Nuclear Medicine and Biology
Volume 33, Issue 8 , Pages 999-1004 , November 2006

Correlations between 18F-FDG uptake by bone marrow and hematological parameters: measurements by PET/CT

  • Yuji Murata

      Affiliations

    • Department of Radiology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 3 5803 5311; fax: +81 3 5803 0147.
    • ,
  • Kazuo Kubota

      Affiliations

    • Division of Nuclear Medicine, International Medical Center of Japan, Tokyo, 162-8655 Japan
    • ,
  • Masashi Yukihiro

      Affiliations

    • Division of Nuclear Medicine, International Medical Center of Japan, Tokyo, 162-8655 Japan
    • ,
  • Kimiteru Ito

      Affiliations

    • Division of Nuclear Medicine, International Medical Center of Japan, Tokyo, 162-8655 Japan
    • ,
  • Hiroshige Watanabe

      Affiliations

    • Department of Radiology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519, Japan
    • ,
  • Hitoshi Shibuya

      Affiliations

    • Department of Radiology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519, Japan

Received 13 July 2006 ,Revised 20 September 2006 ,Accepted 24 September 2006.

References 

  1. Cook GJ, Maisey MN, Fogelman I. Normal variants, artefacts and interpretative pitfalls in PET imaging with 18-fluoro-2-deoxyglucose and carbon-11 methionine. Eur J Nucl Med. 1999;26:1363–1378
  2. Chiang SB, Rebenstock A, Guan L, Alavi A, Zhuang H. Diffuse bone marrow involvement of Hodgkin lymphoma mimics hematopoietic cytokine-mediated FDG uptake on FDG PET imaging. Clin Nucl Med. 2003;28:674–676
  3. Elstrom RL, Tsai DE, Vergilio JA, Downs LH, Alavi A, Schuster SJ. Enhanced marrow [18F]fluorodeoxyglucose uptake related to myeloid hyperplasia in Hodgkin's lymphoma can simulate lymphoma involvement in marrow. Clin Lymphoma. 2004;5:127
  4. Yao WJ, Hoh CK, Hawkins RA, Glaspy JA, Weil JA, Lee SJ, et al. Quantitative PET imaging of bone marrow glucose metabolic response to hematopoietic cytokines. J Nucl Med. 1995;36:794–799
  5. Knopp MV, Bischoff H, Rimac A, Oberdorfer F, van Kaick G. Bone marrow uptake of fluorine-18-fluorodeoxyglucose following treatment with hematopoietic growth factors: initial evaluation. Nucl Med Biol. 1996;23:845–849
  6. Sugawara Y, Fisher SJ, Zasodny KR, Kison PV, Baker LH, Wahl RL. Preclinical and clinical studies of bone marrow uptake of fluorine-18-fluorodeoxyglucose with or without granulocyte colony-stimulating factor during chemotherapy. J Clin Oncol. 1998;16:173–180
  7. Hollinger EF, Alibazoglu H, Ali A, Green A, Lamonica G. Hematopoietic cytokine-mediated FDG uptake simulates the appearance of diffuse metastatic disease on whole-body PET imaging. Clin Nucl Med. 1998;23:93–98
  8. Lee GR, Bithell TC, Foerster J, Athens JW, Lukens JN. In: Wintrobe's clinical hematology. 9th ed.. Philadelphia, PA: Lea and Febiger; 1983;p. 70
  9. Ramalho AT, Curado MP, Natarajan AT. Lifespan of human lymphocytes estimated during a six year cytogenetic follow-up of individuals accidentally exposed in the 1987 radiological accident in Brazil. Mutat Res. 1995;331:47–54
  10. Hamilton JA, Vairo G, Lingelbach SR. CSF-1 stimulates glucose uptake in murine bone marrow-derived macrophages. Biochem Biophys Res Commun. 1986;138:445–454
  11. Hamilton JA, Vairo G, Lingelbach SR. Activation and proliferation signals in murine macrophages: stimulation of glucose uptake by hemopoietic growth factors and other agents. J Cell Physiol. 1988;134:405–412
  12. Berridge MV, Tan AS. Interleukin-3 facilitates glucose transport in a myeloid cell line by regulating the affinity of the glucose transporter for glucose: involvement of protein phosphorylation in transporter activation. Biochem J. 1995;305:843–851
  13. Ahmed N, Berridge MV. Regulation of glucose transport by interleukin-3 in growth factor-dependent and oncogene-transformed bone marrow-derived cell lines. Leuk Res. 1997;21:609–618
  14. McCoy KD, Ahmed N, Tan AS, Berridge MV. The hemopoietic growth factor, interleukin-3, promotes glucose transport by increasing the specific activity and maintaining the affinity for glucose of plasma membrane glucose transporters. J Biol Chem. 1997;272:17276–17282
  15. Ahmed N, Berridge MV. Distinct regulation of glucose transport by interleukin-3 and oncogenes in a murine bone marrow-derived cell lines. Biochem Pharmacol. 1999;57:387–396
  16. Ogawa M. Differentiation and proliferation of hematopoietic cells. Blood. 1993;81:2844–2853
  17. Ghosal J, Chakraborty C, Biswas T, Ganguly CK, Datta AG. Effect of erythropoietin on the glucose transport of rat erythrocytes and bone marrow cells. Biochem Med Metab Biol. 1987;38:134–141
  18. Billat C, Jacquot R. Glucose uptake by rat erythroid cells: the effects of erythropoietin and dexamethasone. Exp Hematol. 1992;20:925–929
  19. Kim HD, Koury MJ, Lee SJ, Im JH, Sawyer ST. Metabolic adaptation during erythropoietin-mediated terminal differentiation of mouse erythroid cells. Blood. 1991;77:387–392
  20. Plantade A, Montravers F, Selle F, Izrael V, Talbot JN. Diffusely increased F-18 FDG uptake in bone marrow in a patient with acute anemia and recent erythropoietin therapy. Clin Nucl Med. 2003;28:771–772
  21. Blodgett TM, Ames JT, Torok FS, McCook BM, Meltzer CC. Diffuse bone marrow uptake on whole-body F-18 fluorodeoxyglucose positron emission tomography in a patient taking recombinant erythropoietin. Clin Nucl Med. 2004;29:161–163

PII: S0969-8051(06)00191-0

doi: 10.1016/j.nucmedbio.2006.09.005

Nuclear Medicine and Biology
Volume 33, Issue 8 , Pages 999-1004 , November 2006

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