Nuclear Medicine and Biology
Volume 33, Issue 8 , Pages 985-989 , November 2006

Evaluation of [14C]phenylacetate as a prototype tracer for the measurement of glial metabolism in the rat brain

  • Osamu Inoue

      Affiliations

    • Biomedical Physics and Engineering Laboratory, Course of Allied Health Sciences, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 6 6879 2563; fax: +81 6 6879 2563.
    • ,
  • Rie Hosoi

      Affiliations

    • Biomedical Physics and Engineering Laboratory, Course of Allied Health Sciences, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
    • ,
  • Sotaro Momosaki

      Affiliations

    • Biomedical Physics and Engineering Laboratory, Course of Allied Health Sciences, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
    • ,
  • Keisuke Yamamoto

      Affiliations

    • Biomedical Physics and Engineering Laboratory, Course of Allied Health Sciences, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
    • ,
  • Misato Amitani

      Affiliations

    • Biomedical Physics and Engineering Laboratory, Course of Allied Health Sciences, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
    • ,
  • Masatoshi Yamaguchi

      Affiliations

    • Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan
    • ,
  • Antony Gee

      Affiliations

    • Clinical Research Unit, GlaxoSmithKline, ACCI, Addenbrookes Hospital, Cambridge, UK

Received 1 August 2006 ,Revised 21 August 2006 ,Accepted 29 August 2006.

References 

  1. Muir D, Berl S, Clarke DD. Acetate and fluoroacetate as possible markers for glial metabolism in vivo. Brain Res. 1986;380(2):336–340
  2. Waniewski RA, Martin DL. Preferential utilization of acetate by astrocytes is attributable to transport. J Neurosci. 1998;18(14):5225–5233
  3. Hosoi R, Okada M, Hatazawa J, Gee A, Inoue O. Effect of astrocytic energy metabolism depressant on 14C–acetate uptake in intact rat brain. J Cereb Blood Flow Metab. 2004;24(2):188–190
  4. McCracken NW, Blain PG, Williams FM. Human xenobiotic metabolizing esterases in liver and blood. Biochem Pharmacol. 1993;46(7):1125–1129
  5. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 4th ed.. San Diego: Academic Press; 1998;
  6. Rigo P, de Landsheere C, Melon P, Kulbertus H. Imaging of myocardial metabolism by positron emission tomography. Cardiovasc Drugs Ther. 1990;(Suppl 4):847–851
  7. Shields AF, Graham MM, Kozawa SM, Kozell LB, Link JM, Swenson ER, et al. Contribution of labeled carbon dioxide to PET imaging of carbon-11-labeled compounds. J Nucl Med. 1992;33(4):581–584
  8. Mori M, Hosokawa M, Ogasawara Y, Tsukada E, Chiba K. cDNA cloning, characterization and stable expression of novel human brain carboxylesterase. FEBS Lett. 1999;458(1):17–22
  9. Gusson F, Carletti M, Albo AG, Dacasto M, Nebbia C. Comparison of hydrolytic and conjugative biotransformation pathways in horse, cattle, pig, broiler chick, rabbit and rat liver subcellullar fractions. Vet Res Commun. 2006;30(3):271–283
  10. Oakeshott JG, Claudianos C, Russell RJ, Robin GC. Carboxyl/cholinesterases: a case study of the evolution of a successful multigene family. Bioessays. 1999;21(12):1031–1042
  11. Huang TL, Szekacs A, Uematsu T, Kuwano E, Parkinson A, Hammock BD. Hydrolysis of carbonates, thiocarbonates, carbamates, and carboxylic esters of alpha-naphthol, beta-naphthol, and p-nitrophenol by human, rat, and mouse liver carboxylesterases. Pharm Res. 1993;10(5):639–648
  12. Satoh T, Hosokawa M. The mammalian carboxylesterases: from molecules to functions. Annu Rev Pharmacol Toxicol. 1998;38:257–288

PII: S0969-8051(06)00162-4

doi: 10.1016/j.nucmedbio.2006.08.007

Nuclear Medicine and Biology
Volume 33, Issue 8 , Pages 985-989 , November 2006

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