Nuclear Medicine and Biology
Volume 35, Issue 2 , Pages 197-201 , February 2008

IMPY, a potential β-amyloid imaging probe for detection of prion deposits in scrapie-infected mice

  • Pu-Jiao Song

      Affiliations

    • INSERM, U619, F-37000 Tours, France
    • Université François-Rabelais, F-37000 Tours, France
    • IFR135, F-37000 Tours, France
    • ,
  • Serge Bernard

      Affiliations

    • IFR135, F-37000 Tours, France
    • INRA, UR1282, IASP, 37380 Nouzilly, France
    • Corresponding Author InformationCorresponding author. Infectiologie Animale et Santé Publique (IASP), INRA, UR1282, 37380 Nouzilly, France. Tel.: +33 2 47 42 78 86; fax: +33 2 47 42 77 79.
    • ,
  • Pierre Sarradin

      Affiliations

    • INRA, UR1282, IASP, 37380 Nouzilly, France
    • ,
  • Jackie Vergote

      Affiliations

    • INSERM, U619, F-37000 Tours, France
    • Université François-Rabelais, F-37000 Tours, France
    • IFR135, F-37000 Tours, France
    • ,
  • Céline Barc

      Affiliations

    • INRA, UR1282, IASP, 37380 Nouzilly, France
    • ,
  • Sylvie Chalon

      Affiliations

    • INSERM, U619, F-37000 Tours, France
    • Université François-Rabelais, F-37000 Tours, France
    • IFR135, F-37000 Tours, France
    • ,
  • Mei-Ping Kung

      Affiliations

    • Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    • Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    • ,
  • Hank F. Kung

      Affiliations

    • Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    • Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    • ,
  • Denis Guilloteau

      Affiliations

    • INSERM, U619, F-37000 Tours, France
    • Université François-Rabelais, F-37000 Tours, France
    • IFR135, F-37000 Tours, France

Received 17 September 2007 ,Accepted 14 October 2007.

References 

  1. Prusiner SB. Molecular biology of prion diseases. Science. 1991;252:1515–1522
  2. Hoefert VB, Aiken JM, Mckenzie D, Johnson CJ. Labeling of the scrapie-associated prion protein in vitro and in vivo. Neurosci Lett. 2004;371:176–180
  3. Ishikawa K, Doh-ura K, Kudo Y, et al. Amyloid imaging probes are useful for detection of prion plaques and treatment of transmissible spongiform encephalopathies. J Gen Virol. 2004;85:1785–1790
  4. Ishikawa K, Kudo K, Nishida N, et al. Styrylbenzoazole derivatives for imaging of prion plaques and treatment of transmissible spongiform encephalopathies. J Neurochem. 2006;99:198–205
  5. Zhuang ZP, Kung MP, Wilson A, et al. Structure–activity relationship of imidazo[1,2-a]pyridines as ligands for detecting β-amyloid plaques in the brain. J Med Chem. 2003;46:237–243
  6. Kung HF, Kung MP, Zhuang ZP, et al. Iodinated tracers for imaging amyloid plaques in the brain. Mol Imaging Biol. 2003;5:418–426
  7. Kung MP, Hou C, Zhuang ZP, Cross AJ, Maier DL, Kung HF. Characterization of IMPY as a potential imaging agent for β-amyloid plaques in double transgenic PSAPP mice. Eur J Nucl Med Mol Imaging. 2004;31:1136–1145
  8. Prusiner SB. Prions. Proc Natl Acad Sci U S A. 1998;95:13363–13383
  9. Taraboulos A, Jendroska K, Serban D, Yang SL, DeArmond SJ, Prusiner SB. Regional mapping of prion proteins in brain. Proc Natl Acad Sci U S A. 1992;89:7620–7624
  10. Le Dur A, Béringue V, Andreoletti O, et al. A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes. Proc Natl Acad Sci U S A. 2005;102:16031–16036
  11. Andreoletti O, Levavasseur E, Uro-Coste E, et al. Astrocytes accumulate 4-hydroxynonenal adducts in murine scrapie and human Creutzfeldt–Jakob disease. Neurobiol Dis. 2002;11:386–393
  12. Lezmi S, Bencsik A, Baron T. PET-blot analysis contributes to BSE strain recognition in C57BI/6 mice. J Histochem Cytochem. 2006;54:1087–1094
  13. Kung MP, Hou C, Zhuang ZP, et al. IMPY: an improved thioflavin-T derivative for in vivo labeling of β-amyloid plaques. Brain Res. 2002;956:202–210
  14. Kung MP, Hou C, Zhuang ZP, Skovronky D, Kung HF. Binding of two potential imaging agents targeting amyloid plaques in postmortem brain tissues of patients with Alzheimer's disease. Brain Res. 2004;1025:98–105
  15. Newberg AB, Wintering NA, Plössl K, et al. Safety, biodistribution, and dosimetry of 123I-IMPY: a novel amyloid plaque-imaging agent for the diagnosis of Alzheimer's disease. J Nucl Med. 2006;47:748–754

PII: S0969-8051(07)00253-3

doi: 10.1016/j.nucmedbio.2007.10.005

Nuclear Medicine and Biology
Volume 35, Issue 2 , Pages 197-201 , February 2008

Article Tools

* Image Usage & Resolution