Nuclear Medicine and Biology
Volume 33, Issue 5 , Pages 645-651 , July 2006

In whole blood, LPS, TNF-alpha and GM-CSF increase monocyte uptake of 99mtechnetium stannous colloid but do not affect neutrophil uptake

  • Stuart C. Ramsay

      Affiliations

    • Townsville Nuclear Medicine, Mater Hospital, Pimlico, Queensland 4812, Australia
    • School of Medicine, James Cook University, Townsville, Queensland 4811, Australia
    • Corresponding Author InformationCorresponding author. Townsville Nuclear Medicine, Mater Hospital, Pimlico, QLD, Australia. Tel.: +61 7 47592800.
    • ,
  • Jacqueline Maggs

      Affiliations

    • Department of Nuclear Medicine, The Townsville Hospital, Townsville, Queensland 4814, Australia
    • ,
  • Kellie Powell

      Affiliations

    • School of Veterinary and Biomedical Sciences, James Cook University, Townsville, Queensland 4811, Australia
    • School of Medicine, James Cook University, Townsville, Queensland 4811, Australia
    • ,
  • Jodie Barnes

      Affiliations

    • School of Veterinary and Biomedical Sciences, James Cook University, Townsville, Queensland 4811, Australia
    • ,
  • Natkunam Ketheesan

      Affiliations

    • School of Veterinary and Biomedical Sciences, James Cook University, Townsville, Queensland 4811, Australia
    • School of Medicine, James Cook University, Townsville, Queensland 4811, Australia

Received 14 March 2006 ,Revised 4 April 2006 ,Accepted 15 April 2006.

