Nuclear Medicine and Biology
Volume 33, Issue 4 , Pages 521-528 , May 2006

[11C]palmitate kinetics across the splanchnic bed in arterial, portal and hepatic venous plasma during fasting and euglycemic hyperinsulinemia

  • Letizia Guiducci

      Affiliations

    • SSSUP Medical Sciences Branch, Pisa 56100, Italy
    • Turku PET Centre, University of Turku, Turku 20520, Finland
    • PET Centre, Institute of Clinical Physiology, CNR National Research Council, 56100 Pisa, Italy
    • ,
  • Mikko Järvisalo

      Affiliations

    • Turku PET Centre, University of Turku, Turku 20520, Finland
    • ,
  • Jan Kiss

      Affiliations

    • Turku PET Centre, University of Turku, Turku 20520, Finland
    • Department of Surgery, University of Turku, Turku 20520, Finland
    • ,
  • Kjell Någren

      Affiliations

    • Turku PET Centre, University of Turku, Turku 20520, Finland
    • ,
  • Antti Viljanen

      Affiliations

    • Turku PET Centre, University of Turku, Turku 20520, Finland
    • ,
  • Alexandru G. Naum

      Affiliations

    • Turku PET Centre, University of Turku, Turku 20520, Finland
    • ,
  • Amalia Gastaldelli

      Affiliations

    • PET Centre, Institute of Clinical Physiology, CNR National Research Council, 56100 Pisa, Italy
    • ,
  • Timo Savunen

      Affiliations

    • Department of Surgery, University of Turku, Turku 20520, Finland
    • ,
  • Juhani Knuuti

      Affiliations

    • Turku PET Centre, University of Turku, Turku 20520, Finland
    • ,
  • Piero A. Salvadori

      Affiliations

    • PET Centre, Institute of Clinical Physiology, CNR National Research Council, 56100 Pisa, Italy
    • ,
  • Ele Ferrannini

      Affiliations

    • PET Centre, Institute of Clinical Physiology, CNR National Research Council, 56100 Pisa, Italy
    • Department of Internal Medicine, University of Pisa School of Medicine, Pisa 56100, Italy
    • ,
  • Pirjo Nuutila

      Affiliations

    • Turku PET Centre, University of Turku, Turku 20520, Finland
    • Department of Medicine, University of Turku, Turku 20520, Finland
    • ,
  • Patricia Iozzo

      Affiliations

    • Turku PET Centre, University of Turku, Turku 20520, Finland
    • PET Centre, Institute of Clinical Physiology, CNR National Research Council, 56100 Pisa, Italy
    • Corresponding Author InformationCorresponding author. Institute of Clinical Physiology, CNR National Research Council, 56100 Pisa, Italy.

Received 25 October 2005 ,Revised 10 January 2006 ,Accepted 1 February 2006.

References 

  1. Lewis GF, Carpentier A, Adeli K, Giacca A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev. 2002;23:201–229
  2. Lam TKT, Carpentier A, Lewis GF, Van de Werve G, Fantus IG. Mechanism of the free fatty acid-induced increase in hepatic glucose production. Am J Physiol Endocrinol Metab. 2003;284:E863–E873
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  15. Schon HR, Schelbert HR, Robinson G, Najafi A, Huang SC, Hansen H, et al. C-11 palmitate for the non-invasive evaluation of regional myocardial fatty acid metabolism with positron computed tomography: I. Kinetics of C-11 palmitic acid in normal myocardium. Am Heart J. 1982;103(4 (Pt 1)):532–547
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  18. Munk OL, Bass L, Roelsgaard K, Bender D, Hansen SB, Keiding S. Liver kinetics of glucose analogs measured in pigs by PET: importance of dual-input blood sampling. J Nucl Med. 2001;42:795–801

PII: S0969-8051(06)00017-5

doi: 10.1016/j.nucmedbio.2006.02.003

Nuclear Medicine and Biology
Volume 33, Issue 4 , Pages 521-528 , May 2006

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