Nuclear Medicine and Biology
Volume 34, Issue 4 , Pages 433-438 , May 2007

An automated one-step one-pot [18F]FCWAY synthesis: development and minimization of chemical impurities

  • Bik-Kee Vuong

      Affiliations

    • PET Department, Warren Grant Magnuson Clinical Center, Bethesda, MD 20892-1180, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 301 435 8504; fax: +1 301 480 5695.
    • ,
  • Dale O. Kiesewetter

      Affiliations

    • National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
    • ,
  • Lixin Lang

      Affiliations

    • National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
    • ,
  • Ying Ma

      Affiliations

    • National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
    • ,
  • William C. Eckelman

      Affiliations

    • Molecular Tracer LLC, Bethesda, MD 20892, USA
    • ,
  • Michael A. Channing

      Affiliations

    • PET Department, Warren Grant Magnuson Clinical Center, Bethesda, MD 20892-1180, USA

Received 27 December 2006 ,Revised 16 February 2007 ,Accepted 3 March 2007.

References 

  1. Lang LX, Jagoda E, Schmall B, Vuong BV, Adams HR, Nelson DL, et al. Development of fluorine-18-labelled 5-HT1A antagonists. J Med Chem. 1999;42:1576–1586
  2. Carson RE, Lang LX, Watabe H, Der MG, Adams HR, Jagoda E, et al. PET evaluation of [F-18]FCWAY, an analog of the 5-HT1A receptor antagonist. WAY-100635. Nucl Med Biol. 2000;27:493–497
  3. Fletcher A, Bill DJ, Bill SJ, Cliffe IA, Dover GM, Forster EA, et al. WAY-100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. Eur J Pharmacol. 1993;237:283–291
  4. Mathis CA, Simpson NR, Mahmood K, Kinahan PE, Mintun MA. [11C]WAY 100635: a radioligand for imaging 5-HT1A receptors with positron emission tomography. Life Sciences. 1994;55(20):PL403–PL407
  5. Toczek MT, Carson RE, Fazilat S, Lang L, Ma Y, Spanaki MV, et al. PET imaging of 5-HT1A receptor binding in patients with temporal lobe epilepsy. Neurology. 2003;60(5):749–756
  6. Theodore W, Giovacchini G, Toczek M, Bonwetsch R, Eckelman WC, Lang LX, et al. The effect of carbamazepine on PET 5-HT1A ligand binding in patients with temporal lobe epilepsy. Neuroimage. 2004;22:T162–T163
  7. Bonne O, Bain E, Neumeister A, Nugent AC, Vythilingam M, Carson RE, et al. No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder. J. American Psychiatry. 2005;162(2):383–385
  8. Bain EE, Nugent A, Carson RE, Lang LX, Eckelman WC, Neumeister A, et al. Reduced 5-HT1A receptor binding with F-18-FCWAY in bipolar depression. Neuroimage. 2004;22:T167–T168
  9. Neumeister A, Bain E, Nugent AC, Carson RE, Bonne O, Luckenbaugh DA, et al. Reduced serotonin type 1A receptor binding in panic disorder. J Neurosci. 2004;24(3):589–591
  10. Ma Y, Lang L, Kiesewetter DO, et al. Determination of [18F]FCWAY, [18F]FP-TZTP, and their metabolites in plasma using rapid and efficient liquid–liquid and solid phase extractions. Nucl Med Biol. 2003;30(3):233–240
  11. Carson RE, Toczek MT, Lang L, Fraser C, Spanaski V, Ma Y, et al. Human functional imaging with the 5-HT1A ligand [18F]FCWAY. J Nucl. Med. 2002;43(5):198;[Suppl. S]
  12. Carson RE, Wu YJ, Lang LX, Ma Y, Der MG, Herscovitch P, et al. Brain uptake of the acid metabolites of F-18-labeled WAY 100635 analogs. J. Cerebral Blood Flow and Metabolism. 2003;23(2):249–260
  13. Lang L, Eckelman WC. One step radiosynthesis of [18F]FCWAY. J Nucl Med. 2002;43(5):360P
  14. Ma Y, Lang L, Kiesewetter DO, Vuong BK, Channing MA, Ito Y, et al. Purification of the precursor for the automated radiosynthesis of [18F]FCWAY by counter-current chromatography. J Chromatogr A. 2004;1034:149–153
  15. Kiesewetter DO, Vuong BK, Channing MA. The automated radiosynthesis of [18F]FP-TZTP. Nucl Med Biol. 2003;30(1):73–77

PII: S0969-8051(07)00077-7

doi: 10.1016/j.nucmedbio.2007.03.001

Nuclear Medicine and Biology
Volume 34, Issue 4 , Pages 433-438 , May 2007

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