Ichise M, Hong J, Musachio JL, et al. Identification and regional distribution in rat brain of radiometabolites of the dopamine transporter PET radioligand [11C]PE2I. Eur J Nucl Med. 2007;34:667–678
  2. Mitterhauser M, Wadsak W, Mien LK, Hoepping A, Viernstein H, Dudczak R, et al. Synthesis and biodistribution of [18F]FE@CIT, a new potential tracer for the dopamine transporter. Synapse. 2005;55:73–79
  3. Gu XH, Zong R, Kula NS, Baldessarini RJ, Neumeyer JL. Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter. Bioorg Med Chem Lett. 2001;11:3049–3053
  4. Kula NS, Baldessarini RJ, Tarazi FI, Fisser R, Wang S, Trometer J, et al. [3H]beta-CIT: a radioligand for dopamine transporters in rat brain tissue. Eur J Pharmacol. 1999;385:291–294
  5. Wilson AA, DaSilva JN, Houle S. In vivo evaluation of [11C]- and [18F]-labelled cocaine analogues as potential dopamine transporter ligands for positron emission tomography. Nucl Med Biol. 1996;23:141–146
  6. Aquilonius SM, Bergstrom K, Eckernäs SA, Hartvig P, Leenders KL, Lundquist H, et al. In vivo evaluation of striatal dopamine reuptake sites using [11C]nomifensine and positron emission tomography. Acta Neurol Scand. 1987;76:283–287
  7. Kung HF, Kung MP, Choi SR. Radiopharmaceuticals for single-photon emission computed tomography brain imaging. Sem Nucl Med. 2003;33:2–13
  8. Meyer JH, Ichise M. Modeling of receptor ligand data in PET and SPECT imaging: A review of major approaches. J Neuroimaging. 2001;11:30–39
  9. Potter PM, Wadkins RM. Carboxylesterases–detoxifying enzymes and targets for drug therapy. Curr Med Chem. 2006;13:1045–1054
  10. Hosokawa M, Maki T, Satoh T. Characterisation of molecular species of liver microsomal carboxylesterases of several animal species and humans. Arch Biochem Biophys. 1990;277:219–227
  11. Seibyl JP, Marek K, Sheff K, Zoghbi S, Baldwin RM, Charney DS, et al. Iodine-123-beta-CIT and iodine-123-FPCIT SPECT measurement of dopamine transporters in healthy subjects and Parkinson's patients. J Nucl Med. 1998;39:1500–1508
  12. Humerickhouse R, Lohrbach K, Li L, Bosron WF, Dolan ME. Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2. Cancer Res. 2000;60:1189–1192
  13. Ettlinger DE, Wadsak W, Mien LK, Machek M, Wabnegger L, Rendl G, et al. [18F]FETO: metabolic considerations. Eur J Nucl Med Mol Imaging. 2006;33:928–931
  14. Sihver W, Drewes B, Schulze A, Olsson RA, Coenen HH. Evaluation of novel tropane analogues in comparison with the binding characteristics of [18F]FP-CIT and [131I]beta-CIT. Nucl Med Biol. 2007;34:211–219

PII: S0969-8051(08)00064-4

doi: 10.1016/j.nucmedbio.2008.02.008

Nuclear Medicine and Biology
Volume 35, Issue 4 , Pages 475-479 , May 2008

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