Nuclear Medicine and Biology
Volume 35, Issue 2 , Pages 159-169 , February 2008

Isostructural fluorescent and radioactive probes for monitoring neural stem and progenitor cell transplants

  • Paul Schaffer

      Affiliations

    • McMaster Nuclear Reactor, McMaster University, Hamilton, Ontario, Canada L8S 4K1
  • ,
  • Jacqueline A. Gleave

      Affiliations

    • Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
  • ,
  • Jennifer A. Lemon

      Affiliations

    • Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada L8S 4K1
  • ,
  • Leslie C. Reid

      Affiliations

    • Department of Chemistry, McMaster University, Hamilton, Ontario, Canada L8S 4M1
  • ,
  • Laura K.K. Pacey

      Affiliations

    • Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
  • ,
  • Troy H. Farncombe

      Affiliations

    • Department of Nuclear Medicine, Hamilton Health Sciences, Hamilton, Ontario, Canada L8N 3Z5
  • ,
  • Douglas R. Boreham

      Affiliations

    • Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada L8S 4K1
  • ,
  • Jon Zubieta

      Affiliations

    • Department of Chemistry, Syracuse University, Syracuse, NY 13244-4100, USA
  • ,
  • John W. Babich

      Affiliations

    • Molecular Insight Pharmaceuticals Inc., Cambridge, MA 02142, USA
  • ,
  • Laurie C. Doering

      Affiliations

    • Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
  • ,
  • John F. Valliant

      Affiliations

    • Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    • Department of Chemistry, McMaster University, Hamilton, Ontario, Canada L8S 4M1
    • Corresponding Author InformationCorresponding author. Department of Chemistry, McMaster University, 1280 Main St. West, Hamilton, Ontario, Canada L8S 4M1. Tel.: +1 905 525 9140x22840; fax: +1 905 522 7776.

Received 25 July 2007 ,Revised 25 September 2007 ,Accepted 2 November 2007.

