Nuclear Medicine and Biology
Volume 35, Issue 2 , Pages 233-237, February 2008

Bioevaluation of 32P patch designed for the treatment of skin diseases

  • Maria Jimena Salgueiro

      Affiliations

    • Radioisotope Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, 1113 Buenos Aires, Argentina
    • Corresponding Author InformationCorresponding author. Radioisotope Laboratory, Physics Department, School of Pharmacy and Biochemistry, University of Buenos Aires, 1113 Buenos Aires, Argentina. Tel.: +5411 4964 8202x33; fax: +5411 4964 8202x31.
    • ,
  • Hebe Duran

      Affiliations

    • Radiobiology Department, National Energy Atomic Commission, 1150 Buenos Aires, Argentina
    • ,
  • Monica Palmieri

      Affiliations

    • Biodiversity and Experimental Biology Department, School of Exact and Natural Sciences, University of Buenos Aires, 1113 Buenos Aires, Argentina
    • ,
  • Rosana Pirchio

      Affiliations

    • Dosimetry Department, National Energy Atomic Commission, 1150 Buenos Aires, Argentina
    • ,
  • Vanina Medina

      Affiliations

    • Radioisotope Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, 1113 Buenos Aires, Argentina
    • ,
  • Ricardo Ughetti

      Affiliations

    • Research and Development Department, Laboratorios Bacon SAIC, 1603 Buenos Aires, Argentina
    • ,
  • Maximo Croci

      Affiliations

    • Institute of Immunooncology, Dr. E. Crescenti, 1187 Buenos Aires, Argentina
    • ,
  • Jorge Nicolini

      Affiliations

    • Research and Development Department, Laboratorios Bacon SAIC, 1603 Buenos Aires, Argentina
    • ,
  • Marcela Zubillaga

      Affiliations

    • Radioisotope Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, 1113 Buenos Aires, Argentina

Received 21 June 2007; received in revised form 6 August 2007; accepted 16 August 2007. published online 15 November 2007.

Abstract 

Objective

The objective of this study was to design and evaluate a 32P patch for the treatment of skin diseases.

Materials and Methods

The patch was prepared from chromic phosphate 32P and silicone. Bioelimination and biodistribution in healthy and treated animals, and the therapeutic efficacy of two treatment schemes (single dose and fractionated dose) in an animal model of skin cancer were studied.

Results

Based on the bioelimination and biodistribution studies, no leakage of 32P from the patch was observed. The treated tumors reduced their mean diameter compared to controls. The single-dose therapeutic scheme showed a higher number of complete and partial remissions compared to the fractionated scheme. These results were confirmed by histopathological analysis of the samples.

Conclusion

The 32P patch was designed and produced according to specifications for the treatment of superficial lesions of the skin. Although the 32P patch is an open source, it behaves like a sealed one for use in brachytherapy treatments.

Keywords: 32P, Brachytherapy, Skin cancer, Patch

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PII: S0969-8051(07)00221-1

doi:10.1016/j.nucmedbio.2007.08.004

Nuclear Medicine and Biology
Volume 35, Issue 2 , Pages 233-237, February 2008

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