Nuclear Medicine and Biology
Volume 33, Issue 4 , Pages 535-541 , May 2006

Acute treatment with pentobarbital alters the kinetics of in vivo receptor binding in the mouse brain

  • Yojiro Sakiyama

      Affiliations

    • Division of Clinical Research, National Institute of Radiological Sciences, Inage-ku, Chibashi 263-8555, Japan
    • Corresponding Author InformationCorresponding author. Research Planning and Coordination, Nagoya Laboratories, Pfizer Japan, Inc., Taketoyo, Aichi 470-2393, Japan. Tel.: +81 569 74 4653; fax: +81 569 74 4678.
  • ,
  • Masao Saito

      Affiliations

    • Department of Medical Science, Institute of Medical Electronics, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
  • ,
  • Osamu Inoue

      Affiliations

    • Department of Medical Physics, School of Allied Health Science, Faculty of Medicine, Osaka University, Suita, Osaka 565-0871, Japan

Received 14 October 2005 ,Revised 3 February 2006 ,Accepted 8 February 2006.

References 

  1. Honore T, Nielsen M, Braestrup C. Barbiturate shift as a tool for determination of efficacy of benzodiazepine–receptor ligands. Eur J Pharmacol. 1984;100:103–107
  2. Miller LG, Deutsch SI, Greenblatt DJ, Paul SM, Shader RI. Acute barbiturate administration increases benzodiazepine receptor binding in vivo. Psychopharmacology. 1988;96:385–390
  3. Miller LG, Greenblatt DJ, Barnhill JG, Summer WR, Shader RI. GABA shift in vivo: enhancement of benzodiazepine binding in vivo by modulation of endogenous GABA. Eur J Pharmacol. 1988;148:123–130
  4. Hashimoto K, Inoue O, Goromaru T, Yamasaki T. Changes in in vivo binding of [3H]Ro15-1788 in mouse brain by reserpine. Int J Rad Appl Instrum B. 1988;15:637–644
  5. Weizman R, Weizman A, Kook KA, Vocci F, Deutsch SI, Paul SM. Repeated swim stress alters brain benzodiazepine receptors measured in vivo. J Pharmacol Exp Ther. 1989;249:701–707
  6. Insel TR. Decreased in vivo binding to brain benzodiazepine receptors during social isolation. Psychopharmacology. 1989;97:142–144
  7. Abe K, Kashiwagi Y, Tokumura M, Hosoi R, Hatazawa J, Inoue O. Discrepancy between cell injury and benzodiazepine receptor binding after transient middle cerebral artery occlusion in rats. Synapse. 2004;53:234–239
  8. Lopez F, Miller LG, Thompson ML, Schatzki A, Chesley S, Greenblatt DJ, et al. Chronic morphine administration augments benzodiazepine binding and GABAA receptor function. Psychopharmacology. 1990;101:545–549
  9. Mintun MA, Raichle ME, Kilbourn MR, Wooten GF, Welch MJ. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol. 1984;15:217–227
  10. Marcus R, Peritz E, Gabriel KR. On closed testing procedure with special reference to ordered analysis of variance. Biometrika. 1976;63:655–660
  11. Rudolph U, Crestani F, Benke D, Brünig I, Benson JA, Fritschy JM, et al. Benzodiazepine actions mediated by specific γ-aminobutyric acid A receptor subtypes. Nature. 1999;401:796–800
  12. Korpi ES, Gründer G, Lüddens H. Drug interactions at GABAA receptors. Prog Neurobiol. 2002;67:113–159
  13. Berezhnoy D, Nyfeler Y, Gonthier A, Schwob H, Goeldner M, Sigel E. On the benzodiazepine binding pocket in GABAA receptors. J Biol Chem. 2004;279:3160–3168
  14. Berezhnoy D, Baur R, Gonthier A, Foucaud B, Goeldner M, Sigel E. Conformational changes at benzodiazepine binding sites of GABAA receptors detected with a novel technique. J Neurochem. 2005;92:859–866