References 

  1. Doetsch F, Caillé I, Lim DA, García-Verdugo JM, Alvarez-Buylla A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell. 1999;97:703–716
  2. Goldman S. Stem and progenitor cell-based therapy of the human central nervous system. Nat Biotech. 2005;23:862–871
  3. Lundberg C, Winkler C, Whittemore SR, Björklund A. Conditionally immortalized cells grafted to the striatum exhibit site-specific neuronal connections with the host globus pallidus. Neurobiol Dis. 1996;3:33–50
  4. de Vries IJM, Lesterhuis WJ, Barentsz JO, Verdijk P, van Krieken JH, Boerman OC, et al. Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy. Nat Biotech. 2005;23:1407–1413
  5. Frangioni JV, Hajjar RJ. In vivo tracking of stem cells for clinical trials in cardiovascular disease. Circulation. 2004;110:3378–3384
  6. Ma B, Hankenson KD, Dennis JE, Caplan AI, Goldstein SA, Kilbourn MR. A simple method for stem cell labeling with fluorine 18. Nucl Med Biol. 2005;32:701–705
  7. Brenner W, Aicher A, Eckey T, Massoudi S, Zuhayra M, Koehl U, et al. 111In-labeled CD34+ hematopoietic progenitor cells in a rat myocardial infarction model. J Nucl Med. 2004;45:512–518
  8. Chin BB, Nakamoto Y, Bulte JWM, Pittenger MF, Wahl R, Kraitchman DL. 111In oxine labelled mesenchymal stem cell SPECT after intravenous administration in myocardial infarction. Nucl Med Commun. 2003;24:1149–1154
  9. Aicher A, Brenner W, Zuhayra M, Badorff C, Massoudi S, Assmus B, et al. Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling. Circulation. 2003;107:2134–2139
  10. Bai J, Ding W, Yu M, Du J, Liu Z, Jia B, et al. Radionuclide imaging of mesenchymal stem cells transplanted into spinal cord. Neuroreport. 2004;15:1117–1120
  11. Ford JW, Welling TH, Stanley JC, Messina LM. PKH26 and 125I-PKH95: characterization and efficacy as labels for in vitro and in vivo endothelial cell localization and tracking. J Surg Res. 1996;62:23–28
  12. Gao J, Dennis JE, Muzic RF, Lundberg M, Caplan AI. The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion. Cells Tissues Organs. 2001;169:12–20
  13. Zhou R, Thomas DH, Qiao H, Bal HS, Choi S-R, Alavi A, et al. In vivo detection of stem cells grafted in infarcted rat myocardium. J Nucl Med. 2005;46:816–821
  14. Jin Y, Kong H, Stodilka RZ, Wells RG, Zabel P, Merrifield PA, et al. Determining the minimum number of detectable cardiac-transplanted 111In-tropolone-labelled bone-marrow-derived mesenchymal stem cells by SPECT. Phys Med Biol. 2005;50:4445–4455
  15. Kizilian N, Wilkins RC, Reinhardt P, Ferrarotto C, McLean JR, McNamee JP. Silver-stained comet assay for detection of apoptosis. Biotechniques. 1999;27:926–928
  16. Zhao M, Kircher MF, Josephson L, Weissleder R. Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconjug Chem. 2002;13:840–844
  17. Wunderbaldinger P, Josephson L, Weissleder R. Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles. Bioconjug Chem. 2002;13:264–268
  18. Bhorade R, Weissleder R, Nakakoshi T, Moore A, Tung CH. Macrocyclic chelators with paramagnetic cations are internalized into mammalian cells via HIV-Tat derived membrane translocation peptide. Bioconjug Chem. 2000;11:301–305
  19. Lewin M, Carlesso N, Tung C-H, Tang X-W, Cory D, Scadden DT, et al. Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat Biotech. 2000;18:410–414
  20. Gao X, Yang L, Petros JA, Marshall FF, Simons JW, Nie S. In vivo molecular and cellular imaging with quantum dots. Curr Opin Biotech. 2005;16:63–72
  21. Polyakov V, Sharma V, Dahlheimer JL, Pica CM, Luker GD, Piwnica-Worms D. Novel Tat-peptide chelates for direct transduction of technetium-99m and rhenium into human cells for imaging and radiotherapy. Bioconjug Chem. 2000;11:762–771
  22. Säälik P, Elmquist A, Hansen M, Padari K, Saar K, Viht K, et al. Protein cargo delivery properties of cell-penetrating peptides. A comparative study. Bioconjugate Chem. 2004;15:1246–1253
  23. Banerjee SR, Levadala M, Lazarova N, Wei L, Valliant JF, Stephenson KA, et al. Bifunctional single amino acid chelates for labeling of biomolecules with the {Tc(CO)3}+ and {Re(CO)3}+ cores. Crystal and molecular structures of [ReBr(CO)3(H2NCH2C5H4N))], [Re(CO)3{(C5H4NCH2)2NH}]Br, [Re(CO)3{C5H4NCH2)2NCH2CO2H}]Br, [Re(CO)3{X(Y)NCH2CO2CH2CH3}]Br (X=Y=2-pyridylmethyl; X=2-pyridylmethyl, Y=2-(1-methylimidazolyl)methyl; X=Y=2-(1-methylimidazolyl)methyl), [ReBr(CO)3{(C5H4NCH2)NH(CH2C4H3S)}], and Re(CO)3{C5H4NCH2)N(CH2C4H3S)(CH2CO2)}]. Inorg Chem. 2002;41:6417–6425
  24. Banerjee SR, Wei L, Levadala MK, Lazarova N, Golub VO, O'Connor CJ, et al. {ReIIICl3} core complexes with bifunctional single amino acid chelates. Inorg Chem. 2002;41:5795–5802
  25. Stephenson KA, Banerjee SR, Besanger T, Sogbein OO, Levadala MK, McFarlane N, et al. Bridging the gap between in vitro and in vivo imaging: isostructural Re and 99mTc complexes for correlating fluorescence and radioimaging studies. J Am Chem Soc. 2004;126:8598–8599
  26. Kiso Y, Satomi M, Ukawa K, Akita T. Efficient deprotection of NG-tosylarginine with thioanisole-trifluoromethanesulphonic acid system. Chem Commun. 1980;1063–1064
  27. Atherton E, Sheppard RC, Ward P. Peptide synthesis. Part 7. Solid-phase synthesis of conotoxin G1. J Chem Soc Perkin Trans I. 1985;2065–2073
  28. Alberto R, Schibli R, Egli A, Schubiger AP, Abram U, Kadtem TA. A novel organometallic aqua complex of technetium for the labeling of biomolecules: synthesis of [99mTc(OH2)3(CO)3]+ from [99mTcO4] in aqueous solution and its reaction with a bifunctional ligand. J Am Chem Soc. 1998;120:7987–7988
  29. McNamee JP, McLean JRN, Ferrarotto CL, Bellier PV. Comet assay: rapid processing of multiple samples. Mutat Res. 2000;466:63–69
  30. Ryan LA, Wilkins RC, McFarlane NM, Sung MM, McNamee JP, Boreham DR. Relative biological effectiveness of 280 keV neutrons for apoptosis in human lymphocytes. Health Phys. 2006;91:68–75

PII: S0969-8051(07)00276-4

doi: 10.1016/j.nucmedbio.2007.11.001

Nuclear Medicine and Biology
Volume 35, Issue 2 , Pages 159-169 , February 2008