Nuclear Medicine and Biology
Volume 33, Issue 3 , Pages 367-370, April 2006

Synthesis of 5-radioiodoarabinosyl uridine analog for probing HSV-1 thymidine kinase gene: an unexpected chelating effect

Department of Nuclear Science, National Tsing-Hua University, Hsinchu 300, Taiwan

Received 2 June 2005; received in revised form 8 December 2005; accepted 8 December 2005. published online 13 March 2006.

Abstract 

Tumor cells transduced with herpes simplex virus thymidine kinase gene has been intensively applied to the field of positron emission tomography via imaging of its substrate. As a pilot synthesis approach, a facial preparation of 5-[125I]iodoarabinosyl uridine starting from commercial available uridine is reported herein. Interestingly, the tin group in 5-trimethylstannyl arabinosyluridine was easily removed during purification. The destannylation through the formation of a six-ligand coordination involving 2′-hydroxyl and tin was thereby proposed.

Keywords: Arabinosyl, Chelating, HSV-1 TK, PET, Tin, Uridine

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PII: S0969-8051(05)00300-8

doi:10.1016/j.nucmedbio.2005.12.005

Nuclear Medicine and Biology
Volume 33, Issue 3 , Pages 367-370, April 2006

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