Nuclear Medicine and Biology
Volume 34, Issue 8 , Pages 939-944 , November 2007

[14C]Benzyl acetate is a potential radiotracer for the measurement of glial metabolism in the rat brain

  • Sotaro Momosaki

      Affiliations

    • Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 6 6879 2443; fax: +81 6 6879 2443.
    • ,
  • Rie Hosoi

      Affiliations

    • Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
    • ,
  • Tomoya Sanuki

      Affiliations

    • Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
    • ,
  • Kenichiro Todoroki

      Affiliations

    • Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan
    • ,
  • Masatoshi Yamaguchi

      Affiliations

    • Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan
    • ,
  • Antony Gee

      Affiliations

    • GlaxoSmithkline, Clinical Research Unit, ACCI, CB2 2GC Cambridge, UK
    • Department of Chemistry, Imperial College of London, SW7 2AZ London, UK
    • ,
  • Osamu Inoue

      Affiliations

    • Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan

Received 25 May 2007 ,Revised 21 June 2007 ,Accepted 26 June 2007.

References 

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  9. Hosoi R, Kashiwagi Y, Hatazawa J, Gee A, Inoue O. Glial metabolic dysfunction caused neural damage by short-term ischemia in brain. Ann Nucl Med. 2006;20(5):377–380
  10. Hosoi R, Kashiwagi Y, Tokumura M, Abe K, Hatazawa J, Inoue O. Sensitive reduction in 14C-acetate uptake in a short-term ischemic rat brain. J Stroke Cerebrovasc Dis. 2007;16(2):77–781
  11. Hosoi R, Okada M, Hatazawa J, Gee A, Inoue O. Effect of astrocytic energy metabolism depressant on 14C-acetate uptake in intact rat brain. J Cereb Blood Flow Metab. 2004;24(2):188–190
  12. Inoue O, Hosoi R, Momosaki S, Yamamoto K, Amitani M, Yamaguchi M, et al. Evaluation of [14C]phenylacetate as a prototype tracer for the measurement of glial metabolism in the rat brain. Nucl Med Biol. 2006;33(8):985–989
  13. Mori M, Hosokawa M, Ogasawara Y, Tsukada E, Chiba K. cDNA cloning, characterization and stable expression of novel human brain carboxylesterase. FEBS Lett. 1999;458(1):17–22
  14. Hirose S, Umetani Y, Amitani M, Hosoi R, Momosaki S, Hatazawa J, et al. Role of NMDA receptors in the increase of glucose metabolism in the rat brain induced by fluorocitrate. Neurosci Lett. 2007;415(3):259–263
  15. Gusson F, Carletti M, Albo AG, Dacasto M, Nebbia C. Comparison of hydrolytic and conjugative biotransformation pathways in horse, cattle, pig, broiler chick, rabbit and rat liver subcellular fractions. Vet Res Commun. 2006;30(3):271–283
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PII: S0969-8051(07)00179-5

doi: 10.1016/j.nucmedbio.2007.06.011

Nuclear Medicine and Biology
Volume 34, Issue 8 , Pages 939-944 , November 2007

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