Nuclear Medicine and Biology
Volume 33, Issue 2 , Pages 239-243 , February 2006

Ketamine displaces the novel NMDA receptor SPET probe [123I]CNS-1261 in humans in vivo

  • James M. Stone

      Affiliations

    • Institute of Psychiatry, King's College London, De Crespigny Park London, SE5 8AF UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 020 7848 0531.
    • ,
  • Kjell Erlandsson

      Affiliations

    • Institute of Nuclear Medicine, University College London, London, W1N 8AA UK
    • ,
  • Erik Årstad

      Affiliations

    • Institute of Psychiatry, King's College London, De Crespigny Park London, SE5 8AF UK
    • ,
  • Rodrigo A. Bressan

      Affiliations

    • Institute of Psychiatry, King's College London, De Crespigny Park London, SE5 8AF UK
    • ,
  • Lisa Squassante

      Affiliations

    • GlaxoSmithKline (GSK), Verona 37135, Italy
    • ,
  • Vincenza Teneggi

      Affiliations

    • GlaxoSmithKline (GSK), Verona 37135, Italy
    • ,
  • Peter J. Ell

      Affiliations

    • Institute of Nuclear Medicine, University College London, London, W1N 8AA UK
    • ,
  • Lyn S. Pilowsky

      Affiliations

    • Institute of Psychiatry, King's College London, De Crespigny Park London, SE5 8AF UK
    • Institute of Nuclear Medicine, University College London, London, W1N 8AA UK

Received 3 October 2005 ,Revised 2 December 2005 ,Accepted 4 December 2005.

References 

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  6. Owens J, Tebbutt AA, McGregor AL, Kodama K, Magar SS, Perlman ME, et al. Synthesis and binding characteristics of N-(1-naphthyl)-N′-(3-[125I]-iodophenyl)-N′-methylguanidine ([125I]-CNS-1261): a potential SPECT agent for imaging NMDA receptor activation. Nucl Med Biol. 2000;27:557–564
  7. Erlandsson K, Bressan RA, Mulligan RS, Gunn RN, Cunningham VJ, Owens J, et al. Kinetic modelling of [123I]-CNS-1261 — a novel SPET tracer for the NMDA receptor. Nucl Med Biol. 2003;30:441–454
  8. Bressan RA, Erlandsson K, Mulligan RS, Gunn RN, Cunningham VJ, Owen J, et al. Development of a bolus/infusion paradigm for the novel NMDA receptor tracer [123I]CNS-1261: comparison with bolus studies. Nucl Med Biol. 2004;31:155–164
  9. Overall JE, Gorham DR. The Brief Psychiatric Rating Scale. Psychol Rep. 1962;10:799–812
  10. Friston KJ, Ashburner J, Poline JB, Frith CD, Heather JD, Frackowiak RSJ. Spatial registration and normalisation of images. Hum Brain Mapp. 1995;2:165–189
  11. Takeuchi R, Yonekura Y, Matsuda H, Konishi J. Usefulness of a three-dimensional stereotaxic ROI template on anatomically standardised 99mTc-ECD SPET. Eur J Nucl Med Mol Imaging. 2002;29:331–341
  12. Carson RE. PET physiological measurements using constant infusion. Nucl Med Biol. 2000;27:657–660[Review]
  13. Holcomb HH, Lahti AC, Medoff DR, Weiler M, Tamminga CA. Sequential regional cerebral blood flow brain scans using PET with H2(15)O demonstrate ketamine actions in CNS dynamically. Neuropsychopharmacology. 2001;25(2):165–172

☆ There are no conflicts of interest to report. LSP, EA, and KE were supported by a UK Medical Research Council Senior Clinical Research Fellowship to LSP. JS and RAB were supported by a research grant from GSK.

PII: S0969-8051(05)00294-5

doi: 10.1016/j.nucmedbio.2005.12.001

Nuclear Medicine and Biology
Volume 33, Issue 2 , Pages 239-243 , February 2006

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