Nuclear Medicine and Biology
Volume 33, Issue 2 , Pages 245-248 , February 2006

Noninvasive monitoring of colonic carcinogenesis: feasibility of [18F]FDG-PET in the azoxymethane model

  • Mariëtte C.A. van Kouwen

      Affiliations

    • Department of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, 6500 HB Nijmegen, The Netherlands
    • ,
  • Peter Laverman

      Affiliations

    • Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31 24 3615054; fax: +31 24 3618942.
    • ,
  • J. Han J.M. van Krieken

      Affiliations

    • Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, 6500 HB Nijmegen, The Netherlands
    • ,
  • Wim J.G. Oyen

      Affiliations

    • Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    • ,
  • Fokko M. Nagengast

      Affiliations

    • Department of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, 6500 HB Nijmegen, The Netherlands
    • ,
  • Joost P.H. Drenth

      Affiliations

    • Department of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, 6500 HB Nijmegen, The Netherlands

Received 30 September 2005 ,Revised 27 October 2005 ,Accepted 23 November 2005.

References 

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  2. Troisi RJ, Freedman AN, Devesa SS. Incidence of colorectal carcinoma in the US — An update of trends by gender, race, age, subsite, and stage, 1975–1994. Cancer. 1999;85:1670–1676
  3. Reddy BS. Studies with the azoxymethane-rat preclinical model for assessing colon tumor development and chemoprevention. Environ Mol Mutagen. 2004;44:26–35
  4. Delbeke D. Oncological applications of FDG PET imaging: brain tumors, colorectal cancer lymphoma and melanoma. J Nucl Med. 1999;40:591–603
  5. Ward JM. Dose response to a single injection of azoxymethane in rats. Induction of tumors in the gastrointestinal tract, auditory sebaceous glands, kidney, liver and preputial gland. Vet Pathol. 1975;12:165–177
  6. Corpet DE, Pierre F. Point: from animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. Cancer Epidemiol Biomarkers Prev. 2003;12:391–400
  7. Macejova D, Brtko J. Chemically induced carcinogenesis: a comparison of 1-methyl-1-nitrosourea, 7,12-dimethylbenzanthracene,diethylnitroso-amine and azoxymethan models (minireview). Endocr Regul. 2001;35:53–59
  8. Schlemper RJ, Riddell PH, Kato Y, Borchard F, Cooper HS, Dawsey SM, et al. The Vienna classification of gastrointestinal epithelial neoplasia. Gut. 2000;47:251–255
  9. Yasuda S, Fujii H, Nakahara T, Nishiumi N, Takahashi W, Ide M, et al. F-18-FDG PET detection of colonic adenomas. J Nucl Med. 2001;42:989–992
  10. van Kouwen MC, Nagengast FM, Jansen JB, Oyen WJ, Drenth JP. 2-(18F)-Fluoro-2-deoxy-d-glucose positron emission tomography detects clinical relevant adenomas of the colon: a prospective study. J Clin Oncol. 2005;23:3713–3717

PII: S0969-8051(05)00277-5

doi: 10.1016/j.nucmedbio.2005.11.003

Nuclear Medicine and Biology
Volume 33, Issue 2 , Pages 245-248 , February 2006

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