  15. Inoue O, Kobayashi K, Sakiyama Y, Suzuki T. The effect of benzodiazepines on the binding of [3H]SCH 23390 in vivo. Neuropharmacology. 1992;31:115–121
  16. Kobayashi K, Inoue O. An increase in the in vivo binding of [3H]SCH 23390 induced by MK-801 in the mouse striatum. Neuropharmacology. 1993;32:341–348
  17. Harris RA, Schroeder F. Effects of barbiturates and ethanol on the physical properties of brain membranes. J Pharmacol Exp Ther. 1982;223:424–431
  18. Inoue O, Kobayashi K, Suhara T. Effect of sedative drugs upon receptor binding in vivo. Prog Neuro-Psychopharmacol Biol Psychiatry. 1992;16:783–789
  19. Delforge J, Syrota A, Bendriem B. Concept of reaction volume in the in vivo ligand–receptor model. J Nucl Med. 1996;37:118–125
  20. Inoue O, Kobayashi K, Gee A. Changes in apparent rates of receptor binding in the intact brain in relation to the heterogeneity of reaction environments. Crit Rev Neurobiol. 1999;13:199–225
  21. Albrecht RF, Cook J, Hoffman WE, Larscheid P, Miletich DJ, Naughton N. The interaction between benzodiazepine antagonists and barbiturate-induced cerebrovascular and cerebral metabolic depression. Neuropharmacology. 1985;24:957–963
  22. Otsuka T, Wei L, Acuff VR, Shimizu A, Pettigrew KD, Patlak CS, et al. Variation in local cerebral blood flow response to high-dose pentobarbital sodium in the rat. Am J Physiol. 1991;261:H110–H120
  23. Hosoi R, Kobayashi K, Watanabe Y, Inoue O. Discrepancy of benzodiazepine receptor occupancy between [3H]flumazenil and [125I]iomazenil in intact mouse brain. J Neural Transm. 1999;106:243–256
  24. Inoue O, Hosoi R, Kobayashi K, Itoh T, Gee A, Suzuki K. Different sensitivities to competitive inhibition of benzodiazepine receptor binding of [11C]iomazenil and [11C]flumazenil in rhesus monkey brain. Ann Nucl Med. 2001;15:137–139
  25. Shinotoh H, Yamasaki T, Inoue O, Itoh T, Suzuki T, Hashimoto K, et al. Visualization of specific binding sites of benzodiazepine in human brain. J Nucl Med. 1986;27:1593–1599
  26. Persson A, Ehrin E, Eriksson L, Farde L, Hedstrom C, Litton J-E, et al. Imaging of [11C]-labelled Ro15-1788 binding to benzodiazepine receptors in the human brain by positron emission tomography. J Psychiat Res. 1985;19:609–622
  27. Samson Y, Hantraye P, Baron JC, Soussaline F, Comar D, Maziere M. Kinetics and displacement of [11C]Ro15-1788, a benzodiazepine antagonist, studied in human brain in vivo by positron tomography. Eur J Pharmacol. 1985;110:247–251
  28. Padma MV, Simkins R, White P, Satter M, Christian BT, Dunigan K, et al. Clinical utility of [11C]-flumazenil positron emission tomography in intractable temporal lobe epilepsy. Neurology (India). 2004;52:457–462
  29. Tsukamoto M, Katoh C, Shiga T, Kaji T, Kuge Y, Nakada K, et al. Use of a standardized uptake value for parametric in vivo imaging of benzodiazepine receptor distribution on [11C]-flumazenil brain PET. Eur J Nucl Med Mol Imaging. 2004;31:846–851
  30. Salmi E, Kaisti KK, Metsahonkala L, Oikonen V, Aalto S, Nagren K, et al. Sevoflurane and propofol increase [11C]-flumazenil binding to gamma-aminobutyric acid A receptors in humans. Anesth Analg. 2004;99:1420–1426

PII: S0969-8051(06)00019-9

doi: 10.1016/j.nucmedbio.2006.02.002

Nuclear Medicine and Biology
Volume 33, Issue 4 , Pages 535-541 , May 2006