References 

  1. Southee A, Lee K, McLaughlin A, et al. 99mTc White cell scintigraphy in suspected acute infection. Clin Nucl Med. 1990;15:71–75
  2. Chik K, Magee M, Bruce W, et al. 99mTc stannous colloid-labeled leukocyte scintigraphy in the evaluation of the painful arthroplasty. Clin Nucl Med. 1996;21:838–843
  3. Ramsay S, LaBrooy J, Norton R, Webb B. Demonstration of different patterns of musculoskeletal, soft tissue and visceral involvement in melioidosis using 99mTc stannous colloid white cell scanning. Nucl Med Comm. 2001;22:1193–1199
  4. Pullman W, Hanna R, Sullivan P, et al. Technetium-99m autologous phagocyte scanning: a new imaging technique for inflammatory bowel disease. Br Med J (Clin Res Ed). 1986;293:171–174
  5. Grimm MC, Pullman WE, Bennett GM. Direct evidence of monocyte recruitment to inflammatory bowel disease mucosa.. J Gastroenterol Hepatol. 1995;10:387–395
  6. Hanna R, Braun T, Levendel A, Lomas F. Radiochemistry and biostability of autologous leucocytes labelled with 99mTc-stannous colloid in whole blood. Eur J Nucl Med. 1984;9:216–219
  7. Hanna R, Lomas F. Identification of factors affecting technetium 99m leucocyte labelling by phagocytic engulfment and development of an optimal technique. Eur J Nucl Med. 1986;12:159–162
  8. McClelland CM, Onuegbulem E, Carter NJ, et al. 99mTc-SnF2 colloid ‘LLK’: particle size, morphology and leucocyte labelling behaviour. Nucl Med Commun. 2003;24:191–202
  9. Puncher MRB, Blower PJ. Labelling of leucocytes with colloidal technetium-99m-SnF2: an investigation of the labelling process by autoradiography. Eur J Nucl Med. 1995;22:101–107
  10. Gallagher H, Ramsay SC, Barnes J, Maggs J, Cassidy N, Ketheesan N. Neutrophil labeling with [99mTc]-technetium stannous colloid is complement receptor 3 mediated and increases the neutrophil priming response to lipopolysaccharide. Nucl Med Biol. 2006;33:433–439
  11. Ramsay SC, Maggs J, Ketheesan N, Norton R, LaBrooy J. Relative uptake of Technetium 99m stannous colloid by neutrophils and monocytes is altered by gram negative infection. Nucl Med Biol. 2005;32:101–107
  12. Miller SI, Ernst RK, Bader MW. LPS, TLR4 and infectious disease diversity. Nat Rev Microbiol. 2005;3:36–46
  13. Hackett SJ, Thomson AP, Hart CA. Cytokines, chemokines and other effector molecules involved in meningococcal disease. J Med Microbiol. 2001;50(10):847–859
  14. Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol. 2003;3:521–533
  15. Simpson A, Smith M, Weverling G. Prognostic value of cytokine concentrations and clinical parameters in severe melioidosis. J Infect Dis. 2000;181:621–625
  16. Beutler B. Science review: key inflammatory and stress pathways in clinical illness — the central role of the Toll-like receptors. Crit Care. 2003;7:39–46
  17. Amati L, Caradonna L, Leandro G, Magrone LG, Minenna M, Falco G, et al. Immune abnormalities and endotoxaemia in patients with ulcerative colitis and in their first degree relatives: attempts at neutralizing endotoxin-mediated effects. Curr Pharm Des. 2003;9:1937–1945
  18. Hubel K, Dale DC, Liles WC. Therapeutic use of cytokines to modulate phagocytic function for the treatment of infectious diseases: current status of G-CSF, GM-CSF, M-CSF and IFN-gamma. J Infect Dis. 2002;185:1490–1501
  19. Triantafilou M, Triantafilou K. The dynamics of LPS recognition: complex orchestration of multiple receptors. J Endotoxin Res. 2005;11:5–11
  20. Burrell R. Human responses to bacterial endotoxin. Circ Shock. 1994;43:137–153
  21. Wagner J, Roth R. Neutrophil migration during endotoxaemia. J Leukoc Biol. 1999;66:10–24
  22. Livingstone DH, Appel SH, Sonnenfeld G, Malangoni MA. The effect of tumour necrosis factor-alpha and interferon-gamma on neutrophil function. J Surg Res. 1989;46:322–326
  23. Juffermans NP, Dekkers PEP, Verbon A, Speelman P, Deventer SJH, Tom van der Poll T. Concurrent upregulation of urokinase plasminogen activator receptor and CD11b during tuberculosis and experimental endotoxemia. Infect Immun. 2001;69:5182–5185
  24. Furebring M, Hakansson L, Venge P, Sjolin J. Differential expression of the C5a receptor and complement receptors 1 and 3 after LPS stimulation of neutrophils and monocytes. Scand J Immunol. 2004;60:494–499
  25. Repo H, Jansson S-E, Leirisalo-Repo M. Anticoagulant selection influences flow cytometric determination of CD11b upregulation in vivo and ex vivo. J Immunol Methods. 1995;185:65–79
  26. Doherty DE, Downey GP, Schwab B, Elson E, Worthen GS. Lipolysaccharide-induced monocyte retention in the lung. Role of monocyte stiffness, actin assembly, and CD18-dependent adherence. J Immunol. 1994;153(1):241–255
  27. VanLeeuwen HJ, Van Dr Tol M, Van Strijp JA, Verhoef J, Van Kessel KP. The role of tumour necrosis factor in the kinetics of lipopolysaccharide-mediated neutrophil priming in whole blood. Clin Exp Immunol. 2005;140:65–72
  28. In:  Oppenheim JJ,  Feldmann M editor. Cytokine reference: a compendium of cytokines and other mediators of host defense. San Diego: Academic Press; 2001;
  29. In:  Thomson AW,  Lotze MT editor. The cytokine handbook. 4th ed.. Amsterdam: Academic press; 2003;
  30. Limb GA, Hamblin AS, Wolstencroft RA, Dumonde DC. Rapid cytokine up-regulation of integrins, complement receptor 1 and HLA-DR on monocytes but not on lymphocytes. Immunology. 1992;77(1):88–94
  31. Condliffe AM, Chilvers ER, Haslett C, Dransfield I. Priming differentially regulates neutrophil adhesion molecule expression/function. Immunology. 1996;89:105–111
  32. Brunelli R, Frasca D, Perrone G, Pioli C, Fattorossi A, Zichella L, et al. Hormone replacement therapy affects various immune cell subsets and natural cytotoxicity. Gynecol Obstet Invest. 1996;41(2):128–131
  33. Hamilton JA, Anderson GP. GM-CSF biology. Growth Factors. 2004;22:225–231
  34. Griffin JD, Spertini O, Ernst TJ, Belvin MP, Levine HB, Kanakura Y, et al. Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors. J Immunol. 1990;145(2):576–584
  35. Lundahl J, Hallden G, Hallgren M, Skold C, Hed J. Altered expression of CD11b/CD18 and CD62L on human monocytes after cell preparation procedures. J Immunol Methods. 1995;180:93–100
  36. Roilides E, Walsh TJ, Pizzo PA, Rubin M. Granulocyte colony-stimulating factor enhances the phagocytic and bactericidal activity of normal and defective human neutrophils. J Infect Dis. 1991;163:579–583
  37. Buckle AM, Hogg N. The effect of IFN-gamma and colony-stimulating factors on the expression of neutrophil cell membrane receptors. J Immunol. 1989;143:2295–2301
  38. Petroni KC, Shen L, Guyre PM. Modulation of human polymorphonuclear leukocyte IgG Fc receptors and Fc receptor-mediated functions by IFN-gamma and glucocorticoids. J Immunol. 1988;140:3467–3472

PII: S0969-8051(06)00068-0

doi: 10.1016/j.nucmedbio.2006.04.002

Nuclear Medicine and Biology
Volume 33, Issue 5 , Pages 645-651 , July 2006

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