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Nuclear Medicine and Biology
Volume 35, Issue 2
, Pages 177-183
, February 2008
Ex vivo evaluation of N-(3-[18F]fluoropropyl)-2β-carbomethoxy-3β-(4-fluorophenyl)nortropane in rats
References
- . The dopamine transporter: potential involvement in neuropsychiatric disorders. In: Bloom FE, Kupfer DJ editor. Psychopharmacology: the fourth generation of progress. New York: Raven Press, Ltd; 1995;p. 179–188
- . Localization and dynamic regulation of biogenic amine transporters in the mammalian central nervous system. Front Neuroendocrinol. 1998;19:187–231
- . Neurotransmitter transporters in the central nervous system. Pharmacol Rev. 1999;51:439–464
- . Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci. 2003;4:13–25
- . The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. J Neurosci. 1996;16:436–447
- . Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. J Neurosci. 1997;17:5255–5262
- The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens. J Neurosci. 1997;17:6899–6907
- . PET studies of brain monoamine transporters. Curr Pharm Des. 2000;6:1611–1623
- . The dopamine transporter: role in neurotoxicity and human disease. Toxicol Appl Pharmacol. 2005;204:355–360
- . Usefulness of a dopamine transporter PET ligand [18F]β-CFT in assessing disability in Parkinson's disease. J Neurol Neurosurg Psychiatry. 1999;67:737–741
- Compounds affecting the central nervous system: 4. 3β-Phenyltropane-2-carboxylic esters and analogs. J Med Chem. 1973;16:1260–1267
- . Cocaine receptor: biochemical characterization and structure–activity relationships of cocaine analogues at the dopamine transporter. J Med Chem. 1992;35:969–981
- In vivo imaging of baboon and human dopamine transporters by positron emission tomography using [11C]WIN 35,428. Synapse. 1993;15:130–142
- . [18F]CFT ([18F]WIN 35,428), a radioligand to study the dopamine transporter with PET: biodistribution in rats. Synapse. 1996;23:321–327
- Synthesis, biodistribution, and primate imaging of fluorine-18 labeled 2β-carbo-1′-fluoro-2-propoxy-3β-(4-chlorophenyl)tropanes. Ligands for the imaging of dopamine transporters by positron emission tomography. J Med Chem. 2000;43:639–648
- Synthesis and ligand binding of nortropane derivatives: N-substituted 2β-carbomethoxy-3β-(4′-iodophenyl)nortropane and N-(3-iodoprop-(2E)-enyl)-2β-carbomethoxy-3β-(3′,4′-disubstituted phenyl)nortropane. New high-affinity and selective compounds for the dopamine transporter. J Med Chem. 1997;40:1366–1372
- [11C]β-CIT, a cocaine analogue. Preparation, autoradiography and preliminary PET investigations. Nucl Med Biol. 1993;20:249–255
- . PET study of [11C]β-CIT binding to monoamine transporters in the monkey and human brain. Synapse. 1994;16:93–103
- [O-Methyl-11C]β-CIT-FP, a potential radioligand for quantitation of the dopamine transporter: preparation, autoradiography, metabolite studies, and positron emission tomography examinations. Nucl Med Biol. 1995;22:905–913
- . [18F]β-CIT-FP is superior to [11C]β-CIT-FP for quantitation of the dopamine transporter. Nucl Med Biol. 1997;24:621–627
- Radiosynthesis of [18F]N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4-iodophenyl)nortropane and the first human study with positron emission tomography. Nucl Med Biol. 1996;23:999–1004
- Dopamine transporter imaging with fluorine-18-FPCIT and PET. J Nucl Med. 1998;39:1521–1530
- 18F-Labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters. Nucl Med Biol. 2000;27:1–12
- Initial human PET imaging studies with the dopamine transporter ligand 18F-FECNT. J Nucl Med. 2003;44:855–861
