Nuclear Medicine and Biology
Volume 35, Issue 3 , Pages 353-357 , April 2008

Chemosorption of radiometals of interest to nuclear medicine by synthetic melanins

  • Robertha C. Howell

      Affiliations

    • Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    • ,
  • Andrew D. Schweitzer

      Affiliations

    • Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    • Howard Hughes Medical Institute—Medical Fellows Program, Chevy Chase, MD 20815, USA
    • ,
  • Arturo Casadevall

      Affiliations

    • Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    • Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    • ,
  • Ekaterina A. Dadachova

      Affiliations

    • Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    • Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    • Corresponding Author InformationCorresponding author. Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Tel.: +1 718 405 8485; fax: +1 718 405 8457.

Received 3 December 2007 ,Revised 23 December 2007 ,Accepted 31 December 2007.

References 

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  2. Nicolaus RA. Melanins. Paris: Hermann; 1968;
  3. Meredith P, Sarna T. The physical and chemical properties of eumelanin. Pigment Cell Res. 2006;19:572–594
  4. Hong L, Simon JD. Current understanding of the binding sites, capacity, affinity, and biological significance of metals in melanin. J Phys Chem B. 2007;111:7938–7947
  5. Turick CE, Caccavo F, Tisa LS. Electron transfer from Shewanella algae BrY to hydrous ferric oxide is mediated by cell-associated melanin. FEMS Microbiol Lett. 2003;99:104
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  7. Mahmoud YA-G. Uptake of radionuclides by some fungi. Mycobiology. 2004;32:110–114
  8. Dadachova E, Bryan RA, Howell RC, Schweitzer AD, Aisen P, Nosanchuk JD, et al. Radioprotective properties of melanin are a function of its chemical composition, free stable radical presence and spatial arrangement. Pigment Cell Melanoma Res [in press].
  9. Dadachova E, Bryan RA, Huang X, Moadel T, Schweitzer AD, Aisen P, et al. Ionizing radiation changes the electronic properties of melanin and enhances the growth of melanized fungi. PLoS One. 2007;5:e457
  10. Dadachova E, Casadevall A. Melanin nanoshells for protection against radiation and electronic pulses. US patent application no. 60/819,992; PCT patent application no. PCT/US2005/035707.
  11. Pazo V, Revskaya E, Howell R, Nosanchuk JD, Casadevall A, Dadachova E. Melanized nanoparticles lodged in the bone marrow have protective effect against external gamma radiation. J Nucl Med. 2006;47(Suppl 1):220P
  12. Ito S, Fujita K. Microanalysis of eumelanin and pheomelanin in hair and melanomas by chemical degradation and liquid chromatography. Anal Biochem. 1985;144:527–536
  13. Boll RA, Malkemus D, Mirzadeh S. Production of actinium-225 for alpha particle mediated radioimmunotherapy. Appl Radiat Isot. 2005;62:667–679
  14. Wang Y, Aisen P, Casadevall A. Melanin, melanin “ghosts,” and melanin composition in Cryptococcus neoformans. Infect Immun. 1996;64:2420–2424
  15. Alexander V. Design and synthesis of macrocyclic ligands and their complexes of lanthanides and actinides. Chem Rev. 1995;95:273–342

PII: S0969-8051(08)00004-8

doi: 10.1016/j.nucmedbio.2007.12.006

Nuclear Medicine and Biology
Volume 35, Issue 3 , Pages 353-357 , April 2008

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