Nuclear Medicine and Biology
Volume 34, Issue 8 , Pages 933-938 , November 2007

Labeling of autologous monocytes with 99mTc–HMPAO at very high specific radioactivity

  • Formijn J. van Hemert

      Affiliations

    • Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1105 AZ Amsterdam, The Netherlands
    • ,
  • Rogier Thurlings

      Affiliations

    • Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1105 AZ Amsterdam, The Netherlands
    • ,
  • Serge E. Dohmen

      Affiliations

    • Department of Experimental Immunohematology, Sanquin Research Amsterdam, The Netherlands
    • Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1105 AZ Amsterdam, The Netherlands
    • ,
  • Carlijn Voermans

      Affiliations

    • Department of Experimental Immunohematology, Sanquin Research Amsterdam, The Netherlands
    • Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1105 AZ Amsterdam, The Netherlands
    • ,
  • Paul P. Tak

      Affiliations

    • Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1105 AZ Amsterdam, The Netherlands
    • ,
  • Berthe L.F. van Eck-Smit

      Affiliations

    • Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1105 AZ Amsterdam, The Netherlands
    • ,
  • Roelof J. Bennink

      Affiliations

    • Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1105 AZ Amsterdam, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31 20 5665952; fax: +31 20 5669092.

Received 4 April 2007 ,Revised 10 July 2007 ,Accepted 12 July 2007.

References 

  1. Tak PP. Chemokine inhibition in inflammatory arthritis. Best Pract Res Clin Rheumatol. 2006;20:929–939
  2. Tak PP. Effects of infliximab treatment on rheumatoid synovial tissue. J Rheumatol Suppl. 2005;74:31–34
  3. Roca M, Martin-Comin J, Becker W, Bernardo-Filho M, Gutfilen B, Moisan A, et al. A consensus protocol for white blood cells labelling with technetium-99m hexamethylpropylene amine oxime. International Society of Radiolabeled Blood Elements (ISORBE). Eur J Nucl Med. 1998;25:797–799
  4. Palestro CJ. In vivo leukocyte labeling: the quest continues. J Nucl Med. 2007;48:332–334
  5. Becker W, Borst U, Krahe T, Borner W. Tc-99m–HMPAO labelled human platelets: in vitro and in vivo results. Eur J Nucl Med. 1989;15:296–301
  6. Silistreli E, Bekis R, Serbest O, Arslan G, Ulker O, Catalyurek H, et al. Platelet scintigraphy results of heparin versus streptokinase treatment in acute deep vein thrombosis. Scand Cardiovasc J. 2004;38:380–382
  7. Jorgensen C, Couret I, Bologna C, Rossi M, Sany J. Radiolabelled lymphocyte migration in rheumatoid synovitis. Ann Rheum Dis. 1995;54:39–44
  8. Fulgenzi A, Casati R, Colombo FR, Gasparini M, Ferrero E, Bondanza A, et al. Distribution of 99mTc-labeled lymphocytes in control and inflamed rats. Nucl Med Biol. 2004;31:631–638
  9. Ridolfi R, Riccobon A, Galassi R, Giorgetti G, Petrini M, Fiammenghi L, et al. Evaluation of in vivo labelled dendritic cell migration in cancer patients. J Transl Med. 2004;2:27
  10. Fernandez P, Bordenave L, Celerier C, Bareille R, Brouillaud B, Basse-Cathalinat B. A novel potential application for 99mTc–HMPAO: endothelial cell labeling for in vitro investigation of cell-biomaterial interactions. J Nucl Med. 1999;40:1756–1763
  11. Goins B, Klipper R, Rudolph AS, Phillips WT. Use of technetium-99m-liposomes in tumor imaging. J Nucl Med. 1994;35:1491–1498
  12. Bockisch A. Sperm cell dynamics in the female rabbit genital tract after insemination monitored by radiolabeled spermatozoa. J Nucl Med. 1993;34:1134–1139
  13. Kadanali S, Varoglu E, Komec D, Uslu H. Evaluation of active and passive transport mechanisms in genital tracts of IUD-bearing women with radionuclide hysterosalpingoscintigraphy. Contraception. 2001;63:41–45
  14. van Hemert FJ, van Lenthe H, Schimmel KJ, Eck-Smit BL. Preparation, radiochemical purity control and stability of 99mTc-mertiatide (Mag-3). Ann Nucl Med. 2005;19:345–349
  15. Verbruggen AM. Lipophilic tracers for the study of regional cerebral blood flow. In:  Ell PJ,  Gambhir SS editor. Nuclear medicine in clinical diagnosis and treatment. Edinburgh: Churchill Livingstone; 2004;p. 1257–1274
  16. Kuppen PJ, Marinelli A, Camps JA, Pauwels EK, Van De Velde CJ, Fleuren GJ, et al. Biodistribution of lymphokine-activated killer (LAK) cells in Wag rats after hepatic-artery or jugular-vein infusion. Int J Cancer. 1992;52:266–270
  17. Mang'era KO, Vanbilloen HP, Schiepers CW, Verbruggen AM. Stabilisation of high-activity 99mTc-d,l–HMPAO preparations with cobalt chloride and their biological behaviour. Eur J Nucl Med. 1995;22:1163–1172
  18. Jacquier-Sarlin MR, Polla BS, Slosman DO. Oxido-reductive state: the major determinant for cellular retention of technetium-99m–HMPAO. J Nucl Med. 1996;37:1413–1416
  19. Babich JW. Technetium-99m–HMPAO retention and the role of glutathione: the debate continues. J Nucl Med. 1991;32:1681–1683

☆ Millenium Pharmaceuticals supported this work.

PII: S0969-8051(07)00188-6

doi: 10.1016/j.nucmedbio.2007.07.008

Nuclear Medicine and Biology
Volume 34, Issue 8 , Pages 933-938 , November 2007

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