Nuclear Medicine and Biology
Volume 33, Issue 3 , Pages 349-358 , April 2006

Dual optical and nuclear imaging in human melanoma xenografts using a single targeted imaging probe

  • Chun Li

      Affiliations

    • Department of Experimental Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 713 792 5182; fax: +1 713 794 5456.
  • ,
  • Wei Wang

      Affiliations

    • Department of Experimental Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
  • ,
  • Qingping Wu

      Affiliations

    • Department of Experimental Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
  • ,
  • Shi Ke

      Affiliations

    • Department of Experimental Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
  • ,
  • Jessica Houston

      Affiliations

    • Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA
  • ,
  • Eva Sevick-Muraca

      Affiliations

    • Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA
  • ,
  • Liang Dong

      Affiliations

    • Department of Pharmaceutical Sciences, Texas Southern University, Houston, TX 77030, USA
  • ,
  • Diana Chow

      Affiliations

    • Department of Pharmacology and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77030, USA
  • ,
  • Chusilp Charnsangavej

      Affiliations

    • Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
  • ,
  • Juri G. Gelovani

      Affiliations

    • Department of Experimental Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA

Received 10 December 2005 ,Revised 2 January 2006 ,Accepted 3 January 2006.

References 

  1. Weissleder R, Mahmood U. Molecular imaging. Radiology. 2001;219:316–333
  2. Sokolov K, Follen M, Aaron J, et al. Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles. Cancer Res. 2003;63:1999–2004
  3. Ntziachristos V, Bremer C, Weissleder R. Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging. Eur Radiol. 2003;13:195–208
  4. Gurfinkel M, Ke S, Wen X, Li C, Sevick-Muraca EM. Near-infrared fluorescence optical imaging and tomography. Dis Markers. 2003;19:107–121
  5. Ke S, Wen X, Gurfinkel M, et al. Near-infrared optical imaging of epidermal growth factor receptor in breast cancer xenografts. Cancer Res. 2003;63:7870–7875
  6. Felding-Habermann B, Mueller BM, Romerdahl CA, Cheresh DA. Involvement of integrin alpha V gene expression in human melanoma tumorigenicity. J Clin Invest. 1992;89:2018–2022
  7. Brooks PC, Clark RA, Cheresh DA. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science. 1994;264:569–571
  8. Schuchter L, Schultz DJ, Synnestvedt M, et al. A prognostic model for predicting 10-year survival in patients with primary melanoma. The Pigmented Lesion Group. Ann Intern Med. 1996;125:369–375
  9. Hieken TJ, Farolan M, Ronan SG, et al. Beta3 integrin expression in melanoma predicts subsequent metastasis. J Surg Res. 1996;63:169–173
  10. Chen X, Conti PS, Moats RA. In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in brain tumor xenografts. Cancer Res. 2004;64:8009–8014
  11. Wang W, Ke S, Wu Q, et al. Near-infrared optical imaging of integrin alphavbeta3 in human tumor xenografts. Mol Imaging. 2004;3:343–351
  12. Haubner R, Wester HJ, Reuning U, et al. Radiolabeled alpha(v)beta3 integrin antagonists: a new class of tracers for tumor targeting. J Nucl Med. 1999;40:1061–1071
  13. Haubner R, Wester HJ, Weber WA, et al. Noninvasive imaging of alpha(v)beta3 integrin expression using 18F-labeled RGD-containing glycopeptide and positron emission tomography. Cancer Res. 2001;61:1781–1785
  14. Brechbiel MW, Gansow OA, Atcher RW, Schlom J, Esteban J, Simpson DE, et al. Synthesis of 1-(p-isothiocyanatobenzyl) derivatives of DTPA and EDTA. Antibody labeling and tumor-imaging studies. Inorg Chem. 1986;25:2772–2781
  15. Houston JP, Ke S, Wang W, Li C, Sevick-Muraca EM. Quality analysis of in vivo near-infrared fluorescence and conventional gamma images acquired using a dual-labeled tumor-targeting probe. J Biomed Opt. 2005;10:54010
  16. Janssen ML, Oyen WJ, Dijkgraaf I, et al. Tumor targeting with radiolabeled alpha(v)beta(3) integrin binding peptides in a nude mouse model. Cancer Res. 2002;62:6146–6151
  17. Haubner R, Bruchertseifer F, Bock M, et al. Synthesis and biological evaluation of a (99m)Tc-labelled cyclic RGD peptide for imaging the alphavbeta3 expression. Nuklearmedizin. 2004;43:26–32
  18. Rajagopalan R, Uetrecht P, Bugaj JE, Achilefu SA, Dorshow RB. Stabilization of the optical tracer agent indocyanine green using noncovalent interactions. Photochem Photobiol. 2000;71:347–350
  19. Becker A, Hessenius C, Licha K, et al. Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands. Nat Biotechnol. 2001;19:327–331
  20. Achilefu S, Dorshow RB, Bugaj JE, Rajagopalan R. Novel receptor-targeted fluorescent contrast agents for in vivo tumor imaging. Invest Radiol. 2000;35:479–485
  21. Bugaj JE, Achilefu S, Dorshow RB, Rajagopalan R. Novel fluorescent contrast agents for optical imaging of in vivo tumors based on a receptor-targeted dye-peptide conjugate platform. J Biomed Opt. 2001;6:122–133
  22. Zaheer A, Lenkinski RE, Mahmood A, et al. In vivo near-infrared fluorescence imaging of osteoblastic activity. Nat Biotechnol. 2001;19:1148–1154
  23. Godavarty A, Thompson AB, Roy R, et al. Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography. J Biomed Opt. 2004;9:488–496
  24. Ntziachristos V, Schellenberger EA, Ripoll J, et al. Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate. Proc Natl Acad Sci U S A. 2004;101:12294–12299

PII: S0969-8051(06)00004-7

doi: 10.1016/j.nucmedbio.2006.01.001

Nuclear Medicine and Biology
Volume 33, Issue 3 , Pages 349-358 , April 2006