- . [18F]CFT ([18F]WIN 35,428), a radioligand to study the dopamine transporter with PET: characterization in human subjects. Synapse. 1998;28:244–250
- . Potential of [18F]β-CFT-FE (2β-carbomethoxy-3β-(4-fluorophenyl)-8-(2-[18F]fluoroethyl)nortropane) as a dopamine transporter ligand: a PET study in the conscious monkey brain. Synapse. 2004;54:37–45
- . N-[18F]fluoroalkyl-CFT: synthesis and cerebral distribution. J Label Compd Radiopharm. 1995;37:55–57
- Preparation of [18F]β-CFT-FP and [11C]β-CFT-FP, selective radioligands for visualisation of the dopamine transporter using positron emission tomography (PET). J Label Compd Radiopharm. 2000;43:1235–1244
- Labeling of the dopamine transporter ligand β-CFT-FP with 18F or 11C. J Label Compd Radiopharm. 1999;42(Suppl 1):S414–S416
- Autoradiographic examination of a new dopamine transporter radioligand, carbon-11 β-CFT-FP, in the post mortem human brain. Eur J Nucl Med. 2000;27:1221
- . Simplified synthesis of N-(3-[18F]fluoropropyl)-2β-carbomethoxy-3β-(4-fluorophenyl)nortropane ([18F]β-CFT-FP) using [18F]fluoropropyl tosylate as the labelling reagent. J Label Compd Radiopharm. 2005;48:463–471
- . The rat brain in stereotaxic coordinates. San Diego: Academic Press; 1986;
- . The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines. Pharmacol Ther. 2001;91:35–62
- Fluorine-18-FPCT: a PET radiotracer for imaging dopamine transporters. J Nucl Med. 1997;38:119–126
- Fluorine-18-labeled tropane analogs for PET imaging studies of the dopamine transporter. Synapse. 2000;37:109–117
- . Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: specific inhibitors of dopamine uptake. Eur J Pharmacol. 1984;103:241–248
- . The dopamine uptake inhibitor GBR 12909: selectivity and molecular mechanism of action. Eur J Pharmacol. 1989;166:493–504
- . Selective labeling of serotonin uptake sites in rat brain by [3H]citalopram contrasted to labeling of multiple sites by [3H]imipramine. J Pharmacol Exp Ther. 1987;242:364–371
- . Immunocytochemical detection of the serotonin transporter in rat brain. Neuroscience. 1996;73:217–231
- . Cell-type-specific expression of catecholamine transporters in the rat brain. J Neurosci. 1994;14:4903–4914
- . Serotonin, dopamine and norepinephrine transporter mRNAs: heterogeneity of distribution and response to ‘binge’ cocaine administration. Mol Brain Res. 1997;49:95–102
- . Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. Mol Brain Res. 2001;87:124–143
- . The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density. BMC Genet. 2005;6:55
- Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-carbazole (Rimcazole): irreversible ligands for the dopamine transporter. J Med Chem. 1997;40:4340–4346
- . Cationic and anionic requirements for the binding of 2β-carbomethoxy-3β-(4-fluorophenyl) [3H]tropane to the dopamine uptake carrier. J Neurochem. 1993;61:167–177
- . Cocaine receptors labeled by [3H]2β-carbomethoxy-3β-(4-fluorophenyl)tropane. Mol Pharmacol. 1989;36:518–524
- . Different pattern of reduction of striatal dopamine reuptake sites in Alzheimer's disease and ageing. J Neural Transm. 2001;108:827–836
- . Dopamine uptake sites in Parkinson's disease and in dementia of the Alzheimer type. Brain Res. 1994;637:262–266
- The functional domains of dopamine transporter for cocaine analog, CFT binding. Exp Mol Med. 2002;34:90–94
PII: S0969-8051(07)00245-4
doi: 10.1016/j.nucmedbio.2007.09.006
© 2008 Elsevier Inc. All rights reserved.
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Nuclear Medicine and Biology
Volume 35, Issue 2
, Pages 177-183
, February 2008
