Nuclear Medicine and Biology
Volume 35, Issue 1 , Pages 53-59 , January 2008

Synthesis, radiolabeling and baboon SPECT imaging of 2β-carbomethoxy-3β-(3′-[123I]iodophenyl)tropane ([123I]YP256) as a serotonin transporter radiotracer

  • Frederic Bois

      Affiliations

    • Yale University, School of Medicine, VA Connecticut HCS (116A2), West Haven, CT 06516, USA
    • ,
  • Ronald M. Baldwin

      Affiliations

    • Yale University, School of Medicine, VA Connecticut HCS (116A2), West Haven, CT 06516, USA
    • ,
  • Louis Amici

      Affiliations

    • Yale University, School of Medicine, VA Connecticut HCS (116A2), West Haven, CT 06516, USA
    • ,
  • Mohammed S. Al-Tikriti

      Affiliations

    • Yale University, School of Medicine, VA Connecticut HCS (116A2), West Haven, CT 06516, USA
    • ,
  • Nora Kula

      Affiliations

    • Department of Psychiatry and Neuroscience Program, Harvard Medical School, Mailman Research Center McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
    • ,
  • Ross Baldessarini

      Affiliations

    • Department of Psychiatry and Neuroscience Program, Harvard Medical School, Mailman Research Center McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
    • ,
  • Robert B. Innis

      Affiliations

    • Yale University, School of Medicine, VA Connecticut HCS (116A2), West Haven, CT 06516, USA
    • ,
  • Julie K. Staley

      Affiliations

    • Yale University, School of Medicine, VA Connecticut HCS (116A2), West Haven, CT 06516, USA
    • ,
  • Gilles D. Tamagnan

      Affiliations

    • Yale University, School of Medicine, VA Connecticut HCS (116A2), West Haven, CT 06516, USA
    • Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 203 401 4309; fax: +1 203 789 2119.

Received 18 May 2006 ,Revised 5 September 2007 ,Accepted 7 September 2007.

References 

  1. Bernheimer H, Birkmayer W, Hornykiewicz O, Jellinger K, Seitelberger F. J Neurol Sci. 1973;20:415–455
  2. Kaufman MJ, Madras BK. Synapse. 1991;49:43–49
  3. Niznik HB, Fogel EF, Fassos FF, Seeman P. J Neurochem. 1991;56:192–198
  4. Haberland N, Hetey L. J Neural Transm. 1987;1:227–230
  5. Owens MJ, Nemeroff CB. Clin Chem. 1994;77(40):288–295
  6. Neumeyer JL, Wang S, Milius RA, Baldwin RM, Zea-Ponce Y, Hoffer PB, et al. J Med Chem. 1991;34:3144–3146
  7. Pike VW. Nucl Med Biol. 1995;22:1011–1018
  8. Dannals RF, Scheffel UA, Suehiro M, Ricaurte GA. Med Chem Res. 1994;5:228–244
  9. Crouzel C, Guillaume M, Barre L, Lemaire C, Pike VW. Nucl Med Biol. 1992;19:857–870
  10. Eckelman WC, Mathis CA. Nucl Med Biol. 2006;33:161–164
  11. Szabo Z, Scheffel U, Mathews WB, Ravert HT, Szabo K, Kraut M, et al. J Cereb Blood Flow Metab. 1999;19:967–981
  12. Buck A, Gucker PM, Schonbachler RD, Arigoni M, Kneifel S, Vollenweider FX, et al. J Cereb Blood Flow Metab. 2000;20:253–262
  13. Parsey R, Kegeles LS, Hwang D-R, Simpson N, Abi-Dargham A, Mawlawi O, et al. J Nucl Med. 2000;41:1465–1477
  14. Zessin J, Eskola O, Brust P, Bergman J, Steinbach J, Lehikoinen P, et al. Nucl Med Biol. 2001;28:857–863
  15. Brust P, Hinz R, Kuwabara H, Hesse S, Zessin J, Pawelke B, et al. Neuropsychopharmacology. 2003;28:2010–2019
  16. Oya S, Kung MP, Acton PD, Mu M, Hou C, Kung HF. J Med Chem. 1999;42:333–335
  17. Houle S, Ginovart N, Hussey D, Meyer JH, Wilson AA. Eur J Nucl Med. 2000;27:1719–1722
  18. Tarkiainen J, Vercouillie J, Emond P, Sandell J, Hiltunen J, Frangin Y, et al. J Labelled Compd Radiopharm. 2001;44:1013–1023
  19. Blough BE, Abraham P, Lewin AH, Kuhar MJ, Boja JW, Carroll FI. J Med Chem. 1996;39:4027–4035
  20. Davies HML, Saikali E, Huby NJS, Gilliatt VJ, Matasi JJ, Sexton T, et al. J Med Chem. 1994;37:1262–1268
  21. Davies HML, Kuhn LA, Thornley C, Matasi JJ, Sexton T, Childers SR. J Med Chem. 1996;39:2554–2558
  22. Tamagnan G, Baldwin RM, Kula NS, Baldessarini RJ, Innis RB. Bioorg Med Chem Lett. 2000;10:1113–1115
  23. Tamagnan G, Fu X, Baldwin RM, Kula NS, Baldessarini RJ, Innis RB. In: “Synthesis and binding affinities for monoamines transporters of 2β-carbomethoxy-3β-(4-aromatic substituted phenyl) tropanes”; ACS New England Regional Meeting (NERM), Storrs CT. 2000;
  24. Still WC, Kahn M, Mitra A. J Org Chem. 1978;43:2923–2925
  25. Gurevich EV, Joyce JN. Neuropsychopharmacology. 1996;14:309–323
  26. Kula NS, Baldessarini RJ, Tarazi FI, Fisser R, Wang S, Trometer J, et al. Eur J Pharmacol. 1999;385:291–294
  27. Tejani-Butt SM. J Pharmacol Exp Ther. 1992;260:427–436
  28. Peng X, Zhang A, Kula NS, Baldessarini RJ, Neumeyer JL. Bioorg Med Chem Lett. 2004;14:5635–5639
  29. Staley JK, Tamagnan GD, Baldwin RM, Fujita M, Al Tikriti MS, Eshima L, et al. Nucl Med Biol. 2000;27:547–556
  30. Baldwin RM, Zea-Ponce Y, Zoghbi SS, Laruelle M, Al-Tikriti MS, Sybirska EH, et al. Nucl Med Biol. 1993;20:597–606
  31. Johnson EW, Woods SW, Zoghbi SS, McBride BJ, Baldwin RM, Innis RB. Life Sci. 1990;47:1535–1546
  32. Zoghbi SS, Baldwin RM, Seibyl JP, Al-Tikriti MS, Zea-Ponce Y, Laruelle M, et al. Nucl Med Biol. 1992;19:881–888
  33. Elfving B, Madsen J, Knudsen GM. Neuroimaging of the serotonin reuptake site requires high-affinity ligands. Synapse. 2007;61:882–888

PII: S0969-8051(07)00240-5

doi: 10.1016/j.nucmedbio.2007.09.002

Nuclear Medicine and Biology
Volume 35, Issue 1 , Pages 53-59 , January 2008

Article Tools

* Image Usage & Resolution