Nuclear Medicine and Biology
Volume 34, Issue 4 , Pages 345-351 , May 2007

One-step high-radiochemical-yield synthesis of [18F]FP-CIT using a protic solvent system

  • Sang Ju Lee

      Affiliations

    • Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea
    • Department of Chemistry, Inha University, Inchon 402-751, South Korea
    • ,
  • Seung Jun Oh

      Affiliations

    • Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82 2 3010 4595; fax: +82 2 3010 4588.
    • ,
  • Dae Yoon Chi

      Affiliations

    • Department of Chemistry, Inha University, Inchon 402-751, South Korea
    • ,
  • Se Hun Kang

      Affiliations

    • Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea
    • ,
  • Hee Seup Kil

      Affiliations

    • Department of Chemistry, Inha University, Inchon 402-751, South Korea
    • ,
  • Jae Seung Kim

      Affiliations

    • Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea
    • ,
  • Dae Hyuk Moon

      Affiliations

    • Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea

Received 8 November 2006 ,Revised 22 January 2007 ,Accepted 16 February 2007.

References 

  1. Laakso A, Bergman J, Haaparanta M, et al. [18F]CFT [[18F]WIN35,428], a radioligand to study the dopamine transporter with PET: characterization in human subjects. Synapse. 1998;28:244–250
  2. Halldin C, Erixon-Lindroth N, Pauli S, et al. [11C]PE2I: a highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain. Eur J Nucl Med Mol Imaging. 2003;30:1220–1230
  3. Davis MR, Votaw JR, Bremner JD, et al. Initial human PET imaging studies with the dopamine transporter ligand 18F-FECNT. J Nucl Med. 2003;44:855–861
  4. Winogrodzka A, Bergmans P, Booij J, et al. [123I]beta-CIT SPECT is a useful method for monitoring dopaminergic degeneration in early stage Parkinson's disease. J Neurol Neurosurg Psychiatry. 2003;74:294–298
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  9. Chaly T, Dhawan V, Kazumata K, et al. Radiosynthesis of [18F]N-3-fluoropropyl-2-beta-carbomethoxy-3-beta-(4-iodophenyl)nortropane and the first human study with positron emission tomography. Nucl Med Biol. 1996;23:999–1004
  10. Goodman MM, Keil R, Shoup TM, et al. Fluorine-18 FPCT: a PET radiotracer for imaging dopamine transporters. J Nucl Med. 1997;38:119–126
  11. Lundkvist C, Halldin C, Ginovart N, et al. [18F]beta-CIT-FP is superior to [11C]beta-CIT-FP for quantitation of the dopamine transporter. Nucl Med Biol. 1997;24:621–627
  12. Lundkvist C, Halldin C, Swahn CG, et al. [O-methyl-11C]beta-CIT-FP, a potential radioligand for quantitation of the dopamine transporter: preparation, autoradiography, metabolite studies, and positron emission tomography examinations. Nucl Med Biol. 1995;22:905–913
  13. Seibyl JP, Marek K, Sheff K, et al. Iodine-123-beta-CIT and iodine-123-FPCIT SPECT measurement of dopamine transporters in healthy subjects and Parkinson's patients. J Nucl Med. 1998;39:1500–1508
  14. Chaly T, Baldwin RM, Neumeyer JL, et al. Radiosynthesis of [18F]N-(3-fluoropropyl)-2-beta-carbomethoxy-3-beta-(4-bromophenyl)nortropane and the regional brain uptake in non human primate using PET. Nucl Med Biol. 2004;31:125–131
  15. Chaly T, Matacchieri R, Dahl R, et al. Radiosynthesis of [18F]N-3-fluoropropyl-2-beta-carbomethoxy-3-beta-(4′-methylphenyl)nortropane (FPCMT). Appl Radiat Isot. 1999;51:299–305
  16. Smith MD, March J. In: Advanced organic chemistry. 5th ed.. New York: Wiley-Interscience; 2001;p. 462–674
  17. Kim DW, Ahn DS, Oh YH, Lee S, Kil HS, Oh SJ, et al. A new class of SN2 reactions catalyzed by protic solvents: facile fluorination for isotopic labeling of diagnostic molecules. J Am Chem Soc. 2006;128:16394–16397

PII: S0969-8051(07)00044-3

doi: 10.1016/j.nucmedbio.2007.02.007

Nuclear Medicine and Biology
Volume 34, Issue 4 , Pages 345-351 , May 2007

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