Nuclear Medicine and Biology
Volume 34, Issue 3 , Pages 233-237 , April 2007

Pharmacokinetics of [18F]fluoroalkyl derivatives of dihydrotetrabenazine in rat and monkey brain

  • Michael R. Kilbourn

      Affiliations

    • Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA
    • Corresponding Author InformationCorresponding author. Cyclotron and Radiochemistry Facility, University of Michigan, Ann Arbor, MI 48109, USA. Tel.: +1 734 763 9246.
    • ,
  • Brian Hockley

      Affiliations

    • Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA
    • ,
  • Lihsueh Lee

      Affiliations

    • Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA
    • ,
  • Catherine Hou

      Affiliations

    • Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
    • ,
  • Rajesh Goswami

      Affiliations

    • Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
    • ,
  • Datta E. Ponde

      Affiliations

    • Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
    • ,
  • Mei-Ping Kung

      Affiliations

    • Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
    • ,
  • Hank F. Kung

      Affiliations

    • Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA

Received 13 November 2006 ,Revised 18 January 2007 ,Accepted 21 January 2007.

References 

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  9. Simpson NR, Souza F, Witkowski P, Maffei A, Raffo A, Herron A, et al. Visualizing pancreatic beta-cell mass with [18F]DTBZ. Nucl Med Biol. 2006;33:855–856
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  12. Kung M-P, Hou C, Goswami R, Ponde DE, Kilbourn MR, Kung HF. Characterization of optically resolved 9-fluoropropyl-dihydrotetrabenazine as a potential PET imaging agent targeting vesicular monoamine transporters. Nucl Med Biol. 2007;34:239–246
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  14. Kilbourn MR. Long-term reproducibility of in vivo measures of specific binding of radioligands in rat brain. Nucl Med Biol. 2004;31:591–595
  15. Koeppe RA, Frey KA, Kuhl DE, Kilbourn MR. Assessment of extrastriatal vesicular monoamine transporter binding site density using stereoisomers of [18F]dihydrotetrabenazine. J Cereb Blood Flow Metab. 1999;9:1376–1384
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☆ This work was supported by grants awarded from the National Institutes of Health (NS-015655 for M.R.K. and EB-002171 for H.F.K.).

PII: S0969-8051(07)00013-3

doi: 10.1016/j.nucmedbio.2007.01.007

Nuclear Medicine and Biology
Volume 34, Issue 3 , Pages 233-237 , April 2007

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