Nuclear Medicine and Biology
Volume 34, Issue 7 , Pages 787-789 , October 2007

Clinical acceptance of a molecular imaging agent: a long march with [99mTc]TRODAT

  • Hank F. Kung

      Affiliations

    • Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    • Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    • Corresponding Author InformationCorresponding author. Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA. Tel.: +1 215 662 3096; fax: +1 215 349 5035.
    • ,
  • Mei-Ping Kung

      Affiliations

    • Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    • ,
  • Shiaw-Pyng Wey

      Affiliations

    • Department of Medical Imaging and Radiological Sciences, Chang Gang University
    • ,
  • Kun-Ju Lin

      Affiliations

    • Molecular Imaging Center, Chang Gang Memorial Hospital, Taoyuan 333, Taiwan
    • Department of Nuclear Medicine, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
    • ,
  • Tzu-Chen Yen

      Affiliations

    • Department of Medical Imaging and Radiological Sciences, Chang Gang University
    • Molecular Imaging Center, Chang Gang Memorial Hospital, Taoyuan 333, Taiwan
    • Department of Nuclear Medicine, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan

Received 23 January 2007 ,Accepted 19 March 2007.

References 

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  2. Kung HF, Kung M-P, Plössl K, Choi SR. 99mTc labeled complexes as brain imaging agents. In:  Mazzi U editors. Technetium, rhenium and other metals in chemistry and nuclear medicine. Padova, Italy: SG Editoriali; 2006;p. 335–370
  3. Chou KL, Hurtig HI, Stern MB, Colcher A, Ravina B, Newberg A, et al. Diagnostic accuracy of [99mTc]TRODAT-1 SPECT imaging in early Parkinson's disease. Parkinsonism Relat Disord. 2004;10:375–379
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  5. Huang WS, Lee MS, Lin JC, Chen CY, Yang YW, Lin SZ, et al. Usefulness of brain 99mTc-TRODAT-1 SPET for the evaluation of Parkinson's disease. Eur J Nucl Med Mol Imaging. 2004;31:155–161
  6. Lai SC, Weng YH, Yen TC, Tsai CC, Chang HC, Wey SP, et al. Imaging early-stage corticobasal degeneration with [99mTc]TRODAT-1 SPET. Nucl Med Commun. 2004;25:339–345
  7. Siderowf A, Newberg A, Chou KL, Lloyd M, Colcher A, Hurtig HI, et al. [99mTc]TRODAT-1 SPECT imaging correlates with odor identification in early Parkinson disease. Neurology. 2005;64:1716–1720
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  10. Huang CC, Weng YH, Lu CS, Chu NS, Yen TC. Dopamine transporter binding in chronic manganese intoxication. J Neurol. 2003;250:1335–1339
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  13. Weng YH, Yen TC, Chen MC, Kao PF, Tzen KY, Chen RS, et al. Sensitivity and specificity of 99mTc-TRODAT-1 SPECT imaging in differentiating patients with idiopathic Parkinson's disease from healthy subjects. J Nucl Med. 2004;45:393–401
  14. Yen TC, Tzen KY, Chen MC, Chou YH, Chen RS, Chen CJ, et al. Dopamine transporter concentration is reduced in asymptomatic Machado-Joseph disease gene carriers. J Nucl Med. 2002;43:153–159
  15. Krause J, Dresel SH, Krause KH, La Fougere C, Zill P, Ackenheil M. Striatal dopamine transporter availability and DAT-1 gene in adults with ADHD: no higher DAT availability in patients with homozygosity for the 10-repeat allele. World J Biol Psychiatry. 2006;7:152–157
  16. Lu CS, Chou YH, Weng YH, Chen RS. Genetic and DAT imaging studies of familial parkinsonism in a Taiwanese cohort. J Neural Transm Suppl. 2006;235–240
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PII: S0969-8051(07)00088-1

doi: 10.1016/j.nucmedbio.2007.03.010

Nuclear Medicine and Biology
Volume 34, Issue 7 , Pages 787-789 , October 2007

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